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PDB: 238 件
6LZL
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Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine
分子名称: (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Liu, Z.H, Wu, D, Lu, W.Q, Huang, J.
登録日2020-02-19
公開日2020-04-15
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine
To Be Published
6AJ5
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Crystal structure of ligand-free type DHODH from Eimeria tenella
分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
著者Shiba, T, Inaoka, D.K, Sato, D, Hartuti, E.D, Amalia, E, Nagahama, M, Yoshioka, Y, Matsubayashi, M, Balogun, E.O, Tsuji, N, Kita, K, Harada, S.
登録日2018-08-27
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.
Genes (Basel), 11, 2020
6LP8
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Crystal structure of human DHODH in complex with inhibitor 1243
分子名称: 3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Chen, Q, Yu, Y.
登録日2020-01-09
公開日2020-09-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
8DHH
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DHODH IN COMPLEX WITH LIGAND 29
分子名称: (6M)-N-(3-chloro-2-methoxy-5-methylpyridin-4-yl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Shaffer, P.L.
登録日2022-06-27
公開日2022-08-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献N -Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.
J.Med.Chem., 65, 2022
8DHG
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DHODH IN COMPLEX WITH LIGAND 19
分子名称: (6M)-N-(2-chloro-4-methylpyridin-3-yl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Shaffer, P.L.
登録日2022-06-27
公開日2022-08-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献N -Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.
J.Med.Chem., 65, 2022
8DHF
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DHODH IN COMPLEX WITH LIGAND 11
分子名称: (6M)-N-(2-chloro-6-fluorophenyl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Shaffer, P.L.
登録日2022-06-27
公開日2022-08-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献N -Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.
J.Med.Chem., 65, 2022
6M2B
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Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416
分子名称: 2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Zhu, L, Li, H.
登録日2020-02-27
公開日2021-03-03
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Protein Cell, 11, 2020
6B8S
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Crystal Structure of Dihydroorotate Dehydrogenase from Helicobacter pylori with bound FMN
分子名称: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, TRIETHYLENE GLYCOL
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2017-10-09
公開日2017-11-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure of Dihydroorotate Dehydrogenase from Helicobacter pylori with bound FMN
to be published
1D3G
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HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG
分子名称: 2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARBOXYLIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ...
著者Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J.
登録日1999-09-29
公開日2000-09-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
6CJG
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Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 46
分子名称: 2-([1,1'-biphenyl]-4-yl)-3-methyl-1,7-naphthyridine-4-carboxylic acid, 3-[decyl(dimethyl)ammonio]propane-1-sulfonate, Dihydroorotate dehydrogenase (quinone), ...
著者Petrunak, E.M, Stuckey, J.A.
登録日2018-02-26
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.851 Å)
主引用文献Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
J. Med. Chem., 61, 2018
1D3H
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HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726
分子名称: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ...
著者Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J.
登録日1999-09-29
公開日2000-08-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8, 2000
6CJF
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Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43
分子名称: 2-[4-(2-chloro-6-methylpyridin-3-yl)phenyl]-6-fluoro-3-methylquinoline-4-carboxylic acid, 3-[decyl(dimethyl)ammonio]propane-1-sulfonate, Dihydroorotate dehydrogenase (quinone), ...
著者Petrunak, E.M, Stuckey, J.A.
登録日2018-02-26
公開日2018-05-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
J. Med. Chem., 61, 2018
6OC0
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Crystal structure of human DHODH with OSU-03012
分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
著者Durst, M.A, Lavie, A.
登録日2019-03-21
公開日2019-11-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
Cell Chem Biol, 27, 2020
6LP6
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Crystal structure of human DHODH in complex with inhibitor 1214
分子名称: 3-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
著者Chen, Q, Yu, Y.
登録日2020-01-09
公開日2020-09-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.795 Å)
主引用文献Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
1JQV
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BU of 1jqv by Molmil
The K213E mutant of Lactococcus lactis Dihydroorotate dehydrogenase A
分子名称: ACETIC ACID, Dihydroorotate dehydrogenase A, FLAVIN MONONUCLEOTIDE, ...
著者Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
登録日2001-08-09
公開日2003-09-09
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JRB
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The P56A mutant of Lactococcus lactis dihydroorotate dehydrogenase A
分子名称: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A
著者Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
登録日2001-08-13
公開日2003-09-09
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JUB
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The K136E mutant of lactococcus lactis dihydroorotate dehydrogenase A
分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ...
著者Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
登録日2001-08-24
公開日2003-09-09
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
6DGS
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Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant Y142A
分子名称: Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Reis, R.A.G, Pinheiro, M.P, Nonato, M.C.
登録日2018-05-18
公開日2019-05-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant Y142A
To Be Published
6DWG
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Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant Q139A
分子名称: Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Reis, R.A.G, Pinheiro, M.P, Nonato, M.C.
登録日2018-06-26
公開日2019-06-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant Q139A
To Be Published
1JQX
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The R57A mutant of Lactococcus lactis dihydroorotate dehydrogenase A
分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ...
著者Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
登録日2001-08-09
公開日2003-09-09
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JRC
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The N67A mutant of Lactococcus lactis dihydroorotate dehydrogenase A
分子名称: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A
著者Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
登録日2001-08-13
公開日2003-09-09
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1JUE
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1.8 A resolution structure of native lactococcus lactis dihydroorotate dehydrogenase A
分子名称: ACETIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S.
登録日2001-08-24
公開日2003-09-09
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J.Biol.Chem., 278, 2003
1DOR
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DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS
分子名称: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE
著者Rowland, P, Larsen, S.
登録日1997-01-14
公開日1997-04-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis.
Structure, 5, 1997
6J3B
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Crystal structure of human DHODH in complex with inhibitor 1289
分子名称: (6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, ACETATE ION, CHLORIDE ION, ...
著者Yu, Y, Chen, Q.
登録日2019-01-04
公開日2019-08-21
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
Febs Open Bio, 9, 2019
6J3C
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Crystal structure of human DHODH in complex with inhibitor 1291
分子名称: (6R)-1-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Yu, Y, Chen, Q.
登録日2019-01-04
公開日2019-08-21
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
Febs Open Bio, 9, 2019

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