8OXX

Transglutaminase 3 in complex with inhibitor Z-don and DH patient-derived Fab DH63-B02

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0018149	biological_process	peptide cross-linking

Functional Information from PROSITE/UniProt

site_id	PS00547
Number of Residues	18
Details	TRANSGLUTAMINASES Transglutaminases active site. GQCWVfAGTlnTaLRSLG

Chain	Residue	Details
A	GLY271-GLY288

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR203-HIS209
C	TYR195-HIS201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10024

Chain	Residue	Details
A	CYS273
A	HIS331
A	ASP354

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site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269|PubMed:11980702, ECO:0000269|PubMed:12679341

Chain	Residue	Details
A	ALA222
A	ASN225
A	ASN227
A	ASP228
A	ASN230
A	ASP302
A	ASP304
A	ASN306
A	SER308
A	ASP325
A	ASN394
A	SER416
A	GLU444
A	GLU449

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.7

Chain	Residue	Details
A	ALA2

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	TYR111

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	THR112

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