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PDB: 93 件
6MW3
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EM structure of Bacillus subtilis ribonucleotide reductase inhibited filament composed of NrdE alpha subunit and NrdF beta subunit with dATP
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase, Ribonucleoside-diphosphate reductase NrdF beta subunit
著者Thomas, W.C, Bacik, J.P, Kaelber, J.T, Ando, N.
登録日2018-10-29
公開日2019-06-19
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.65 Å)
主引用文献Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
7RW6
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BORF2-APOBEC3Bctd Complex
分子名称: DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION
著者Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S.
登録日2021-08-19
公開日2022-04-27
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (2.55 Å)
主引用文献Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
Sci Adv, 8, 2022
7AGJ
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BU of 7agj by Molmil
Ribonucleotide Reductase R1 protein from Aquifex aeolicus
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Rehling, D, Scaletti, E.R, Stenmark, P.
登録日2020-09-22
公開日2021-10-06
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Biochemistry, 61, 2022
4X3V
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BU of 4x3v by Molmil
Crystal structure of human ribonucleotide reductase 1 bound to inhibitor
分子名称: N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine, Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE
著者Dealwis, C.G, Ahmad, M.F, Alam, I.
登録日2014-12-01
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.
J.Med.Chem., 58, 2015
7R1R
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BU of 7r1r by Molmil
RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
著者Eriksson, M, Eklund, H.
登録日1997-09-17
公開日1998-03-18
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
5D1Y
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BU of 5d1y by Molmil
Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP
分子名称: Ribonucleoside-diphosphate reductase large subunit
著者Ando, N, Li, H, Brignole, E.J, Thompson, S, McLaughlin, M.I, Page, J, Asturias, F, Stubbe, J, Drennan, C.L.
登録日2015-08-04
公開日2016-01-20
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (9.005 Å)
主引用文献Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.
Biochemistry, 55, 2016
6R1R
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RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
著者Eriksson, M, Eklund, H.
登録日1997-09-17
公開日1998-03-18
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
4R1R
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RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI
分子名称: GUANOSINE-5'-DIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, ...
著者Eriksson, M, Eklund, H.
登録日1997-07-22
公開日1998-01-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997
5IM3
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Crystal structure of the class I ribonucleotide reductase from Pseudomonas aeruginosa in complex with dATP
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase
著者Johansson, R, Logan, D.T.
登録日2016-03-05
公開日2016-05-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones.
Structure, 24, 2016
6AUI
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BU of 6aui by Molmil
Human ribonucleotide reductase large subunit (alpha) with dATP and CDP
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A.
登録日2017-09-01
公開日2018-04-18
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.
Elife, 7, 2018
1R1R
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BU of 1r1r by Molmil
RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI
分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
著者Eriksson, M, Eklund, H.
登録日1997-07-15
公開日1998-01-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997
5R1R
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RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
著者Eriksson, M, Eklund, H.
登録日1997-09-17
公開日1998-03-18
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
1RLR
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BU of 1rlr by Molmil
STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1
分子名称: RIBONUCLEOTIDE REDUCTASE PROTEIN R1
著者Uhlin, U, Eklund, H.
登録日1994-08-12
公開日1996-12-23
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of ribonucleotide reductase protein R1.
Nature, 370, 1994
5TUS
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BU of 5tus by Molmil
Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule
分子名称: 2-hydroxy-N'-[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ...
著者Mohammed, F.A, Alam, I, Dealwis, C.G.
登録日2016-11-07
公開日2017-08-02
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6MT9
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BU of 6mt9 by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N.
登録日2018-10-19
公開日2019-06-19
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6CGL
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BU of 6cgl by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound as-isolated (pH 4)
分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Ribonucleoside-diphosphate reductase, SULFATE ION
著者Maggiolo, A.O, Boal, A.K.
登録日2018-02-20
公開日2018-05-09
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MVE
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BU of 6mve by Molmil
Reduced X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N.
登録日2018-10-25
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6CGN
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X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound (pH 7)
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ...
著者Maggiolo, A.O, Boal, A.K.
登録日2018-02-20
公開日2018-05-09
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MYX
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BU of 6myx by Molmil
EM structure of Bacillus subtilis ribonucleotide reductase inhibited double-helical filament of NrdE alpha subunit with dATP
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Ribonucleoside-diphosphate reductase
著者Thomas, W.C, Bacik, J.P, Chen, J.Z, Ando, N.
登録日2018-11-02
公開日2019-06-19
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (6 Å)
主引用文献Convergent allostery in ribonucleotide reductase.
Nat Commun, 10, 2019
6CGM
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BU of 6cgm by Molmil
X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit (nucleotide free)
分子名称: 1,2-ETHANEDIOL, Ribonucleoside-diphosphate reductase
著者Maggiolo, A.O, Boal, A.K.
登録日2018-02-20
公開日2018-05-09
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2ZLF
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BU of 2zlf by Molmil
The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase
分子名称: FTLDADF, Ribonucleoside-diphosphate reductase large chain 1
著者Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C.
登録日2008-04-09
公開日2008-08-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
3O0Q
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Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosine
分子名称: ADENOSINE, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Larsson, K.-M, Logan, D.T, Nordlund, P.
登録日2010-07-19
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases.
Acs Chem.Biol., 5, 2010
3O0O
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Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosylcobalamin
分子名称: 5'-DEOXYADENOSINE, COBALAMIN, GUANOSINE-5'-DIPHOSPHATE, ...
著者Larsson, K.-M, Logan, D.T, Nordlund, P.
登録日2010-07-19
公開日2010-07-28
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases.
Acs Chem.Biol., 5, 2010
2XO4
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RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI
分子名称: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
著者Minnihan, E.C, Seyedsayamdost, M.R, Uhlin, U, Stubbe, J.
登録日2010-08-09
公開日2010-08-18
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases.
J.Am.Chem.Soc., 133, 2011
6L3R
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Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide
分子名称: 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide, ACETATE ION, MAGNESIUM ION, ...
著者Miyahara, S, Chong, K.T, Suzuki, T.
登録日2019-10-15
公開日2020-10-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published

 

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