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PDB: 45 件

6A8P
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Transglutaminase 2 mutant G224V in complex with GTP
分子名称: GUANOSINE-5'-TRIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2
著者Park, H.H, Ha, H.J, Kwon, S.
登録日2018-07-09
公開日2018-09-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.537 Å)
主引用文献Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity.
PLoS ONE, 13, 2018
6KZB
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Transglutaminase2 complexed with calcium
分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2
著者Park, H.H, Kim, C.M.
登録日2019-09-23
公開日2020-12-09
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Competitive Binding of Magnesium to Calcium Binding Sites Reciprocally Regulates Transamidase and GTP Hydrolysis Activity of Transglutaminase 2.
Int J Mol Sci, 21, 2020
4PYG
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Transglutaminase2 complexed with GTP
分子名称: GUANOSINE-5'-TRIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2
著者Park, H.H, Jang, T.H.
登録日2014-03-27
公開日2015-02-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of transglutaminase 2 with GTP complex and amino acid sequence evidence of evolution of GTP binding site.
Plos One, 9, 2014
4KTY
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Fibrin-stabilizing factor with a bound ligand
分子名称: CALCIUM ION, Coagulation factor XIII A chain, GLYCEROL, ...
著者Stieler, M, Heine, A, Klebe, G.
登録日2013-05-21
公開日2013-12-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structure of Active Coagulation Factor XIII Triggered by Calcium Binding: Basis for the Design of Next-Generation Anticoagulants.
Angew.Chem.Int.Ed.Engl., 52, 2013
2Q3Z
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Transglutaminase 2 undergoes large conformational change upon activation
分子名称: Polypeptide, SULFATE ION, Transglutaminase 2
著者Strop, P, Pinkas, D.M, Brunger, A.T, Khosla, C.
登録日2007-05-30
公開日2007-10-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Transglutaminase 2 undergoes a large conformational change upon activation
Plos Biol., 5, 2007
3LY6
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Crystal structure of human transglutaminase 2 complex with adenosine 5' Triphosphate
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 2
著者Han, B.G, Lee, B.I.
登録日2010-02-26
公開日2010-08-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献Crystal structure of human transglutaminase 2 in complex with adenosine triphosphate
Int.J.Biol.Macromol., 47, 2010
1EVU
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HUMAN FACTOR XIII WITH CALCIUM BOUND IN THE ION SITE
分子名称: CALCIUM ION, COAGULATION FACTOR XIII, S-1,2-PROPANEDIOL
著者Garzon, R.J, Pratt, K.P, Bishop, P.D, Le Trong, I, Stenkamp, R.E, Teller, D.C.
登録日2000-04-20
公開日2000-05-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Tryptophan 279 is Essential for the Transglutaminase Activity of Coagulation Factor XIII: Functional and Structural Characterization
To Be Published
1EX0
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HUMAN FACTOR XIII, MUTANT W279F ZYMOGEN
分子名称: CALCIUM ION, COAGULATION FACTOR XIII A CHAIN, PHOSPHATE ION, ...
著者Garzon, R.J, Pratt, K.P, Bishop, P.D, Le Trong, I, Stenkamp, R.E, Teller, D.C.
登録日2000-04-28
公開日2003-12-23
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Tryptophan 279 is Essential for the Transglutaminase Activity of Coagulation Factor XIII: Functional and Structural Characterization
To be Published
3S3S
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Transglutaminase 2 in complex with a novel inhibitor
分子名称: Protein-glutamine gamma-glutamyltransferase 2, SULFATE ION, peptide inhibitor
著者Lindemann, I, Heine, A, Klebe, G.
登録日2011-05-18
公開日2012-06-06
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Inhibitors of Transglutaminase 2: A therapeutic option in celiac disease
To be Published
3S3P
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Transglutaminase 2 in complex with a novel inhibitor
分子名称: Peptide inhibitor, Protein-glutamine gamma-glutamyltransferase 2, SULFATE ION
著者Lindemann, I, Heine, A, Klebe, G.
登録日2011-05-18
公開日2012-06-06
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Transglutaminase 2 in complex with a novel inhibitor
To be Published
3S3J
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Transglutaminase 2 in complex with a novel inhibitor
分子名称: GLYCEROL, Peptide inhibitor, Protein-glutamine gamma-glutamyltransferase 2, ...
著者Lindemann, I, Heine, A, Klebe, G.
登録日2011-05-18
公開日2012-06-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Inhibitors of Transglutaminase 2: A therapeutic option in celiac disease
To be Published
1KV3
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HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM
分子名称: GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase
著者Liu, S, Cerione, R.A, Clardy, J.
登録日2002-01-24
公開日2002-03-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
Proc.Natl.Acad.Sci.USA, 99, 2002
1L9M
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Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation
分子名称: BROMIDE ION, CALCIUM ION, CHLORIDE ION, ...
著者Ahvazi, B.
登録日2002-03-26
公開日2002-05-29
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.
EMBO J., 21, 2002
1L9N
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Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation
分子名称: 2-O-octyl-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Ahvazi, B.
登録日2002-03-26
公開日2002-05-29
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.
EMBO J., 21, 2002
5MHL
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FXIIIa in complex with the inhibitor Mi0621
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Coagulation factor XIII A chain, ...
著者Stieler, M, Heine, A, Klebe, G.
登録日2016-11-24
公開日2017-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献FXIIIa in complex with the inhibitor Mi0621
To Be Published
5MHM
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FXIIIa in complex with the inhibitor ZED1630
分子名称: CALCIUM ION, CHLORIDE ION, Coagulation factor XIII A chain, ...
著者Stieler, M, Heine, A, Klebe, G.
登録日2016-11-24
公開日2017-12-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献FXIIIa in complex with the inhibitor Mi0621
To Be Published
5MHO
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FXIIIa in complex with the inhibitor ZED2369
分子名称: CALCIUM ION, Coagulation factor XIII A chain, SULFATE ION, ...
著者Stieler, M, Heine, A, Klebe, G.
登録日2016-11-24
公開日2017-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献FXIIIa in complex with the inhibitor ZED2369
To Be Published
8CSW
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BU of 8csw by Molmil
Local refinement of protein 4.2 in Class 2 of erythrocyte ankyrin-1 complex
分子名称: Protein 4.2
著者Vallese, F, Kim, K, Yen, L.Y, Johnston, J.D, Noble, A.J, Cali, T, Clarke, O.B.
登録日2022-05-13
公開日2022-07-20
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Architecture of the human erythrocyte ankyrin-1 complex.
Nat.Struct.Mol.Biol., 29, 2022
8OXY
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BU of 8oxy by Molmil
Transglutaminase 3 without calcium in complex with DH patient-derived Fab DH63-B02
分子名称: 1,2-ETHANEDIOL, Antibody fab fragment heavy chain, Antibody fab fragment light chain, ...
著者Heggelund, J.E, Sollid, L.M.
登録日2023-05-02
公開日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.
Nat Commun, 14, 2023
8OXW
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Transglutaminase 3 in complex with DH patient-derived Fab DH63-B02
分子名称: 1,2-ETHANEDIOL, Antibody fab fragment heavy chain, Antibody fab fragment light chain, ...
著者Heggelund, J.E, Sollid, L.M.
登録日2023-05-02
公開日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.
Nat Commun, 14, 2023
8OXV
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Transglutaminase 3 zymogen in complex with DH patient-derived Fab DH63-B02
分子名称: 1,2-ETHANEDIOL, Antibody Fab fragment Heavy chain, Antibody Fab fragment light chain, ...
著者Heggelund, J.E, Sollid, L.M.
登録日2023-05-02
公開日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.
Nat Commun, 14, 2023
8OXX
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Transglutaminase 3 in complex with inhibitor Z-don and DH patient-derived Fab DH63-B02
分子名称: 1,2-ETHANEDIOL, 5-OXO-L-NORLEUCINE, Antibody fab fragment heavy chain, ...
著者Heggelund, J.E, Sollid, L.M.
登録日2023-05-02
公開日2023-10-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.
Nat Commun, 14, 2023
1NUF
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Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme
分子名称: BROMIDE ION, CALCIUM ION, CHLORIDE ION, ...
著者Ahvazi, B.
登録日2003-01-31
公開日2003-04-22
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Roles of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme
J.Biol.Chem., 278, 2003
5MHN
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FXIIIa in complex with the inhibitor ZED2360
分子名称: CALCIUM ION, Coagulation factor XIII A chain, GLYCEROL, ...
著者Stieler, M, Heine, A, Klebe, G.
登録日2016-11-24
公開日2017-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献FXIIIa in complex with the inhibitor Mi0621
To Be Published
1NUD
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Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (3 calciums, active form)
分子名称: BROMIDE ION, CALCIUM ION, CHLORIDE ION, ...
著者Ahvazi, B.
登録日2003-01-31
公開日2003-04-22
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Roles of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme
J.Biol.Chem., 278, 2003

 

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