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PDB: 244 件
2UZR
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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K)
分子名称: RAC-alpha serine/threonine-protein kinase
著者Carpten, J.D, Faber, A.L, Horn, C, Donoho, G.P, Briggs, S.L, Robbins, C.M, Hostetter, G, Boguslawski, S, Moses, T.Y, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, Y.W, Zeckner, D.J, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, M.H, Blanchard, K.L, Thomas, J.E.
登録日2007-05-01
公開日2007-07-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
Nature, 448, 2007
3RCP
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Crystal structure of the FAPP1 pleckstrin homology domain
分子名称: GLYCEROL, Pleckstrin homology domain-containing family A member 3
著者Roy, S, He, J, Kutateladze, T.G.
登録日2011-03-31
公開日2011-04-20
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain.
J.Biol.Chem., 286, 2011
2UVM
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Structure of PKBalpha PH domain in complex with a novel inositol headgroup surrogate, benzene 1,2,3,4-tetrakisphosphate
分子名称: BENZENE-1,2,3,4-TETRAYL TETRAKIS[DIHYDROGEN (PHOSPHATE)], RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE, SODIUM ION
著者Komander, D, Mills, S.J, Trusselle, M.N, Safrany, S.T, van Aalten, D.M.F, Potter, B.V.L.
登録日2007-03-12
公開日2007-04-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Novel Inositol Phospholipid Headgroup Surrogate Crystallised in the Pleckstrin Homology Domain of Protein Kinase Balpha.
Acs Chem.Biol., 2, 2007
2UZS
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BU of 2uzs by Molmil
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K)
分子名称: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, RAC-alpha serine/threonine-protein kinase
著者Carpten, J.D, Faber, A.L, Horn, C, Donoho, G.P, Briggs, S.L, Robbins, C.M, Hostetter, G, Boguslawski, S, Moses, T.Y, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, Y.W, Zeckner, D.J, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, M.H, Blanchard, K.L, Thomas, J.E.
登録日2007-05-01
公開日2007-07-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
Nature, 448, 2007
2X18
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The crystal structure of the PH domain of human AKT3 protein kinase
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
著者Vollmar, M, Wang, J, Zhang, Y, Elkins, J.M, Burgess-Brown, N, Chaikuad, A, Pike, A.C.W, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S.
登録日2009-12-22
公開日2010-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献The Crystal Structure of the Ph Domain of Human Akt3 Protein Kinase
To be Published
3TFM
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Myosin X PH1N-PH2-PH1C tandem
分子名称: Myosin X, PHOSPHATE ION
著者Yu, J, Lu, Q, Yan, J, Wei, Z, Zhang, M.
登録日2011-08-16
公開日2011-12-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor
MOLECULAR BIOLOGY OF THE CELL, 22, 2011
1X05
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Solution structure of the C-terminal PH domain of human pleckstrin
分子名称: Pleckstrin
著者Li, H, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-03-15
公開日2005-09-15
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the C-terminal PH domain of human pleckstrin
To be Published
1X1G
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Solution structure of the C-terminal PH domain of human pleckstrin 2
分子名称: Pleckstrin 2
著者Li, H, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-04-04
公開日2005-10-04
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the C-terminal PH domain of human pleckstrin 2
To be Published
3VIA
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Crystal structure of the PH domain of Evectin-2 from human
分子名称: Pleckstrin homology domain-containing family B member 2
著者Okazaki, S, Kato, R, Wakatsuki, S.
登録日2011-09-26
公開日2012-01-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis of the strict phospholipid binding specificity of the pleckstrin homology domain of human evectin-2
Acta Crystallogr.,Sect.D, 68, 2012
1WG7
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BU of 1wg7 by Molmil
Solution structure of pleckstrin homology domain from human KIAA1058 protein
分子名称: Dedicator of cytokinesis protein 9
著者Suetake, T, Inoue, K, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-05-27
公開日2004-11-27
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of pleckstrin homology domain from human KIAA1058 protein
to be published
1WI1
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Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)
分子名称: calcium-dependent activator protein for secretion, CAPS
著者Yoneyama, M, Izumi, K, Yoshida, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-05-28
公開日2004-11-28
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)
To be Published
2MDX
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BU of 2mdx by Molmil
Solution structure of the human wild type FAPP1-PH domain
分子名称: Pleckstrin homology domain-containing family A member 3
著者Lenoir, M, Overduin, M.
登録日2013-09-19
公開日2014-09-24
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure of the human wild type FAPP1-PH domain
To be Published
1X1F
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BU of 1x1f by Molmil
Solution structure of the PH domain of human Docking protein BRDG1
分子名称: Signal-transducing adaptor protein 1
著者Li, H, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-04-04
公開日2005-10-04
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the PH domain of human Docking protein BRDG1
To be Published
1WGQ
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BU of 1wgq by Molmil
Solution Structure of the Pleckstrin Homology Domain of Mouse Ethanol Decreased 4 Protein
分子名称: FYVE, RhoGEF and PH domain containing 6; ethanol decreased 4
著者Li, H, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-05-28
公開日2004-11-28
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution Structure of the Pleckstrin Homology Domain of Mouse Ethanol Decreased 4 Protein
To be Published
2P0D
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BU of 2p0d by Molmil
ArhGAP9 PH domain in complex with Ins(1,4,5)P3
分子名称: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Rho GTPase-activating protein 9
著者Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F.
登録日2007-02-28
公開日2007-03-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.811 Å)
主引用文献Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9.
J.Biol.Chem., 282, 2007
2P0F
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ArhGAP9 PH domain in complex with Ins(1,3,5)P3
分子名称: PHOSPHATE ION, Rho GTPase-activating protein 9
著者Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F.
登録日2007-02-28
公開日2007-03-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9.
J.Biol.Chem., 282, 2007
1ZM0
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Crystal Structure of the Carboxyl Terminal PH Domain of Pleckstrin To 2.1 Angstroms
分子名称: Pleckstrin
著者Jackson, S.G, Zhang, Y, Zhang, K, Summerfield, R, Haslam, R.J, Junop, M.S.
登録日2005-05-09
公開日2006-02-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the carboxy-terminal PH domain of pleckstrin at 2.1 Angstroms.
Acta Crystallogr.,Sect.D, 62, 2006
1XX0
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Structure of the C-terminal PH domain of human pleckstrin
分子名称: Pleckstrin
著者Edlich, C, Stier, G, Simon, B, Sattler, M, Muhle-Goll, C.
登録日2004-11-03
公開日2005-05-03
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin
STRUCTURE, 13, 2005
4A6F
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Crystal structure of Slm1-PH domain in complex with Phosphoserine
分子名称: PHOSPHATE ION, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1, PHOSPHOSERINE
著者Anand, K, Maeda, K, Gavin, A.C.
登録日2011-11-02
公開日2012-06-13
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Structural Analyses of Slm1-Ph Domain Demonstrate Ligand Binding in the Non-Canonical Site
Plos One, 7, 2012
2P0H
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ArhGAP9 PH domain in complex with Ins(1,3,4)P3
分子名称: (1S,3S,4S)-1,3,4-TRIPHOSPHO-MYO-INOSITOL, Rho GTPase-activating protein 9
著者Ceccarelli, D.F.J, Blasutig, I, Goudreault, M, Ruston, J, Pawson, T, Sicheri, F.
登録日2007-02-28
公開日2007-03-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9.
J.Biol.Chem., 282, 2007
4A5K
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Structural analyses of Slm1-PH domain demonstrate ligand binding in the non-canonical site
分子名称: PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM 1, SULFATE ION
著者Anand, K, Gavin, A.C.
登録日2011-10-25
公開日2012-06-13
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structural Analyses of Slm1-Ph Domain Demonstrate Ligand Binding in the Non-Canonical Site
Plos One, 7, 2012
2OTX
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Crystal Structure of A N-terminal Fragment of SKAP-HOM Containing both the Helical Dimerization Domain and the PH Domain
分子名称: Src kinase-associated phosphoprotein 2
著者Tang, Y, Swanson, K.D, Neel, B.G, Eck, M.J.
登録日2007-02-09
公開日2007-03-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
Mol.Cell, 32, 2008
4A6K
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Crystal structure of Slm1-PH domain in complex with D-myo-Inositol-4- phosphate
分子名称: D-MYO-INOSITOL-4-PHOSPHATE, PHOSPHATE ION, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1
著者Anand, K, Maeda, K, Gavin, A.C.
登録日2011-11-04
公開日2012-06-13
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Analyses of Slm1-Ph Domain Demonstrate Ligand Binding in the Non-Canonical Site
Plos One, 7, 2012
4A6H
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Crystal structure of Slm1-PH domain in complex with Inositol-4- phosphate
分子名称: D-MYO-INOSITOL-4-PHOSPHATE, PHOSPHATE ION, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1
著者Anand, K, Maeda, K, Gavin, A.C.
登録日2011-11-03
公開日2012-06-13
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.449 Å)
主引用文献Structural Analyses of Slm1-Ph Domain Demonstrate Ligand Binding in the Non-Canonical Site
Plos One, 7, 2012
1FHX
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Structure of the pleckstrin homology domain from GRP1 in complex with inositol 1,3,4,5-tetrakisphosphate
分子名称: GUANINE NUCLEOTIDE EXCHANGE FACTOR AND INTEGRIN BINDING PROTEIN HOMOLOG GRP1, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, SULFATE ION
著者Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A.
登録日2000-08-02
公開日2000-08-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains
Mol.Cell, 6, 2000

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