8BU7
| Structure of DDB1 bound to 21195-engaged CDK12-cyclin K | 分子名称: | 1,2-ETHANEDIOL, 1-[2,6-bis(chloranyl)phenyl]-6-[[4-(2-hydroxyethyloxy)phenyl]methyl]-3-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.245 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUT
| Structure of DDB1 bound to DS61-engaged CDK12-cyclin K | 分子名称: | 2-[[6-[[4-(2-hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUE
| Structure of DDB1 bound to Z11-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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6H0F
| Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2) | 分子名称: | DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, DNA-binding protein Ikaros, Protein cereblon, ... | 著者 | Petzold, G, Bunker, R.D, Thoma, N.H. | 登録日 | 2018-07-09 | 公開日 | 2018-11-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science, 362, 2018
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8BUS
| Structure of DDB1 bound to DS59-engaged CDK12-cyclin K | 分子名称: | 1,3-dimethyl-5-[[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]methyl]pyrazole-4-sulfonamide, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8ROX
| Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12 | 分子名称: | 5-[[3,4-bis(chloranyl)-1~{H}-indol-7-yl]sulfamoyl]-~{N},~{N},3-trimethyl-furan-2-carboxamide;ethane, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... | 著者 | Shilliday, F, Lucas, S.C.C, Richter, M, Michaelides, I.N, Fusani, L. | 登録日 | 2024-01-12 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. J.Med.Chem., 67, 2024
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3EI4
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8TNP
| Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 | 分子名称: | DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8BUF
| Structure of DDB1 bound to Z12-engaged CDK12-cyclin K | 分子名称: | 2-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dimethoxy-3~{H}-quinazolin-4-one, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8UH6
| Degrader-induced complex between PTPN2 and CRBN-DDB1 | 分子名称: | (5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[(4-{1-[(3R)-2,6-dioxopiperidin-3-yl]-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}piperidine-1-carbonyl)amino]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid, DNA damage-binding protein 1, Protein cereblon, ... | 著者 | Catalano, C, Bratkowski, M, Scapin, G, Hao, Q. | 登録日 | 2023-10-06 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex. Commun Chem, 7, 2024
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4A11
| Structure of the hsDDB1-hsCSA complex | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, DNA EXCISION REPAIR PROTEIN ERCC-8 | 著者 | Bohm, K, Scrima, A, Fischer, E.S, Gut, H, Thomae, N.H. | 登録日 | 2011-09-13 | 公開日 | 2011-12-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | 主引用文献 | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. Cell(Cambridge,Mass.), 147, 2011
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6BOY
| Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET6 PROTAC. | 分子名称: | 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(8-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}octyl)acetamide, Bromodomain-containing protein 4, DNA damage-binding protein 1, ... | 著者 | Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. | 登録日 | 2017-11-21 | 公開日 | 2018-05-30 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | 主引用文献 | Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
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8BUM
| Structure of DDB1 bound to DS15-engaged CDK12-cyclin K | 分子名称: | (2R)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-20 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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3I8E
| Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR42A | 分子名称: | DNA damage-binding protein 1, WD repeat-containing protein 42A | 著者 | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | 登録日 | 2009-07-09 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Nat.Struct.Mol.Biol., 17, 2010
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8QH5
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8D7Y
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8BUL
| Structure of DDB1 bound to DS11-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8CVP
| Cereblon-DDB1 in the Apo form | 分子名称: | DNA damage-binding protein 1, Protein cereblon, ZINC ION | 著者 | Watson, E.R, Lander, G.C. | 登録日 | 2022-05-18 | 公開日 | 2022-07-20 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
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8D7X
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8BUP
| Structure of DDB1 bound to DS30-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUK
| Structure of DDB1 bound to DS08-engaged CDK12-cyclin K | 分子名称: | (2~{R})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, CITRIC ACID, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BU3
| Structure of DDB1 bound to DS19-engaged CDK12-cyclin K | 分子名称: | 1,2-ETHANEDIOL, 2-morpholin-4-yl-9-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]purin-6-amine, Cyclin-K, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8BUB
| Structure of DDB1 bound to dCeMM4-engaged CDK12-cyclin K | 分子名称: | CITRIC ACID, Cyclin-K, Cyclin-dependent kinase 12, ... | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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8G66
| Structure with SJ3149 | 分子名称: | (3S)-3-{5-[(1,2-benzoxazol-3-yl)amino]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}piperidine-2,6-dione, Casein kinase I isoform alpha, DNA damage-binding protein 1, ... | 著者 | Miller, D.J, Young, S.M, Fischer, M. | 登録日 | 2023-02-14 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Structure of ternary complex with molecular glue targeting CK1A for degradation by the CRL4CRBN ubiquitin ligase To Be Published
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8BU6
| Structure of DDB1 bound to DS55-engaged CDK12-cyclin K | 分子名称: | Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... | 著者 | Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. | 登録日 | 2022-11-30 | 公開日 | 2023-09-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
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