7O08

Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ADO_AB_075)

Summary for 7O08

• Entry DOI: 10.2210/pdb7o08/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-4-ol, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 62340.06

Authors

Bedi, R.K.,Dolbois, A.,Caflisch, A. (deposition date: 2021-03-25, release date: 2021-09-01, Last modification date: 2024-01-31)

• Primary citation: Dolbois, A.,Bedi, R.K.,Bochenkova, E.,Muller, A.,Moroz-Omori, E.V.,Huang, D.,Caflisch, A.; 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.; J.Med.Chem., 64:12738-12760, 2021; PubMed: 34431664; DOI: 10.1021/acs.jmedchem.1c00773

Experimental method

X-RAY DIFFRACTION (2 Å)