7OEL

Crystal structure of the human METTL3-METTL14 complex with compound UOZ097

Summary for 7OEL

• Entry DOI: 10.2210/pdb7oel/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ~{N}-[[(3~{R})-1-[6-(3~{H}-benzimidazol-4-ylmethylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-4-[(4,4-dimethylpiperidin-1-yl)methyl]benzamide, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 62407.11

Authors

Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2021-05-03, release date: 2021-10-20, Last modification date: 2024-02-07)

• Primary citation: Bedi, R.K.,Huang, D.,Li, Y.,Caflisch, A.; Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3; Acs Bio Med Chem Au, 2023; DOI: 10.1021/acsbiomedchemau.3c00023

Experimental method

X-RAY DIFFRACTION (1.86 Å)