6Y4G
Crystal structure of the human METTL3-METTL14 complex bound to Sinefungin
Summary for 6Y4G
| Entry DOI | 10.2210/pdb6y4g/pdb |
| Descriptor | N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, SINEFUNGIN, ... (5 entities in total) |
| Functional Keywords | inhibitor, complex, mettl3, sinefungin, mettl14, transferase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 117232.76 |
| Authors | Bedi, R.K.,Omori, E.,Caflisch, A. (deposition date: 2020-02-20, release date: 2020-03-04, Last modification date: 2024-01-24) |
| Primary citation | Bedi, R.K.,Huang, D.,Eberle, S.A.,Wiedmer, L.,Sledz, P.,Caflisch, A. Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. Chemmedchem, 15:744-748, 2020 Cited by PubMed: 32159918DOI: 10.1002/cmdc.202000011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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