8OXY

Transglutaminase 3 without calcium in complex with DH patient-derived Fab DH63-B02

Summary for 8OXY

Entry DOI	10.2210/pdb8oxy/pdb
Descriptor	Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain, Antibody fab fragment heavy chain, Antibody fab fragment light chain, ... (6 entities in total)
Functional Keywords	transglutaminase, tgm3, tg3, transglutaminase 3, enzyme, antibody, dermatitis herpetiformis, ighv3-9, iglv6-57, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	124746.64
Authors	Heggelund, J.E.,Sollid, L.M. (deposition date: 2023-05-02, release date: 2023-10-18)
Primary citation	Heggelund, J.E.,Das, S.,Stamnaes, J.,Iversen, R.,Sollid, L.M. Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3. Nat Commun, 14:6216-6216, 2023 Cited by PubMed: 37798283 DOI: 10.1038/s41467-023-42004-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation