6DTA
 
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6DT8
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6DT7
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7PZP
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1CEZ
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5OLA
 | | Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM | | 分子名称: | DNA (30-MER), DNA (5'-D(P*AP*TP*GP*GP*TP*GP*TP*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*GP*AP*AP*C)-3'), DNA-directed RNA polymerase, ... | | 著者 | Hillen, H.S, Parshin, A.V, Agaronyan, K, Morozov, Y, Graber, J.J, Chernev, A, Schwinghammer, K, Urlaub, H, Anikin, M, Cramer, P, Temiakov, D. | | 登録日 | 2017-07-27 | | 公開日 | 2017-10-18 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.904 Å) | | 主引用文献 | Mechanism of Transcription Anti-termination in Human Mitochondria.
Cell, 171, 2017
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1H38
 | | Structure of a T7 RNA polymerase elongation complex at 2.9A resolution | | 分子名称: | 5'-D(*GP*GP*GP*AP*AP*TP*CP*GP*AP*CP *AP*TP*CP*GP*CP*CP*GP*C)-3', 5'-D(*GP*TP*CP*GP*AP*TP*TP*CP*CP*CP)-3', 5'-R(*AP*AP*CP*UP*GP*CP*GP*GP*CP*GP *AP*U)-3', ... | | 著者 | Tahirov, T.H, Temyakov, D, Anikin, M, Patlan, V, McAllister, W.T, Vassylyev, D.G, Yokoyama, S. | | 登録日 | 2002-08-24 | | 公開日 | 2002-11-20 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of a T7 RNA Polymerase Elongation Complex at 2.9 A Resolution
Nature, 420, 2002
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3SPA
 | | Crystal Structure of Human Mitochondrial RNA Polymerase | | 分子名称: | CHLORIDE ION, DNA-directed RNA polymerase, mitochondrial, ... | | 著者 | Ringel, R, Sologub, M, Morozov, Y.I, Litonin, D, Cramer, P, Temiakov, D. | | 登録日 | 2011-07-01 | | 公開日 | 2011-09-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of human mitochondrial RNA polymerase
Nature, 478, 2011
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7PZR
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4BOC
 | | Structure of mitochondrial RNA polymerase elongation complex | | 分子名称: | 5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3', 5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3', ... | | 著者 | Schwinghammer, K, Cheung, A, Morozov, Y, Agaronyan, K, Temiakov, D, Cramer, P. | | 登録日 | 2013-05-18 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structure of Human Mitochondrial RNA Polymerase Elongation Complex
Nat.Struct.Mol.Biol., 20, 2013
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1MSW
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4RNP
 | | BACTERIOPHAGE T7 RNA POLYMERASE, HIGH SALT CRYSTAL FORM, LOW TEMPERATURE DATA, ALPHA-CARBONS ONLY | | 分子名称: | RNA POLYMERASE | | 著者 | Liu, Z.J, Sousa, R, Rose, J.P, Wang, B.C. | | 登録日 | 1997-09-11 | | 公開日 | 1997-12-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of bacteriophage T7 RNA polymerase at 3.3 A resolution.
Nature, 364, 1993
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7ZC4
 | | Cryo-EM structure of POLRMT mutant. | | 分子名称: | DNA-directed RNA polymerase, mitochondrial | | 著者 | Das, H, Hallberg, B.M. | | 登録日 | 2022-03-25 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization.
Cell, 185, 2022
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9BDC
 | | Cryo-EM Structure of the TEFM bound Human Mitochondrial Transcription Elongation Complex in a Closed Fingers Domain Conformation | | 分子名称: | DNA-directed RNA polymerase, mitochondrial, Non-Template Strand DNA (NT27mt_+1T), ... | | 著者 | Herbine, K.H, Nayak, A.R, Temiakov, D. | | 登録日 | 2024-04-11 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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9BDD
 | | Cryo-EM Structure of Non-Cognate Substrate Bound in the Entry Site (ES) of Human Mitochondrial Transcription Elongation Complex | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ... | | 著者 | Herbine, K.H, Nayak, A.R, Temiakov, D. | | 登録日 | 2024-04-11 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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7A8P
 | | Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor. | | 分子名称: | (3~{R})-1-[(2~{R})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid, DNA-directed RNA polymerase, mitochondrial | | 著者 | Hillen, H.S, Bonekamp, N, Peter, B, Felser, A, Bergbrede, T, Choidas, A, Horn, M, Unger, A, di Lucrezia, R, Atanassov, I, Li, X, Koch, U, Menninger, S, Boros, J, Habenberger, P, Giavalisco, P, Cramer, P, Denzel, M, Nussbaumer, P, Klebl, B, Falkenberg, M, Gustafsson, C.M, Larsson, N.G. | | 登録日 | 2020-08-30 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Small-molecule inhibitors of human mitochondrial DNA transcription.
Nature, 588, 2020
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8U8V
 | | Cryo-EM structure of Substrate ATP Bound in the Insertion Site (IS) of Human Mitochondrial Transcription Elongation Complex | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ... | | 著者 | Herbine, K.H, Nayak, A.R, Temiakov, D. | | 登録日 | 2023-09-18 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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8U8U
 | | Cryo-EM Structure of Cognate Substrate ATP Bound in the Entry Site (ES) of Human Mitochondrial Transcription Elongation Complex | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ... | | 著者 | Herbine, K.H, Nayak, A.R, Temiakov, D. | | 登録日 | 2023-09-18 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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3E3J
 | | Crystal Structure of an Intermediate Complex of T7 RNAP and 8nt of RNA | | 分子名称: | DNA (28-MER), DNA (5'-D(*DTP*DAP*DAP*DTP*DAP*DCP*DGP*DAP*DCP*DTP*DCP*DAP*DCP*DTP*DAP*DTP*DAP*DTP*DTP*DTP*DCP*DTP*DGP*DCP*DCP*DAP*DAP*DAP*DCP*DGP*DGP*DC)-3'), DNA-directed RNA polymerase, ... | | 著者 | Durniak, K.J, Bailey, S, Steitz, T.A. | | 登録日 | 2008-08-07 | | 公開日 | 2008-11-04 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (6.7 Å) | | 主引用文献 | The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation
Science, 322, 2008
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2PI5
 | | T7 RNA polymerase complexed with a phi10 promoter | | 分子名称: | 5'-D(*CP*TP*TP*C*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', DNA-directed RNA polymerase | | 著者 | Kennedy, W.P, Momand, J.R, Yin, Y.W. | | 登録日 | 2007-04-12 | | 公開日 | 2007-06-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase.
J.Mol.Biol., 370, 2007
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3E2E
 | | Crystal Structure of an Intermediate Complex of T7 RNAP and 7nt of RNA | | 分子名称: | DNA (28-MER), DNA (31-MER), DNA-directed RNA polymerase, ... | | 著者 | Durniak, K.J, Bailey, S, Steitz, T.A. | | 登録日 | 2008-08-05 | | 公開日 | 2008-11-04 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation
Science, 322, 2008
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2PI4
 | | T7RNAP complexed with a phi10 protein and initiating GTPs. | | 分子名称: | 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*CP*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', ... | | 著者 | Kennedy, W.P, Momand, J.R, Yin, Y.W. | | 登録日 | 2007-04-12 | | 公開日 | 2007-06-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase.
J.Mol.Biol., 370, 2007
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1ARO
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1QLN
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1S77
 | | T7 RNAP product pyrophosphate elongation complex | | 分子名称: | DNA (5'-D(*GP*CP*CP*GP*TP*GP*CP*GP*CP*AP*TP*TP*CP*GP*CP*CP*GP*TP*GP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*AP*CP*GP*TP*TP*GP*CP*GP*CP*AP*CP*GP*GP*C)-3'), DNA-directed RNA polymerase, ... | | 著者 | Yin, Y.W, Steitz, T.A. | | 登録日 | 2004-01-29 | | 公開日 | 2004-03-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
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