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PDB: 588 件
6P5R
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BU of 6p5r by Molmil
Structure of T. brucei MERS1-GDP complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, Mitochondrial edited mRNA stability factor 1
著者Schumacher, M.A.
登録日2019-05-30
公開日2019-11-06
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei.
Rna, 26, 2020
6PCL
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BU of 6pcl by Molmil
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 5-IP7
分子名称: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ...
著者Dollins, D.E, Neubauer, J, Dong, J, York, J.D.
登録日2019-06-17
公開日2020-04-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.
Proc.Natl.Acad.Sci.USA, 117, 2020
7ESF
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BU of 7esf by Molmil
The Crystal Structure of human MTH1 from Biortus
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL
著者Wang, F, Cheng, W, Shang, H, Wang, R, Zhang, B, Tian, F.
登録日2021-05-10
公開日2021-05-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The Crystal Structure of human MTH1 from Biortus
To Be Published
5U7H
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BU of 5u7h by Molmil
Ni-bound dihydroneopterin triphosphate pyrophosphohydrolase from E. coli
分子名称: Dihydroneopterin triphosphate diphosphatase, NICKEL (II) ION, SULFATE ION
著者Nguyen, E, Hill, S.E, Lieberman, R.L.
登録日2016-12-12
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism.
PLoS ONE, 12, 2017
5U7F
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BU of 5u7f by Molmil
Co-bound dihydroneopterin triphosphate pyrophosphohydrolase from E. coli
分子名称: COBALT (II) ION, Dihydroneopterin triphosphate diphosphatase, SULFATE ION
著者Nguyen, E, Hill, S.E, Lieberman, R.L.
登録日2016-12-12
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.789 Å)
主引用文献Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism.
PLoS ONE, 12, 2017
7NR6
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BU of 7nr6 by Molmil
Structure of NUDT15 in complex with NSC56456
分子名称: 1,2-ETHANEDIOL, 2-azanyl-9-cyclohexyl-3~{H}-purine-6-thione, MAGNESIUM ION, ...
著者Rehling, D, Stenmark, P.
登録日2021-03-03
公開日2022-03-23
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Coupling cellular target engagement to drug-induced responses with CeTEAM
To Be Published
5T3P
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BU of 5t3p by Molmil
Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7
分子名称: 1,2-ETHANEDIOL, Peroxisomal coenzyme A diphosphatase NUDT7
著者Srikannathasan, V, Nunez, C.A, Tallant, C, Siejka, P, Mathea, S, Kopec, J, Elkins, J.M, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Huber, K.
登録日2016-08-26
公開日2017-09-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7
To Be Published
4S2W
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BU of 4s2w by Molmil
Structure of E. coli RppH bound to sulfate ions
分子名称: RNA pyrophosphohydrolase, SULFATE ION
著者Vasilyev, N, Serganov, A.
登録日2015-01-23
公開日2015-02-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.992 Å)
主引用文献Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5'-End-dependent mRNA Decay.
J.Biol.Chem., 290, 2015
5U7E
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BU of 5u7e by Molmil
Apo dihydroneopterin triphosphate pyrophosphohydrolase from E. coli
分子名称: Dihydroneopterin triphosphate diphosphatase, GLYCEROL, SULFATE ION
著者Nguyen, E, Hill, S.E, Lieberman, R.L.
登録日2016-12-12
公開日2017-06-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.942 Å)
主引用文献Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism.
PLoS ONE, 12, 2017
7DNU
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BU of 7dnu by Molmil
mRNA-decapping enzyme g5Rp with inhibitor insp6 complex
分子名称: INOSITOL HEXAKISPHOSPHATE, mRNA-decapping protein g5R
著者Yang, Y, Chen, C, Li, L, Li, X.H, Su, D.
登録日2020-12-10
公開日2021-12-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.245 Å)
主引用文献Structural Insight into Molecular Inhibitory Mechanism of InsP 6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp.
J.Virol., 96, 2022
4S2X
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BU of 4s2x by Molmil
Structure of E. coli RppH bound to RNA and two magnesium ions
分子名称: MAGNESIUM ION, RNA (5'-R(*(APC)*GP*U)-3'), RNA pyrophosphohydrolase, ...
著者Vasilyev, N, Serganov, A.
登録日2015-01-23
公開日2015-02-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5'-End-dependent mRNA Decay.
J.Biol.Chem., 290, 2015
7DNT
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BU of 7dnt by Molmil
mRNA-decapping enzyme g5Rp
分子名称: mRNA-decapping protein g5R
著者Yang, Y, Chen, C, Li, L, Li, X.H, Su, D.
登録日2020-12-10
公開日2022-03-09
最終更新日2022-12-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Insight into Molecular Inhibitory Mechanism of InsP 6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp.
J.Virol., 96, 2022
4S2Y
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BU of 4s2y by Molmil
Structure of E. coli RppH bound to RNA and three magnesium ions
分子名称: CHLORIDE ION, MAGNESIUM ION, RNA (5'-R(*(APC)*GP*U)-3'), ...
著者Vasilyev, N, Serganov, A.
登録日2015-01-23
公開日2015-02-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5'-End-dependent mRNA Decay.
J.Biol.Chem., 290, 2015
4S2V
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BU of 4s2v by Molmil
E. coli RppH structure, KI soak
分子名称: ACETATE ION, CALCIUM ION, IODIDE ION, ...
著者Vasilyev, N, Serganov, A.
登録日2015-01-23
公開日2015-02-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5'-End-dependent mRNA Decay.
J.Biol.Chem., 290, 2015
6JVO
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BU of 6jvo by Molmil
Crystal structure of human MTH1 in complex with compound MI1022
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, N4-cyclopropyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
著者Peng, C, Li, Y.H, Cheng, Y.S.
登録日2019-04-17
公開日2020-10-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.902 Å)
主引用文献Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Bioorg.Chem., 110, 2021
6JVH
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BU of 6jvh by Molmil
Crystal structure of human MTH1 in complex with compound MI0320
分子名称: 4-amino-6-fluoroquinoline-3-carbohydrazide, 7,8-dihydro-8-oxoguanine triphosphatase
著者Peng, C, Cheng, Y.S.
登録日2019-04-17
公開日2020-10-28
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Bioorg.Chem., 110, 2021
6JVM
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BU of 6jvm by Molmil
Crystal structure of human MTH1 in complex with compound MI1016
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, N4-cyclopropyl-5-ethyl-6-piperidin-1-yl-pyrimidine-2,4-diamine
著者Peng, C, Li, Y.H, Cheng, Y.S.
登録日2019-04-17
公開日2020-10-28
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.098 Å)
主引用文献Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Bioorg.Chem., 110, 2021
2G74
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BU of 2g74 by Molmil
Y104F mutant of type 1 isopentenylpyrophosphate-dimethylallylpyrophosphate isomerase
分子名称: Isopentenyl-diphosphate delta-isomerase, MAGNESIUM ION, MANGANESE (II) ION
著者de Ruyck, J, Wouters, J.
登録日2006-02-27
公開日2006-04-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography.
J.Biol.Chem., 281, 2006
2FVV
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BU of 2fvv by Molmil
Human Diphosphoinositol polyphosphate phosphohydrolase 1
分子名称: CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, INOSITOL HEXAKISPHOSPHATE, ...
著者Hallberg, B.M, Kursula, P, Ogg, D, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Graslund, S, Hammarstrom, M, Hogbom, M, Holmberg-Schiavone, L, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Persson, C, Structural Genomics Consortium (SGC)
登録日2006-01-31
公開日2006-03-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Crystal structure of human diphosphoinositol phosphatase 1
Proteins, 77, 2009
6JVF
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BU of 6jvf by Molmil
Crystal structure of human apo MTH1
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase
著者Peng, C, Cheng, Y.S.
登録日2019-04-17
公開日2020-10-28
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Bioorg.Chem., 110, 2021
6JVL
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BU of 6jvl by Molmil
Crystal structure of human MTH1 in complex with compound MI1014
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, N4-cyclopropyl-5-ethyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
著者Peng, C, Li, Y.H, Cheng, Y.S.
登録日2019-04-17
公開日2020-10-28
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Bioorg.Chem., 110, 2021
2G73
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BU of 2g73 by Molmil
Y104F mutant type 1 IPP isomerase complex with EIPP
分子名称: 4-HYDROXY-3-METHYL BUTYL DIPHOSPHATE, Isopentenyl-diphosphate delta-isomerase, MAGNESIUM ION, ...
著者de Ruyck, J, Wouters, J.
登録日2006-02-27
公開日2006-04-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography.
J.Biol.Chem., 281, 2006
4HVY
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BU of 4hvy by Molmil
A thermostable variant of human NUDT18 NUDIX domain obtained by Hot Colony Filtration
分子名称: GLYCEROL, MAGNESIUM ION, Nucleoside diphosphate-linked moiety X motif 18, ...
著者Asial, I, Cheng, Y.X, Engman, H, Wu, B, Dollhopf, M, Nordlund, P, Cornvik, T.
登録日2012-11-07
公開日2014-01-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell.
Nat Commun, 4, 2013
8A0S
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BU of 8a0s by Molmil
MTH1 in complex with TH013350
分子名称: 4-[(2-chlorophenyl)methylsulfanyl]-5~{H}-pyrimidin-2-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Liu, H, Scaletti, E, Stenmark, P.
登録日2022-05-30
公開日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献MTH1 in complex with TH013350
To Be Published
8A3A
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MTH1 in complex with TH013074
分子名称: 4-(4-methylphenyl)-1~{H}-quinazolin-2-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Liu, H, Scaletti, E, Stenmark, P.
登録日2022-06-07
公開日2023-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献MTH1 in complex with TH013074
To Be Published

222415

件を2024-07-10に公開中

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