8OXX
Transglutaminase 3 in complex with inhibitor Z-don and DH patient-derived Fab DH63-B02
Summary for 8OXX
| Entry DOI | 10.2210/pdb8oxx/pdb |
| Descriptor | Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain, D-PROLINE, METHYL L-LEUCINATE, ... (12 entities in total) |
| Functional Keywords | transglutaminase, tgm3, tg3, transglutaminase 3, enzyme, antibody, dermatitis herpetiformis, inhibitor, z-don, ighv3-9, iglv6-57, transferase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 99261.31 |
| Authors | Heggelund, J.E.,Sollid, L.M. (deposition date: 2023-05-02, release date: 2023-10-18, Last modification date: 2023-11-15) |
| Primary citation | Heggelund, J.E.,Das, S.,Stamnaes, J.,Iversen, R.,Sollid, L.M. Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3. Nat Commun, 14:6216-6216, 2023 Cited by PubMed: 37798283DOI: 10.1038/s41467-023-42004-z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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