7OO3
 
 | | Pol II-CSB-CSA-DDB1-UVSSA (Structure1) | | 分子名称: | CSB element, DNA damage-binding protein 1, DNA excision repair protein ERCC-6, ... | | 著者 | Kokic, G, Cramer, P. | | 登録日 | 2021-05-26 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis of human transcription-DNA repair coupling.
Nature, 598, 2021
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2B5N
 | | Crystal Structure of the DDB1 BPB Domain | | 分子名称: | ISOPROPYL ALCOHOL, damage-specific DNA binding protein 1 | | 著者 | Li, T, Chen, X, Garbutt, K.C, Zhou, P, Zheng, N. | | 登録日 | 2005-09-28 | | 公開日 | 2006-02-28 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.
Cell(Cambridge,Mass.), 124, 2006
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8AJM
 | | Structure of human DDB1-DCAF12 in complex with the C-terminus of CCT5 | | 分子名称: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | | 著者 | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | | 登録日 | 2022-07-28 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly.
Embo J., 42, 2023
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4E54
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2B5L
 | | Crystal Structure of DDB1 In Complex with Simian Virus 5 V Protein | | 分子名称: | Nonstructural protein V, ZINC ION, damage-specific DNA binding protein 1 | | 著者 | Li, T, Chen, X, Garbutt, K.C, Zhou, P, Zheng, N. | | 登録日 | 2005-09-28 | | 公開日 | 2006-02-28 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.
Cell(Cambridge,Mass.), 124, 2006
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3I7H
 | | Crystal Structure of DDB1 in Complex with the H-Box Motif of HBX | | 分子名称: | DNA damage-binding protein 1, X protein | | 著者 | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | | 登録日 | 2009-07-08 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.
Nat.Struct.Mol.Biol., 17, 2010
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6PAI
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7OOP
 | | Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3) | | 分子名称: | DNA damage-binding protein 1, DNA excision repair protein ERCC-6, DNA excision repair protein ERCC-8, ... | | 著者 | Kokic, G, Cramer, P. | | 登録日 | 2021-05-28 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of human transcription-DNA repair coupling.
Nature, 598, 2021
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6Q0W
 | | Structure of DDB1-DDA1-DCAF15 complex bound to Indisulam and RBM39 | | 分子名称: | DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ... | | 著者 | Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. | | 登録日 | 2019-08-02 | | 公開日 | 2019-11-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.
Nat.Chem.Biol., 16, 2020
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6Q0R
 | | Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39 | | 分子名称: | 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... | | 著者 | Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. | | 登録日 | 2019-08-02 | | 公開日 | 2019-11-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.
Nat.Chem.Biol., 16, 2020
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6Q0V
 | | Structure of DDB1-DDA1-DCAF15 complex bound to tasisulam and RBM39 | | 分子名称: | DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ... | | 著者 | Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. | | 登録日 | 2019-08-02 | | 公開日 | 2019-11-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.
Nat.Chem.Biol., 16, 2020
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7UKN
 | | Crystal Structure of DDB1 in Complex with the H-Box Motif of pUL145 | | 分子名称: | DNA damage-binding protein 1, H-Box Motif of pUL145 | | 著者 | Wick, E.T, Treadway, C.J, Nicely, N.I, Li, Z, Ren, Z, Baldwin, A.S, Xiong, Y, Harrison, J.S, Brown, N.G. | | 登録日 | 2022-04-01 | | 公開日 | 2022-08-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex.
J.Virol., 96, 2022
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8U16
 | | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide | | 分子名称: | 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... | | 著者 | Clifton, M.C, Ma, X, Ornelas, E. | | 登録日 | 2023-08-30 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
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6FCV
 | | Structure of the human DDB1-CSA complex | | 分子名称: | DNA damage-binding protein 1, DNA excision repair protein ERCC-8 | | 著者 | Meulenbroek, E.M, Pannu, N.S. | | 登録日 | 2017-12-21 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.
Nat Commun, 9, 2018
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2B5M
 | | Crystal Structure of DDB1 | | 分子名称: | damage-specific DNA binding protein 1 | | 著者 | Li, T, Chen, X, Garbutt, K.C, Zhou, P, Zheng, N. | | 登録日 | 2005-09-28 | | 公開日 | 2006-02-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.
Cell(Cambridge,Mass.), 124, 2006
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4CI2
 | | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide | | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ... | | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | | 登録日 | 2013-12-05 | | 公開日 | 2014-07-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
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8U15
 | | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220 | | 分子名称: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DDB1, Protein cereblon, ... | | 著者 | Clifton, M.C, Ma, X, Ornelas, E. | | 登録日 | 2023-08-30 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
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8BU1
 | | Structure of DDB1 bound to DS17-engaged CDK12-cyclin K | | 分子名称: | (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... | | 著者 | Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. | | 登録日 | 2022-11-30 | | 公開日 | 2023-09-13 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Design principles for cyclin K molecular glue degraders.
Nat.Chem.Biol., 20, 2024
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4CI1
 | | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide | | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ... | | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | | 登録日 | 2013-12-05 | | 公開日 | 2014-07-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
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3I89
 | | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR22 | | 分子名称: | DNA damage-binding protein 1, WD repeat-containing protein 22 | | 著者 | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | | 登録日 | 2009-07-09 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.
Nat.Struct.Mol.Biol., 17, 2010
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8AJN
 | | Structure of the human DDB1-DCAF12 complex | | 分子名称: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1 | | 著者 | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | | 登録日 | 2022-07-28 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly.
Embo J., 42, 2023
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7OPD
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7OPC
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4A08
 | | Structure of hsDDB1-drDDB2 bound to a 13 bp CPD-duplex (purine at D-1 position) at 3.0 A resolution (CPD 1) | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-D(*AP*CP*GP*CP*GP*AP*(TTD)P*GP*CP*GP*CP*CP*C)-3', 5'-D(*TP*GP*GP*GP*CP*GP*CP*CP*CP*TP*CP*GP*CP*G)-3', ... | | 著者 | Scrima, A, Fischer, E.S, Iwai, S, Gut, H, Thoma, N.H. | | 登録日 | 2011-09-08 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation
Cell(Cambridge,Mass.), 147, 2011
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3I7P
 | | Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR40A | | 分子名称: | DNA damage-binding protein 1, WD repeat-containing protein 40A | | 著者 | Li, T, Robert, E.I, Breugel, P.C.V, Strubin, M, Zheng, N. | | 登録日 | 2009-07-08 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.
Nat.Struct.Mol.Biol., 17, 2010
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