7O08

Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ADO_AB_075)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001510	biological_process	RNA methylation
A	0001734	molecular_function	mRNA m(6)A methyltransferase activity
A	0005634	cellular_component	nucleus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interaction with METTL3 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2

Chain	Residue	Details
B	TYR146
B	ASP242
B	ARG245
B	ARG298

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2, ECO:0007744|PDB:5K7U, ECO:0007744|PDB:5K7W

Chain	Residue	Details
A	ASP395
A	LYS513

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Interaction with METTL14 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2

Chain	Residue	Details
A	GLU438
A	ARG441

---