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PDB: 159 件
5DNO
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BU of 5dno by Molmil
Crystal structure of Mmi1 YTH domain complex with RNA
分子名称: RNA (5'-R(*CP*UP*UP*AP*AP*AP*C)-3'), YTH domain-containing protein mmi1
著者Wang, C.Y, Zhu, Y.W, Wu, J.H, Shi, Y.Y.
登録日2015-09-10
公開日2016-04-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1
Nucleic Acids Res., 44, 2016
5DNP
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BU of 5dnp by Molmil
Crystal structure of Mmi1 YTH domain
分子名称: PHOSPHATE ION, YTH domain-containing protein mmi1
著者Wang, C.Y, Zhu, Y.W, Shi, Y.Y, Wu, J.H.
登録日2015-09-10
公開日2016-04-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1
Nucleic Acids Res., 44, 2016
6ZOT
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BU of 6zot by Molmil
Crystal structure of YTHDF3 YTH domain in complex with m6A RNA
分子名称: RNA, YTH domain-containing family protein 3
著者Bedi, R.K, Caflisch, A.
登録日2020-07-07
公開日2020-10-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural and Dynamic Insights into Redundant Function of YTHDF Proteins.
J.Chem.Inf.Model., 60, 2020
5EIP
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BU of 5eip by Molmil
apo-structure of YTH domain of SpMmi1
分子名称: YTH domain-containing protein mmi1
著者Wu, B.X, Xu, J.H, Su, S.C, Ma, J.B.
登録日2015-10-30
公開日2016-01-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1
Biochem. Biophys. Res. Commun., 491, 2017
5EIM
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BU of 5eim by Molmil
YTH domain-containing protein mmi1 and RNA complex
分子名称: RNA (5'-R(*AP*UP*UP*AP*AP*AP*CP*A)-3'), YTH domain-containing protein mmi1
著者Wu, B.X, Xu, J.H, Su, S.C, Ma, J.B.
登録日2015-10-30
公開日2016-01-27
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1
Biochem. Biophys. Res. Commun., 491, 2017
6YL8
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BU of 6yl8 by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_011
分子名称: (2~{R},5~{S})-2-(2-chlorophenyl)-5-methyl-morpholine, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-06
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YNO
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BU of 6yno by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_139
分子名称: 6-[[methyl-[(1-phenylpyrazol-3-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
6YM2
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Crystal structure of YTHDC1 with compound ADO_AC_25
分子名称: SULFATE ION, YTHDC1, ~{N},9-dimethylpurin-6-amine
著者Bedi, R.K, Li, Y, Dolbois, A, Wiedmer, L, Caflisch, A.
登録日2020-04-07
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of YTHDC1 with compound ADO_AC_25
To Be Published
7QKN
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BU of 7qkn by Molmil
Crystal structure of YTHDF1 YTH domain in complex with the ebsulfur derivative compound 7
分子名称: 1,2-ETHANEDIOL, THIOCYANATE ION, YTH domain-containing family protein 1, ...
著者Dalle Vedove, A, Cazzanelli, G, Quattrone, A, Provenzani, A, Lolli, G.
登録日2021-12-18
公開日2022-11-23
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs.
Acs Pharmacol Transl Sci, 5, 2022
6YM8
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Crystal structure of YTHDC1 with compound YLI_DC1_002
分子名称: 2-chloranyl-~{N}-methyl-9~{H}-purin-6-amine, SULFATE ION, YTHDC1
著者Bedi, R.K, Li, Y, Wiedmer, L, Caflisch, A.
登録日2020-04-07
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of YTHDC1 with compound YLI_DC1_002
To Be Published
7QL7
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BU of 7ql7 by Molmil
Crystal structure of YTHDF1 YTH domain in complex with the ebsulfur derivative compound 9
分子名称: 1,2-ETHANEDIOL, THIOCYANATE ION, YTH domain-containing family protein 1, ...
著者Dalle Vedove, A, Cazzanelli, G, Quattrone, A, Provenzani, A, Lolli, G.
登録日2021-12-19
公開日2022-11-23
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6 -Methyladenosine-Modified RNAs.
Acs Pharmacol Transl Sci, 5, 2022
6ZD9
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BU of 6zd9 by Molmil
Crystal structure of YTHDC1 apo purified using GST tag
分子名称: DI(HYDROXYETHYL)ETHER, SULFATE ION, YTHDC1
著者Bedi, R.K, Caflisch, A.
登録日2020-06-14
公開日2020-07-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
7R5F
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BU of 7r5f by Molmil
Crystal structure of YTHDF2 with compound YLI_DF_012
分子名称: 5-azanyl-6-methyl-1~{H}-pyrimidine-2,4-dione, CHLORIDE ION, SULFATE ION, ...
著者Nai, F, Li, Y, Caflisch, A.
登録日2022-02-10
公開日2022-03-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Acs Med.Chem.Lett., 13, 2022
7R5L
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BU of 7r5l by Molmil
Crystal structure of YTHDF2 with compound YLI_DC1_015
分子名称: 3,6-dimethyl-2~{H}-1,2,4-triazin-5-one, SULFATE ION, YTH domain-containing family protein 2
著者Nachawati, R, Nai, F, Li, Y, Caflisch, A.
登録日2022-02-10
公開日2022-03-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Acs Med.Chem.Lett., 13, 2022
7R5W
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BU of 7r5w by Molmil
Crystal structure of YTHDF2 with compound YLI_DF_029
分子名称: 6-cyclopropyl-1H-pyrimidine-2,4-dione, CHLORIDE ION, GLYCEROL, ...
著者Nai, F, Li, Y, Caflisch, A.
登録日2022-02-11
公開日2022-03-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Acs Med.Chem.Lett., 13, 2022
4RCJ
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BU of 4rcj by Molmil
Crystal structure of YTHDF1 YTH domain in complex with 5mer m6A RNA
分子名称: RNA (5'-R(*GP*GP*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION, YTH domain-containing family protein 1
著者Tempel, W, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2014-09-16
公開日2014-11-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.
J.Biol.Chem., 290, 2015
4RDO
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BU of 4rdo by Molmil
Structure of YTH-YTHDF2 in the free state
分子名称: SULFATE ION, YTH domain-containing family protein 2
著者Li, F.D, Zhao, D.B, Wu, J.H, Shi, Y.Y.
登録日2014-09-19
公開日2014-12-24
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition.
Cell Res., 24, 2014
4R3H
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BU of 4r3h by Molmil
The crystal structure of an apo RNA binding protein
分子名称: SULFATE ION, UNKNOWN ATOM OR ION, YTH domain-containing protein 1
著者Xu, C, Liu, K, Tempel, W, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2014-08-15
公開日2014-09-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.
Nat.Chem.Biol., 10, 2014
4RDN
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BU of 4rdn by Molmil
Structure of YTH-YTHDF2 in complex with m6A
分子名称: N-methyladenosine, SULFATE ION, YTH domain-containing family protein 2
著者Li, F.D, Zhao, D.B, Wu, J.H, Shi, Y.Y.
登録日2014-09-19
公開日2014-12-24
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition.
Cell Res., 24, 2014
4RCM
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BU of 4rcm by Molmil
Crystal structure of the Pho92 YTH domain in complex with m6A
分子名称: Methylated RNA-binding protein 1, RNA (5'-R(*UP*G)-D(*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION
著者Tempel, W, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2014-09-16
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.
J.Biol.Chem., 290, 2015
4RCI
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BU of 4rci by Molmil
Crystal structure of YTHDF1 YTH domain
分子名称: UNKNOWN ATOM OR ION, YTH domain-containing family protein 1
著者Xu, C, Tempel, W, Liu, K, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2014-09-16
公開日2014-10-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.
J.Biol.Chem., 290, 2015
4R3I
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BU of 4r3i by Molmil
The crystal structure of an RNA complex
分子名称: RNA (5'-R(*GP*GP*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION, YTH domain-containing protein 1
著者Tempel, W, Xu, C, Liu, K, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2014-08-15
公開日2014-09-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.
Nat.Chem.Biol., 10, 2014
4U8T
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BU of 4u8t by Molmil
Crystal structure of YTH domain of Zygosaccharomyces rouxii MRB1 protein in complex with N6-Methyladenosine RNA
分子名称: RNA (5'-R(*AP*GP*GP*(6MZ)P*CP*AP*U)-3'), ZYRO0G01672p
著者Luo, S, Tong, L.
登録日2014-08-04
公開日2014-09-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain.
Proc.Natl.Acad.Sci.USA, 111, 2014
6RT5
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BU of 6rt5 by Molmil
The YTH domain of YTHDC1 protein in complex with Gm6AC oligonucleotide
分子名称: RNA (5'-R(*(6MZ)P*C)-3'), SULFATE ION, YTH domain-containing protein 1
著者Bedi, R, Sledz, P, Caflisch, A.
登録日2019-05-22
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.303 Å)
主引用文献Flexible Binding of m6A Reader Protein YTHDC1 to Its Preferred RNA Motif.
J Chem Theory Comput, 15, 2019
6RT4
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The YTH domain of YTHDC1 protein in complex with m6ACU oligonucleotide
分子名称: RNA (5'-R(*(6MZ)P*C)-3'), SULFATE ION, YTH domain-containing protein 1
著者Bedi, R, Sledz, P, Caflisch, A.
登録日2019-05-22
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Flexible Binding of m6A Reader Protein YTHDC1 to Its Preferred RNA Motif.
J Chem Theory Comput, 15, 2019

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