3TDU
 
 | | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: Structure of a human Cul1WHB-Dcn1P-acetylated Ubc12N complex | | 分子名称: | Cullin-1, DCN1-like protein 1, NEDD8-conjugating enzyme Ubc12 | | 著者 | Scott, D.C, Monda, J.K, Bennett, E.J, Harper, J.W, Schulman, B.A. | | 登録日 | 2011-08-11 | | 公開日 | 2011-10-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex.
Science, 334, 2011
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5V89
 | | Structure of DCN4 PONY domain bound to CUL1 WHB | | 分子名称: | Cullin-1, DCN1-like protein 4 | | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | | 登録日 | 2017-03-21 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
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3TDZ
 | | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: Structure of a human Cul1WHB-Dcn1P-stapled acetylated Ubc12N complex | | 分子名称: | Cullin-1, DCN1-like protein 1, STAPLED PEPTIDE | | 著者 | Scott, D.C, Monda, J.K, Bennett, E.J, Harper, J.W, Schulman, B.A. | | 登録日 | 2011-08-11 | | 公開日 | 2011-10-12 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex.
Science, 334, 2011
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8CAF
 | | N8C_Fab3b in complex with NEDD8-CUL1(WHB) | | 分子名称: | Cullin-1, Fab Heavy Chain, Fab Light Chain, ... | | 著者 | Duda, D.M, Yanishevski, D, Henneberg, L.T, Schulman, B.A. | | 登録日 | 2023-01-24 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | | 主引用文献 | Activity-based profiling of cullin-RING E3 networks by conformation-specific probes.
Nat.Chem.Biol., 19, 2023
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7Z8R
 | | CAND1-CUL1-RBX1 | | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Baek, K, Schulman, B.A. | | 登録日 | 2022-03-18 | | 公開日 | 2023-04-19 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
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7Z8V
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8OR3
 | | CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 | | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, DCN1-like protein 1, ... | | 著者 | Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. | | 登録日 | 2023-04-13 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.
Mol.Cell, 83, 2023
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4F52
 | | Structure of a Glomulin-RBX1-CUL1 complex | | 分子名称: | Cullin-1, E3 ubiquitin-protein ligase RBX1, Glomulin, ... | | 著者 | Duda, D.M, Olszewski, J.L, Schulman, B.A. | | 登録日 | 2012-05-11 | | 公開日 | 2012-09-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface.
Mol.Cell, 47, 2012
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7Z8T
 | | CAND1-SCF-SKP2 CAND1 engaged SCF rocked | | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Baek, K, Schulman, B.A. | | 登録日 | 2022-03-18 | | 公開日 | 2023-04-19 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
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1LDJ
 | | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | | 分子名称: | Cullin homolog 1, ZINC ION, ring-box protein 1 | | 著者 | Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P. | | 登録日 | 2002-04-08 | | 公開日 | 2002-05-08 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
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1U6G
 | | Crystal Structure of The Cand1-Cul1-Roc1 Complex | | 分子名称: | Cullin homolog 1, RING-box protein 1, TIP120 protein, ... | | 著者 | Goldenberg, S.J, Shumway, S.D, Cascio, T.C, Garbutt, K.C, Liu, J, Xiong, Y, Zheng, N. | | 登録日 | 2004-07-29 | | 公開日 | 2004-12-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
Cell(Cambridge,Mass.), 119, 2004
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7ZBZ
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1LDK
 | | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | | 分子名称: | CULLIN HOMOLOG, CYCLIN A/CDK2-ASSOCIATED PROTEIN P19, SKP2-like protein type gamma, ... | | 著者 | Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P. | | 登録日 | 2002-04-08 | | 公開日 | 2002-05-08 | | 最終更新日 | 2019-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
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8OR0
 | | CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 | | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, Cyclin-dependent kinase 2, ... | | 著者 | Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. | | 登録日 | 2023-04-12 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.
Mol.Cell, 83, 2023
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4P5O
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8OR2
 | | CAND1-CUL1-RBX1-DCNL1 | | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, DCN1-like protein 1, ... | | 著者 | Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. | | 登録日 | 2023-04-12 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.
Mol.Cell, 83, 2023
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3RTR
 | | A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases | | 分子名称: | Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION | | 著者 | Calabrese, M.F, Scott, D.C, Duda, D.M, Grace, C.R, Kurinov, I, Kriwacki, R.W, Schulman, B.A. | | 登録日 | 2011-05-03 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | | 主引用文献 | A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
Nat.Struct.Mol.Biol., 18, 2011
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8CDK
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8CDJ
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7ZBW
 | | CAND1-SCF-SKP2 CAND1 rolling-2 SCF engaged | | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Baek, K, Schulman, B.A. | | 登録日 | 2022-03-24 | | 公開日 | 2023-04-19 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
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7B5N
 | | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-UBE2L3~Ub~ARIH1. | | 分子名称: | 5-azanylpentan-2-one, Cullin-1, E3 ubiquitin-protein ligase ARIH1, ... | | 著者 | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | | 登録日 | 2020-12-05 | | 公開日 | 2021-02-10 | | 最終更新日 | 2021-03-10 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
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7B5S
 | | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 | | 分子名称: | Cullin-1, E3 ubiquitin-protein ligase ARIH1, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | | 登録日 | 2020-12-07 | | 公開日 | 2021-02-10 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
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6TTU
 | | Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2 | | 分子名称: | CYS-LYS-LYS-ALA-ARG-HIS-ASP-SEP-GLY, Cullin-1, E3 ubiquitin-protein ligase RBX1, ... | | 著者 | Baek, K, Prabu, J.R, Schulman, B.A. | | 登録日 | 2019-12-30 | | 公開日 | 2020-02-12 | | 最終更新日 | 2020-03-04 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Nature, 578, 2020
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7B5R
 | | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27 | | 分子名称: | Cullin-1, Cyclin-A2, Cyclin-dependent kinase 2, ... | | 著者 | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | | 登録日 | 2020-12-07 | | 公開日 | 2021-02-10 | | 最終更新日 | 2021-03-10 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
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7B5L
 | | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 | | 分子名称: | 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... | | 著者 | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | | 登録日 | 2020-12-04 | | 公開日 | 2021-02-10 | | 最終更新日 | 2021-03-10 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Nature, 590, 2021
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