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PDB: 119 件
1E24
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LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM complexed with lysine and ATP and MN2+
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, LYSINE, ...
著者Desogus, G, Todone, F, Brick, P, Onesti, S.
登録日2000-05-16
公開日2000-07-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction
Biochemistry, 39, 2000
1EOV
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FREE ASPARTYL-TRNA SYNTHETASE (ASPRS) (E.C. 6.1.1.12) FROM YEAST
分子名称: ASPARTYL-TRNA SYNTHETASE
著者Sauter, C, Lorber, B, Cavarelli, J, Moras, D, Giege, R.
登録日2000-03-24
公開日2000-09-24
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The free yeast aspartyl-tRNA synthetase differs from the tRNA(Asp)-complexed enzyme by structural changes in the catalytic site, hinge region, and anticodon-binding domain.
J.Mol.Biol., 299, 2000
1EFW
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Crystal structure of aspartyl-tRNA synthetase from Thermus thermophilus complexed to tRNAasp from Escherichia coli
分子名称: ASPARTYL-TRNA, ASPARTYL-TRNA SYNTHETASE
著者Briand, C, Poterszman, A, Eiler, S, Webster, G, Thierry, J.-C, Moras, D.
登録日2000-02-10
公開日2000-06-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献An intermediate step in the recognition of tRNA(Asp) by aspartyl-tRNA synthetase.
J.Mol.Biol., 299, 2000
1EQR
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CRYSTAL STRUCTURE OF FREE ASPARTYL-TRNA SYNTHETASE FROM ESCHERICHIA COLI
分子名称: ASPARTYL-TRNA SYNTHETASE, MAGNESIUM ION
著者Rees, B, Webster, G, Delarue, M, Boeglin, M, Moras, D.
登録日2000-04-06
公開日2000-06-29
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Aspartyl tRNA-synthetase from Escherichia coli: flexibility and adaptability to the substrates.
J.Mol.Biol., 299, 2000
6ILH
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Crystal Structure of human lysyl-tRNA synthetase L350H mutant
分子名称: 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Lysine-tRNA ligase
著者Hei, Z, Liu, Z, Wang, J, Fang, P.
登録日2018-10-18
公開日2019-02-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
J. Biol. Chem., 294, 2019
6HHV
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Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)N3-methyluridine
分子名称: 5'-O-(N-(L-aspartyl)-sulfamoyl)N3-methyluridine, Aspartate--tRNA(Asp) ligase
著者De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D.
登録日2018-08-29
公開日2019-12-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HHX
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Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)cytidine
分子名称: 5'-O-(N-(L-aspartyl)-sulfamoyl)cytidine, Aspartate--tRNA(Asp) ligase
著者De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D.
登録日2018-08-29
公開日2019-12-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6HCW
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Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and a difluoro cyclohexyl chromone ligand
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LYSINE, Lysine--tRNA ligase, ...
著者Robinson, D.A, Baragana, B, Norcross, N, Forte, B, Walpole, C, Gilbert, I.H.
登録日2018-08-16
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc.Natl.Acad.Sci.USA, 116, 2019
6HCV
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Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with a chromone ligand
分子名称: 6-fluoranyl-~{N}-[(1-oxidanylcyclohexyl)methyl]-4-oxidanylidene-chromene-2-carboxamide, Lysine--tRNA ligase
著者Robinson, D.A, Baragana, B, Norcross, N, Forte, B, Walpole, C, Gilbert, I.H.
登録日2018-08-16
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc.Natl.Acad.Sci.USA, 116, 2019
6HHW
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Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)uridine
分子名称: 5'-O-(N-(L-aspartyl)-sulfamoyl)uridine, Aspartate--tRNA(Asp) ligase
著者De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D.
登録日2018-08-29
公開日2019-12-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6ILD
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Crystal Structure of Human LysRS: P38/AIMP2 Complex II
分子名称: 5'-O-[(S)-hydroxy(methyl)phosphoryl]adenosine, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, GLYCEROL, ...
著者Hei, Z, Liu, Z, Wang, J, Fang, P.
登録日2018-10-17
公開日2019-02-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.882 Å)
主引用文献Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
J. Biol. Chem., 294, 2019
6KA6
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Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1
分子名称: (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, GLYCEROL, LYSINE, ...
著者Zhou, J, Fang, P.
登録日2019-06-21
公開日2020-04-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.891 Å)
主引用文献Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
6KCN
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Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4
分子名称: 3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)isochromen-1-one, GLYCEROL, LYSINE, ...
著者Zhou, J, Fang, P.
登録日2019-06-28
公開日2020-04-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
6KCT
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Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 5
分子名称: 3-(cyclohexylmethyl)-6,8-bis(oxidanyl)isochromen-1-one, LYSINE, Lysine--tRNA ligase
著者Zhou, J, Fang, P.
登録日2019-06-29
公開日2020-04-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
6KBF
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Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3
分子名称: (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydro-2~{H}-isoquinolin-1-one, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Zhou, J, Fang, P.
登録日2019-06-24
公開日2020-04-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
6KAB
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Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 2
分子名称: (3~{S})-3-(cyclohexylmethyl)-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase
著者Zhou, J, Fang, P.
登録日2019-06-21
公開日2020-04-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.892 Å)
主引用文献Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
6HCU
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Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum bound to a difluoro cyclohexyl chromone ligand
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, HISTIDINE, ...
著者Tamjar, J, Robinson, D.A, Baragana, B, Norcross, N, Forte, B, Walpole, C, Gilbert, I.H.
登録日2018-08-16
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc.Natl.Acad.Sci.USA, 116, 2019
5Y6L
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A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric glutathione transferase-homology domains in multi-tRNA synthetase complex
分子名称: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Aspartate--tRNA ligase, cytoplasmic, ...
著者Cho, H.Y, Lee, H.J, Kang, B.S.
登録日2017-08-12
公開日2018-08-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric glutathione transferase-homology domains in multi-tRNA synthetase complex
To be published
6IY6
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Crystal structure of human cytosolic aspartyl-tRNA synthetase (DRS) in complex with glutathion-S transferase (GST) domains from Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) and glutamyl-prolyl-tRNA synthetase (EPRS)
分子名称: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Aspartate--tRNA ligase, cytoplasmic, ...
著者Park, S.H, Hahn, H, Han, B.W.
登録日2018-12-13
公開日2019-09-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献The DRS-AIMP2-EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex.
Iucrj, 6, 2019

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件を2024-07-17に公開中

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