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PDB: 126 件
8F3A
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BU of 8f3a by Molmil
HIV-1 gp41 coiled-coil pocket IQN17
分子名称: ACETIC ACID, CHLORIDE ION, IQN17
著者Bruun, T.U.J, Tang, S, Fernandez, D, Kim, P.S.
登録日2022-11-09
公開日2023-03-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies.
J.Biol.Chem., 299, 2023
6UCF
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BU of 6ucf by Molmil
N123-VRC34_pI4 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519
分子名称: HIV fusion peptide, N123-VRC34_pI4 heavy chain, N123-VRC34_pI4 light chain
著者Xu, K, Kwong, P.D.
登録日2019-09-16
公開日2020-03-18
最終更新日2020-04-22
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Cell Host Microbe, 27, 2020
6PSA
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BU of 6psa by Molmil
PIE12 D-PEPTIDE AGAINST HIV ENTRY (IN COMPLEX WITH IQN17 Q577R RESISTANCE MUTANT)
分子名称: CHLORIDE ION, IQN17, PIE12 D-peptide
著者Hill, C.P, Whitby, F.G, Kay, M, Weinstock, M.
登録日2019-07-12
公開日2020-02-05
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Characterization of resistance to a potent D-peptide HIV entry inhibitor.
Retrovirology, 16, 2019
6UCE
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BU of 6uce by Molmil
N123-VRC34_pI3 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519
分子名称: HIV fusion peptide, N123-VRC34_pI3 heavy chain, N123-VRC34_pI3 light chain
著者Xu, K, Kwong, P.D.
登録日2019-09-16
公開日2020-03-18
最終更新日2020-04-22
実験手法X-RAY DIFFRACTION (1.382 Å)
主引用文献VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Cell Host Microbe, 27, 2020
1DF4
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BU of 1df4 by Molmil
INTERACTIONS BETWEEN HIV-1 GP41 CORE AND DETERGENTS AND THEIR IMPLICATIONS FOR MEMBRANE FUSION
分子名称: HIV-1 ENVELOPE GLYCOPROTEIN GP41
著者Shu, W, Ji, H, Lu, M.
登録日1999-11-17
公開日1999-11-24
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Interactions between HIV-1 gp41 core and detergents and their implications for membrane fusion.
J.Biol.Chem., 275, 2000
7EKB
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BU of 7ekb by Molmil
Crystal structure of 4E10 modified with pyrene acetamide
分子名称: ACETATE ION, Fab region of the heavy chain of broadly neutralizing antibody anti-HIV-1 4E10, Fab region of the light chain of the broadly neutralizing anti-HIV-1 antibody 4E10, ...
著者Caaveiro, J.M.M, Rujas, E, Nieva, J.L.
登録日2021-04-05
公開日2021-08-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
Iscience, 24, 2021
6BXP
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BU of 6bxp by Molmil
Crystal Structure of HLA-B*57:01 with a modified HIV peptide RKV-Kyn
分子名称: ACETATE ION, Beta-2-microglobulin, HIV peptide RKV-Kyn, ...
著者Gras, S, Rossjohn, J.
登録日2017-12-18
公開日2018-03-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics.
Proteomics, 18, 2018
5X08
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BU of 5x08 by Molmil
Crystal structure of broadly neutralizing anti-HIV-1 antibody 4E10, mutant Npro, with peptide bound
分子名称: ACETATE ION, CHLORIDE ION, Envelope glycoprotein gp160, ...
著者Caaveiro, J.M.M, Rujas, E, Nieva, J.L, Tsumoto, K.
登録日2017-01-20
公開日2017-04-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Functional Contacts between MPER and the Anti-HIV-1 Broadly Neutralizing Antibody 4E10 Extend into the Core of the Membrane
J. Mol. Biol., 429, 2017
6JQK
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Structure of C34M/N36
分子名称: C34M, N36
著者Yu, D.W, Qin, B.
登録日2019-03-31
公開日2020-04-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.498 Å)
主引用文献Structure of C34M/N36
To Be Published
5TKK
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BU of 5tkk by Molmil
Structure of mouse vaccination-elicited HIV neutralizing antibody vFP5.01 in complex with HIV-1 fusion peptide residue 512-519
分子名称: HIV-1 fusion peptide residue 512-519, mouse antibody vFP5.01 heavy chain, mouse antibody vFP5.01 light chain
著者Xu, K, Liu, K, Kwong, P.D.
登録日2016-10-06
公開日2018-04-04
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6PDR
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BU of 6pdr by Molmil
Vaccine-elicited murine FP-targeting antibody vFP25.18 in complex with HIV fusion peptide (residue 512-519)
分子名称: HIV fusion peptide residue 512-519, antibody vFP25.18 heavy chain, antibody vFP25.18 light chain
著者Xu, K, Liu, K, Wang, Y, Kwong, P.D.
登録日2019-06-19
公開日2020-06-24
実験手法X-RAY DIFFRACTION (1.555 Å)
主引用文献Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6BXQ
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BU of 6bxq by Molmil
Crystal Structure of HLA-B*57:01 with an HIV peptide RKV
分子名称: Beta-2-microglobulin, HIV peptide RKV, MHC class I antigen
著者Gras, S, Rossjohn, J.
登録日2017-12-18
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics.
Proteomics, 18, 2018
6KTS
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BU of 6kts by Molmil
Structure of C34N126K/N36
分子名称: Envelope glycoprotein, Glycoprotein 41
著者Yu, D.W, Qin, B.
登録日2019-08-28
公開日2020-09-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and Functional Characterization of the Secondary Mutation N126K Selected by Various HIV-1 Fusion Inhibitors.
Viruses, 12, 2020
7FF1
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BU of 7ff1 by Molmil
Structure of C34E136G/N36
分子名称: gp41 C34E136G, gp41 N36
著者Yu, D.W, Qin, B.
登録日2021-07-22
公開日2022-11-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.689 Å)
主引用文献Structure of C34E136G/N36
To Be Published
5CIN
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BU of 5cin by Molmil
Crystal Structure of non-neutralizing version of 4E10 (DeltaLoop) with epitope bound
分子名称: CHLORIDE ION, FAB 4E10 HEAVY CHAIN, FAB 4E10 LIGHT CHAIN, ...
著者Caaveiro, J.M.M, Rujas, E, Nieva, J.L, Tsumoto, K.
登録日2015-07-13
公開日2015-09-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10
J.Virol., 89, 2015
7N05
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BU of 7n05 by Molmil
Crystal structure of the F240 antibody fragment bound to the HIV-1 gp41 immunodominant region
分子名称: ACETATE ION, Fab F240 heavy chain, Fab F240 light chain, ...
著者Cook, J.D, Lee, J.E.
登録日2021-05-25
公開日2022-03-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies.
Commun Biol, 5, 2022
7EKK
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BU of 7ekk by Molmil
Anti-HIV-1 broadly neutralizing antibody delta-loop 4E10 modified with pyrene acetamide
分子名称: AMMONIUM ION, CHLORIDE ION, GLYCEROL, ...
著者Caaveiro, J.M.M, Rujas, E, Nieva, J.L.
登録日2021-04-05
公開日2021-08-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
Iscience, 24, 2021
6RYF
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BU of 6ryf by Molmil
High-resolution crystal structure of ERAP1 in complex with 15mer phosphinic peptide
分子名称: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Giastas, P, Stratikos, E.
登録日2019-06-10
公開日2019-12-18
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1.
Proc.Natl.Acad.Sci.USA, 2019
6PEC
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BU of 6pec by Molmil
Vaccine-elicited NHP FP-targeting antibody DF2F-e.01 in complex with HIV fusion peptide (residue 512-519)
分子名称: HIV-1 fusion peptide residue 512-519, antibody heavy chain, antibody light chain
著者Xu, K, Liu, K, Wang, Y, Kwong, P.D.
登録日2019-06-20
公開日2020-06-24
実験手法X-RAY DIFFRACTION (1.746 Å)
主引用文献Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
1K33
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BU of 1k33 by Molmil
Crystal structure analysis of the gp41 core mutant
分子名称: Transmembrane glycoprotein GP41
著者Shu, W, Lu, M.
登録日2001-10-01
公開日2001-10-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Interhelical interactions in the gp41 core: implications for activation of HIV-1 membrane fusion.
Biochemistry, 41, 2002
6P7H
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BU of 6p7h by Molmil
Vaccine-elicited NHP FP-targeting neutralizing antibody DF2F-b.04 in complex with HIV fusion peptide (residue 512-519)
分子名称: Antibody DF2F-b.04 heavy chain, Antibody DF2F-b.04 light chain, HIV fusion peptide residues (512-519)
著者Xu, K, Liu, K, Wang, Y, Kwong, P.D.
登録日2019-06-05
公開日2020-06-10
実験手法X-RAY DIFFRACTION (1.782 Å)
主引用文献Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
5KA5
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BU of 5ka5 by Molmil
HIV-1 gp41 variant V549E resistance mutation
分子名称: Transmembrane glycoprotein gp41
著者Bhardwaj, A, Khasnis, M.D, Halkidis, K, Root, M.J.
登録日2016-06-01
公開日2016-12-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.
PLoS Pathog., 12, 2016
1GZL
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BU of 1gzl by Molmil
Crystal structure of C14linkmid/IQN17: a cross-linked inhibitor of HIV-1 entry bound to the gp41 hydrophobic pocket
分子名称: CHLORIDE ION, ENVELOPE GLYCOPROTEIN GP41, FUSION PROTEIN BETWEEN THE HYDROPHOBIC POCKET OF HIV GP41 AND GENERAL CONTROL PROTEIN GCN4-PIQI, ...
著者Sia, S.K, Carr, P.A, Cochran, A.G, Malashkevich, V.M, Kim, P.S.
登録日2002-05-23
公開日2002-10-10
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Short Constrained Peptides that Inhibit HIV-1 Entry
Proc.Natl.Acad.Sci.USA, 99, 2002
3MNZ
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BU of 3mnz by Molmil
Crystal structure of the non-neutralizing HIV antibody 13H11 Fab fragment with a gp41 MPER-derived peptide bearing Ala substitutions in a helical conformation
分子名称: ANTI-HIV-1 ANTIBODY 13H11 HEAVY CHAIN, ANTI-HIV-1 ANTIBODY 13H11 LIGHT CHAIN, SODIUM ION, ...
著者Nicely, N.I, Dennison, S.M, Kelsoe, G, Liao, H.-X, Alam, S.M, Haynes, B.F.
登録日2010-04-22
公開日2010-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of a Non-Neutralizing HIV-1 gp41 Envelope Antibody Demonstrates Neutralization Mechanism of gp41 Antibodies
To be Published
3VIE
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BU of 3vie by Molmil
HIV-gp41 fusion inhibitor Sifuvirtide
分子名称: Envelope glycoprotein gp160, Sifuvirtide
著者Yao, X, Waltersperger, S, Wang, M.T, Cui, S.
登録日2011-09-29
公開日2012-01-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide
J.Biol.Chem., 287, 2012

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