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PDB: 682 件
1BEZ
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BU of 1bez by Molmil
HALOALKANE DEHALOGENASE MUTANT WITH TRP 175 REPLACED BY TYR AT PH 5
分子名称: ACETIC ACID, HALOALKANE DEHALOGENASE
著者Ridder, I.S, Vos, G.J, Rozeboom, H.J, Kalk, K.H, Dijkstra, B.W.
登録日1998-05-18
公開日1998-11-11
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Kinetic analysis and X-ray structure of haloalkane dehalogenase with a modified halide-binding site.
Biochemistry, 37, 1998
5BOV
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BU of 5bov by Molmil
Crystal structure of a putative epoxide hydrolase (KPN_01808) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 1.60 A resolution
分子名称: Putative epoxide hydrolase protein
著者Joint Center for Structural Genomics (JCSG)
登録日2015-05-27
公開日2015-06-10
最終更新日2023-02-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of a putative epoxide hydrolase (KPN_01808) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 1.60 A resolution
To be published
5C8Z
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ZHD-ZGR complex after ZHD crystal soaking in ZEN for 30min
分子名称: 2,4-dihydroxy-6-[(1E,10S)-10-hydroxy-6-oxoundec-1-en-1-yl]benzoic acid, FORMIC ACID, GLYCEROL, ...
著者Hu, X.-J, Qi, Q, Yang, W.-J.
登録日2015-06-26
公開日2016-06-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The structure of a complex of the lactonohydrolase zearalenone hydrolase with the hydrolysis product of zearalenone at 1.60 angstrom resolution.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5C7Y
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BU of 5c7y by Molmil
ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 9min
分子名称: (1E,10S)-1-(3,5-dihydroxyphenyl)-10-hydroxyundec-1-en-6-one, FORMIC ACID, GLYCEROL, ...
著者Hu, X.-J, Qi, Q, Yang, W.-J.
登録日2015-06-25
公開日2016-06-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A Case Study of Lactonase ZHD
To Be Published
5C81
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BU of 5c81 by Molmil
ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 12min
分子名称: (1E,10S)-1-(3,5-dihydroxyphenyl)-10-hydroxyundec-1-en-6-one, FORMIC ACID, GLYCEROL, ...
著者Hu, X.-J, Qi, Q, Yang, W.-J.
登録日2015-06-25
公開日2016-06-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A Case Study of Lactonase ZHD
To Be Published
5CW2
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BU of 5cw2 by Molmil
Crystal structure of Epoxide Hydrolase A from Mycobacterium thermoresistibile
分子名称: 1,3-DIPHENYLUREA, Putative epoxide hydrolase EPHA, SODIUM ION
著者Schulz, E.C, Wilmanns, M.
登録日2015-07-27
公開日2016-08-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of mycobacterial Epoxide Hydrolase A
To Be Published
5D7B
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BU of 5d7b by Molmil
Trigonal Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum
分子名称: GLYCEROL, Homoserine O-acetyltransferase
著者Niefind, K, Toelzer, C, Pal, S, Altenbuchner, J, Watzlawick, H.
登録日2015-08-13
公開日2015-12-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.
Febs Lett., 590, 2016
5D6O
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Orthorhombic Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum
分子名称: CHLORIDE ION, GLYCEROL, Homoserine O-acetyltransferase, ...
著者Niefind, K, Toelzer, C, Altenbuchner, J, Watzlawick, H.
登録日2015-08-12
公開日2015-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.
Febs Lett., 590, 2016
5E4Y
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BU of 5e4y by Molmil
Orthorhombic structure of the acetyl esterase MekB
分子名称: Homoserine O-acetyltransferase
著者Niefind, K, Toelzer, C, Pal, S, Watzlawick, H, Altenbuchner, J.
登録日2015-10-07
公開日2015-12-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.
Febs Lett., 590, 2016
5BKM
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BU of 5bkm by Molmil
Crystal Structure of Hip1 (Rv2224c) mutant - S228DHA (dehydroalanine)
分子名称: Carboxylesterase A
著者Naffin-Olivos, J.L, Daab, A, Goldfarb, N.E, Doran, M.H, Baikovitz, J, Liu, D, Sun, S, White, A, Dunn, B.M, Rengarajan, J, Petsko, G.A, Ringe, D.
登録日2021-03-20
公開日2022-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.703 Å)
主引用文献Crystal Structure of Hip1 (Rv2224c) mutant - S228DHA (dehydroalanine)
To Be Published
5C8X
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ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 20min
分子名称: (1E,10S)-1-(3,5-dihydroxyphenyl)-10-hydroxyundec-1-en-6-one, GLYCEROL, POTASSIUM ION, ...
著者Hu, X.-J, Qi, Q, Yang, W.-J.
登録日2015-06-26
公開日2016-06-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A Case Study of Lactonase ZHD
To Be Published
3KOO
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BU of 3koo by Molmil
Crystal Structure of soluble epoxide Hydrolase
分子名称: Epoxide hydrolase 2, N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide
著者Farrow, N.A.
登録日2009-11-13
公開日2010-04-28
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.791 Å)
主引用文献Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase.
Bioorg.Med.Chem.Lett., 20, 2010
5FP0
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BU of 5fp0 by Molmil
ligand complex structure of soluble epoxide hydrolase
分子名称: BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, N-cyclopentyl-2-[4-(trifluoromethyl)phenyl]-3H-benzimidazole-4-sulfonamide
著者Xue, Y, Olsson, T, Johansson, C.A, Oster, L, Beisel, H.G, Rohman, M, Karis, D, Backstrom, S.
登録日2015-11-26
公開日2016-03-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration.
Chemmedchem, 11, 2016
8G5T
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BU of 8g5t by Molmil
Crystal structure of apo TnmK2
分子名称: TnmK2
著者Liu, Y.-C, Gui, C, Shen, B.
登録日2023-02-14
公開日2023-10-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.846 Å)
主引用文献Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis.
Nat.Chem.Biol., 20, 2024
8G5U
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BU of 8g5u by Molmil
Crystal structure of TnmK2 complexed with TNM B
分子名称: TnmK2, methyl (2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate
著者Liu, Y.-C, Gui, C, Shen, B.
登録日2023-02-14
公開日2023-10-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.804 Å)
主引用文献Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis.
Nat.Chem.Biol., 20, 2024
4QFF
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BU of 4qff by Molmil
Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, quadruple mutant, P212121 form
分子名称: Non-haem bromoperoxidase BPO-A2, Matrix protein 1 chimera
著者Lai, Y.-T, Yeates, T.O.
登録日2014-05-20
公開日2015-05-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (7.811 Å)
主引用文献Structural transition of a protein nanocage as a function of pH and salt concentration
To be Published
1ZD2
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BU of 1zd2 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-ethanoic acid complex
分子名称: MAGNESIUM ION, N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE, PHOSPHATE ION, ...
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2005-04-14
公開日2006-03-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
1ZD5
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BU of 1zd5 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-heptanoic acid complex
分子名称: 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2005-04-14
公開日2006-03-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
1ZD4
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BU of 1zd4 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-hexanoic acid complex
分子名称: 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2005-04-14
公開日2006-03-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
1ZD3
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BU of 1zd3 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-butyric acid complex
分子名称: 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2005-04-14
公開日2006-03-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
2ES4
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BU of 2es4 by Molmil
Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase
分子名称: CALCIUM ION, IODIDE ION, Lipase, ...
著者Pauwels, K, Wyns, L, Tommassen, J, Savvides, S.N, Van Gelder, P.
登録日2005-10-25
公開日2006-03-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of a membrane-based steric chaperone in complex with its lipase substrate.
Nat.Struct.Mol.Biol., 13, 2006
4OCZ
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BU of 4ocz by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
分子名称: 1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
著者Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morriseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D.
登録日2014-01-09
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J.Med.Chem., 57, 2014
6YNX
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BU of 6ynx by Molmil
Cryo-EM structure of Tetrahymena thermophila mitochondrial ATP synthase - Fo-subcomplex
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Kock Flygaard, R, Muhleip, A, Amunts, A.
登録日2020-04-14
公開日2020-09-30
最終更新日2020-11-11
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.
Nat Commun, 11, 2020
1S8O
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Human soluble Epoxide Hydrolase
分子名称: HEXAETHYLENE GLYCOL, epoxide hydrolase 2, cytoplasmic
著者Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
登録日2004-02-03
公開日2004-04-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
Biochemistry, 43, 2004
4OD0
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BU of 4od0 by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
分子名称: 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
著者Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morisseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D.
登録日2014-01-09
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J.Med.Chem., 57, 2014

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