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PDB: 49 件
2XZZ
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Crystal structure of the human transglutaminase 1 beta-barrel domain
分子名称: PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE K
著者Vollmar, M, Krysztofinska, E, Krojer, T, Yue, W.W, Cooper, C, Kavanagh, K, Allerston, C, Chaikuad, A, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U.
登録日2010-11-30
公開日2011-01-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of the Human Transglutaminase 1 Beta-Barrel Domain
To be Published
6KZB
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Transglutaminase2 complexed with calcium
分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2
著者Park, H.H, Kim, C.M.
登録日2019-09-23
公開日2020-12-09
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2.
Int J Mol Sci, 21, 2020
3LY6
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Crystal structure of human transglutaminase 2 complex with adenosine 5' Triphosphate
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2
著者Han, B.G, Lee, B.I.
登録日2010-02-26
公開日2010-08-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献Crystal structure of human transglutaminase 2 in complex with adenosine triphosphate
Int.J.Biol.Macromol., 47, 2010
4KTY
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Fibrin-stabilizing factor with a bound ligand
分子名称: CALCIUM ION, Coagulation factor XIII A chain, GLYCEROL, ...
著者Stieler, M, Heine, A, Klebe, G.
登録日2013-05-21
公開日2013-12-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structure of Active Coagulation Factor XIII Triggered by Calcium Binding: Basis for the Design of Next-Generation Anticoagulants.
Angew.Chem.Int.Ed.Engl., 52, 2013
4PYG
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BU of 4pyg by Molmil
Transglutaminase2 complexed with GTP
分子名称: GUANOSINE-5'-TRIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2
著者Park, H.H, Jang, T.H.
登録日2014-03-27
公開日2015-02-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of transglutaminase 2 with GTP complex and amino acid sequence evidence of evolution of GTP binding site.
Plos One, 9, 2014
2Q3Z
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Transglutaminase 2 undergoes large conformational change upon activation
分子名称: Polypeptide, SULFATE ION, Transglutaminase 2
著者Strop, P, Pinkas, D.M, Brunger, A.T, Khosla, C.
登録日2007-05-30
公開日2007-10-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Transglutaminase 2 undergoes a large conformational change upon activation
Plos Biol., 5, 2007
8TR9
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BU of 8tr9 by Molmil
Cryo-EM structure of transglutaminase 2 bound to GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2
著者Aplin, C, Cerione, R.A.
登録日2023-08-09
公開日2024-07-31
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Conformational activation and inhibition of transglutaminase 2 determined by static and time resolved small-angle X-ray scattering and cryoelectron microscopy
To Be Published
6A8P
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Transglutaminase 2 mutant G224V in complex with GTP
分子名称: GUANOSINE-5'-TRIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2
著者Park, H.H, Ha, H.J, Kwon, S.
登録日2018-07-09
公開日2018-09-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.537 Å)
主引用文献Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity.
PLoS ONE, 13, 2018
1QRK
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HUMAN FACTOR XIII WITH STRONTIUM BOUND IN THE ION SITE
分子名称: PROTEIN (COAGULATION FACTOR XIII), STRONTIUM ION
著者Fox, B.A, Yee, V.C, Pederson, L.C, Le Trong, I, Bishop, P.D, Stenkamp, R.E, Teller, D.C.
登録日1999-06-14
公開日1999-07-02
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography.
J.Biol.Chem., 274, 1999
3S3J
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Transglutaminase 2 in complex with a novel inhibitor
分子名称: GLYCEROL, Peptide inhibitor, Protein-glutamine gamma-glutamyltransferase 2, ...
著者Lindemann, I, Heine, A, Klebe, G.
登録日2011-05-18
公開日2012-06-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Inhibitors of Transglutaminase 2: A therapeutic option in celiac disease
To be Published
3S3S
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Transglutaminase 2 in complex with a novel inhibitor
分子名称: Protein-glutamine gamma-glutamyltransferase 2, SULFATE ION, peptide inhibitor
著者Lindemann, I, Heine, A, Klebe, G.
登録日2011-05-18
公開日2012-06-06
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Inhibitors of Transglutaminase 2: A therapeutic option in celiac disease
To be Published
3S3P
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Transglutaminase 2 in complex with a novel inhibitor
分子名称: Peptide inhibitor, Protein-glutamine gamma-glutamyltransferase 2, SULFATE ION
著者Lindemann, I, Heine, A, Klebe, G.
登録日2011-05-18
公開日2012-06-06
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Transglutaminase 2 in complex with a novel inhibitor
To be Published
9BC2
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Transglutaminase 2 - Open State
分子名称: CHLORIDE ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2, ...
著者Mathews, I.I, Sewa, A, Khosla, C.
登録日2024-04-07
公開日2024-07-03
最終更新日2024-07-17
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state.
Proc.Natl.Acad.Sci.USA, 121, 2024
9BC4
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Transglutaminase 2 - Intermediate State
分子名称: CALCIUM ION, GLYCEROL, HB-225 (gluten peptidomimetic TG2 inhibitor), ...
著者Sewa, A.S, Mathews, I.I, Khosla, C.
登録日2024-04-07
公開日2024-07-03
最終更新日2024-07-17
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state.
Proc.Natl.Acad.Sci.USA, 121, 2024
9BC3
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Transglutaminase 2 - Alternate state
分子名称: CALCIUM ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2
著者Mathews, I.I, Sewa, A.S, Khosla, C.
登録日2024-04-07
公開日2024-07-03
最終更新日2024-07-17
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state.
Proc.Natl.Acad.Sci.USA, 121, 2024
8OXW
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BU of 8oxw by Molmil
Transglutaminase 3 in complex with DH patient-derived Fab DH63-B02
分子名称: 1,2-ETHANEDIOL, Antibody fab fragment heavy chain, Antibody fab fragment light chain, ...
著者Heggelund, J.E, Sollid, L.M.
登録日2023-05-02
公開日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.
Nat Commun, 14, 2023
8OXV
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Transglutaminase 3 zymogen in complex with DH patient-derived Fab DH63-B02
分子名称: 1,2-ETHANEDIOL, Antibody Fab fragment Heavy chain, Antibody Fab fragment light chain, ...
著者Heggelund, J.E, Sollid, L.M.
登録日2023-05-02
公開日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.
Nat Commun, 14, 2023
8OXY
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BU of 8oxy by Molmil
Transglutaminase 3 without calcium in complex with DH patient-derived Fab DH63-B02
分子名称: 1,2-ETHANEDIOL, Antibody fab fragment heavy chain, Antibody fab fragment light chain, ...
著者Heggelund, J.E, Sollid, L.M.
登録日2023-05-02
公開日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.
Nat Commun, 14, 2023
1EX0
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BU of 1ex0 by Molmil
HUMAN FACTOR XIII, MUTANT W279F ZYMOGEN
分子名称: CALCIUM ION, COAGULATION FACTOR XIII A CHAIN, PHOSPHATE ION, ...
著者Garzon, R.J, Pratt, K.P, Bishop, P.D, Le Trong, I, Stenkamp, R.E, Teller, D.C.
登録日2000-04-28
公開日2003-12-23
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Tryptophan 279 is Essential for the Transglutaminase Activity of Coagulation Factor XIII: Functional and Structural Characterization
To be Published
1EVU
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BU of 1evu by Molmil
HUMAN FACTOR XIII WITH CALCIUM BOUND IN THE ION SITE
分子名称: CALCIUM ION, COAGULATION FACTOR XIII, S-1,2-PROPANEDIOL
著者Garzon, R.J, Pratt, K.P, Bishop, P.D, Le Trong, I, Stenkamp, R.E, Teller, D.C.
登録日2000-04-20
公開日2000-05-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Tryptophan 279 is Essential for the Transglutaminase Activity of Coagulation Factor XIII: Functional and Structural Characterization
To Be Published
1F13
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RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII
分子名称: CELLULAR COAGULATION FACTOR XIII ZYMOGEN
著者Weiss, M.S, Hilgenfeld, R.
登録日1998-01-16
公開日1998-08-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Two non-proline cis peptide bonds may be important for factor XIII function.
FEBS Lett., 423, 1998
5MHM
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BU of 5mhm by Molmil
FXIIIa in complex with the inhibitor ZED1630
分子名称: CALCIUM ION, CHLORIDE ION, Coagulation factor XIII A chain, ...
著者Stieler, M, Heine, A, Klebe, G.
登録日2016-11-24
公開日2017-12-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献FXIIIa in complex with the inhibitor Mi0621
To Be Published
5MHO
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FXIIIa in complex with the inhibitor ZED2369
分子名称: CALCIUM ION, Coagulation factor XIII A chain, SULFATE ION, ...
著者Stieler, M, Heine, A, Klebe, G.
登録日2016-11-24
公開日2017-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献FXIIIa in complex with the inhibitor ZED2369
To Be Published
5MHN
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FXIIIa in complex with the inhibitor ZED2360
分子名称: CALCIUM ION, Coagulation factor XIII A chain, GLYCEROL, ...
著者Stieler, M, Heine, A, Klebe, G.
登録日2016-11-24
公開日2017-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献FXIIIa in complex with the inhibitor Mi0621
To Be Published
8CSL
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Sub-tomogram averaging of erythrocyte ankyrin-1 complex
分子名称: Ammonium transporter Rh type A, Ankyrin-1, Band 3 anion transport protein, ...
著者Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B.
登録日2022-05-12
公開日2022-07-20
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (25 Å)
主引用文献Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022

 

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