8OXV

Transglutaminase 3 zymogen in complex with DH patient-derived Fab DH63-B02

Summary for 8OXV

Entry DOI	10.2210/pdb8oxv/pdb
Descriptor	Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain, Antibody Fab fragment Heavy chain, Antibody Fab fragment light chain, ... (7 entities in total)
Functional Keywords	transglutaminase, tgm3, tg3, transglutaminase 3, enzyme, zymogen, antibody, dermatitis herpetiformis, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	124310.81
Authors	Heggelund, J.E.,Sollid, L.M. (deposition date: 2023-05-02, release date: 2023-10-18)
Primary citation	Heggelund, J.E.,Das, S.,Stamnaes, J.,Iversen, R.,Sollid, L.M. Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3. Nat Commun, 14:6216-6216, 2023 Cited by PubMed: 37798283 DOI: 10.1038/s41467-023-42004-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation