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PDB: 616 件
4Y3B
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Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma
分子名称: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C
著者Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C.
登録日2015-02-10
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
4Y32
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BU of 4y32 by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma
分子名称: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC
著者Bartel, M, Milroy, L, Bier, D, Brunsveld, L, Ottmann, C.
登録日2015-02-10
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
5OM0
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BU of 5om0 by Molmil
CH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide around Ser640
分子名称: 14-3-3 protein sigma,Zinc finger protein GLI1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION
著者Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A.
登録日2017-07-28
公開日2017-10-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners.
Sci Rep, 7, 2017
1O9C
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BU of 1o9c by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
分子名称: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION
著者Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
登録日2002-12-12
公開日2003-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
5NWJ
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BU of 5nwj by Molmil
14-3-3c in complex with CPP7
分子名称: 14-3-3-like protein C, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
著者Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A.
登録日2017-05-06
公開日2017-11-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.
Plant Cell, 29, 2017
1O9F
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BU of 1o9f by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
分子名称: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE
著者Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
登録日2002-12-12
公開日2003-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9E
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BU of 1o9e by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
分子名称: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN
著者Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
登録日2002-12-12
公開日2003-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
4WRQ
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Crystal Structure of 14-3-3 zeta with Chibby peptide
分子名称: 14-3-3 protein zeta/delta, Chibby
著者Killoran, R.C, Shilton, B.H, Choy, W.Y.
登録日2014-10-24
公開日2015-05-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.409 Å)
主引用文献Structural Analysis of the 14-3-3 zeta /Chibby Interaction Involved in Wnt/ beta-Catenin Signaling.
Plos One, 10, 2015
1O9D
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BU of 1o9d by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
分子名称: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE
著者Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
登録日2002-12-12
公開日2003-03-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
5OK9
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CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with swapped phosphopeptides
分子名称: 14-3-3 protein sigma,Heat shock protein beta-6, DI(HYDROXYETHYL)ETHER
著者Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A.
登録日2017-07-25
公開日2017-10-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners.
Sci Rep, 7, 2017
5OEH
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BU of 5oeh by Molmil
Molecular tweezers modulate 14-3-3 protein-protein interactions.
分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION, ...
著者Bier, D, Ottmann, C.
登録日2017-07-07
公開日2017-07-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Molecular tweezers modulate 14-3-3 protein-protein interactions.
Nat Chem, 5, 2013
5OKF
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CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with self-bound phosphopeptides
分子名称: 14-3-3 protein sigma,Heat shock protein beta-6, CADMIUM ION
著者Sluchanko, N.N, Tugaeva, K.V, Greive, S.J, Antson, A.A.
登録日2017-07-25
公開日2017-10-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners.
Sci Rep, 7, 2017
4ZDR
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BU of 4zdr by Molmil
Crystal structure of 14-3-3[zeta]-LKB1 fusion protein
分子名称: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ...
著者Ding, S, Shi, Z.B.
登録日2015-04-18
公開日2015-09-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.899 Å)
主引用文献Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3.
Acta Crystallogr.,Sect.F, 71, 2015
4Y5I
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BU of 4y5i by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 126B with 14-3-3sigma
分子名称: 14-3-3 protein sigma, CHLORIDE ION, Microtubule-associated protein tau
著者Leysen, S, Bartel, M, Milroy, L, Brunsveld, L, Ottmann, C.
登録日2015-02-11
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
4ZQ0
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BU of 4zq0 by Molmil
crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap
分子名称: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION
著者Fiorillo, A, Ilari, A.
登録日2015-05-08
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions.
J.Chem.Inf.Model., 55, 2015
1QJB
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BU of 1qjb by Molmil
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
分子名称: 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE
著者Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B.
登録日1999-06-23
公開日1999-09-15
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1QJA
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BU of 1qja by Molmil
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
分子名称: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
著者Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B.
登録日1999-06-23
公開日1999-09-15
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
6HMU
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BU of 6hmu by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C45 mutant bound to disulfide fragment PPI stabilizer 6
分子名称: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(3-sulfanylpropyl)propanamide, Estrogen receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-12
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HN2
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BU of 6hn2 by Molmil
Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 5
分子名称: 14-3-3 protein sigma, 2-(3,4-dichlorophenyl)-~{N}-(2-sulfanylethyl)ethanamide, Estrogen Receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-13
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HKB
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Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 3
分子名称: (1~{R},2~{S})-2-[methyl-[(~{R})-(2-methylpropan-2-yl)oxy-oxidanyl-methyl]amino]-2-phenyl-1-(2-sulfanylethylamino)ethanol, 14-3-3 protein sigma, Estrogen receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-06
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HEP
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BU of 6hep by Molmil
Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768
分子名称: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator
著者Stevers, L.M, Ottmann, C, Brunsveld, L.
登録日2018-08-20
公開日2018-10-24
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions.
J. Am. Chem. Soc., 140, 2018
6HHP
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Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 1
分子名称: (1~{R})-2-(4-chloranylphenoxy)-2-methyl-1-[methyl(2-sulfanylethyl)amino]propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-08-28
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HKF
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Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 4
分子名称: (1~{S})-2,2-diphenyl-1-(2-sulfanylethylamino)propan-1-ol, 14-3-3 protein sigma, Estrogen receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-06
公開日2019-02-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
6HMT
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Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment PPI stabilizer 2
分子名称: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen Receptor, ...
著者Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C.
登録日2018-09-12
公開日2019-02-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
J. Am. Chem. Soc., 141, 2019
8P1H
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Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor
分子名称: 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ...
著者Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N.
登録日2023-05-12
公開日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein.
Biochem.Biophys.Res.Commun., 682, 2023

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件を2024-08-14に公開中

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