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PDB: 142 件
8D81
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BU of 8d81 by Molmil
Cereblon~DDB1 bound to Pomalidomide
分子名称: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
著者Watson, E.R, Lander, G.C.
登録日2022-06-07
公開日2022-07-20
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
6R8Z
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BU of 6r8z by Molmil
Cryo-EM structure of NCP_THF2(-1)-UV-DDB
分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ...
著者Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H.
登録日2019-04-02
公開日2019-06-12
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献DNA damage detection in nucleosomes involves DNA register shifting.
Nature, 571, 2019
6BN8
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BU of 6bn8 by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET55 PROTAC.
分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, ...
著者Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S.
登録日2017-11-16
公開日2018-06-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.990035 Å)
主引用文献Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
6R91
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BU of 6r91 by Molmil
Cryo-EM structure of NCP_THF2(-3)-UV-DDB
分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ...
著者Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H.
登録日2019-04-02
公開日2019-06-12
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献DNA damage detection in nucleosomes involves DNA register shifting.
Nature, 571, 2019
7V7B
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BU of 7v7b by Molmil
CryoEM structure of DDB1-VprBP complex in ARM-up conformation
分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1
著者Wang, D, Xu, J, Liu, Q, Xiang, Y.
登録日2021-08-21
公開日2022-08-31
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase
To Be Published
6H0G
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BU of 6h0g by Molmil
Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)
分子名称: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
著者Bunker, R.D, Petzold, G, Thoma, N.H.
登録日2018-07-09
公開日2018-11-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (4.25 Å)
主引用文献Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Science, 362, 2018
6R8Y
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BU of 6r8y by Molmil
Cryo-EM structure of NCP-6-4PP(-1)-UV-DDB
分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ...
著者Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H.
登録日2019-04-02
公開日2019-06-12
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献DNA damage detection in nucleosomes involves DNA register shifting.
Nature, 571, 2019
6BN9
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BU of 6bn9 by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET70 PROTAC
分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, ...
著者Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S.
登録日2017-11-16
公開日2018-05-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.382 Å)
主引用文献Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
8B3G
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BU of 8b3g by Molmil
C(N)RL4CSA-UVSSA-E2-ubiquitin complex.
分子名称: Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ...
著者Kokic, G, Cramer, P.
登録日2022-09-16
公開日2024-09-04
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair.
Nat.Struct.Mol.Biol., 31, 2024
6R90
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BU of 6r90 by Molmil
Cryo-EM structure of NCP-THF2(+1)-UV-DDB class A
分子名称: DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ...
著者Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H.
登録日2019-04-02
公開日2019-06-12
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献DNA damage detection in nucleosomes involves DNA register shifting.
Nature, 571, 2019
6R92
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BU of 6r92 by Molmil
Cryo-EM structure of NCP-THF2(+1)-UV-DDB class B
分子名称: DNA damage-binding protein 1,DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ...
著者Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H.
登録日2019-04-02
公開日2019-06-12
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献DNA damage detection in nucleosomes involves DNA register shifting.
Nature, 571, 2019
7ZNN
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BU of 7znn by Molmil
Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2
分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ...
著者Lauer, S, Spahn, C.M.T, Schwefel, D.
登録日2022-04-21
公開日2022-11-09
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
4A0K
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BU of 4a0k by Molmil
STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX
分子名称: 12 BP DNA, 12 BP THF CONTAINING DNA, CULLIN-4A, ...
著者Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H.
登録日2011-09-09
公開日2011-12-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (5.93 Å)
主引用文献The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
6BNB
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BU of 6bnb by Molmil
Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET57 PROTAC
分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ...
著者Nowak, R.P, DeAngelo, S.L, Buckley, D, Ishoey, M, He, Z, Zhang, T, Bradner, J.E, Fischer, E.S.
登録日2017-11-16
公開日2018-05-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (6.343 Å)
主引用文献Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14, 2018
4A0L
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BU of 4a0l by Molmil
Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex
分子名称: 12 BP DNA DUPLEX, 12 BP THF CONTAINING DNA DUPLEX, CULLIN-4B, ...
著者Fischer, E.S, Scrima, A, Gut, H, Thoma, N.H.
登録日2011-09-09
公開日2011-12-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (7.4 Å)
主引用文献The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
7OKQ
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BU of 7okq by Molmil
Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex
分子名称: Cullin-4A, DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, ...
著者Mohamed, W.I, Schenk, A.D, Kempf, G, Cavadini, S, Thoma, N.H.
登録日2021-05-18
公開日2021-10-13
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (8.4 Å)
主引用文献The CRL4 DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.
Embo J., 40, 2021
8AJO
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BU of 8ajo by Molmil
Negative-stain electron microscopy structure of DDB1-DCAF12-CCT5
分子名称: DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon
著者Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H.
登録日2022-07-28
公開日2022-11-09
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (30.6 Å)
主引用文献Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly.
Embo J., 42, 2023

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件を2024-09-18に公開中

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