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PDB: 176 件
4UBV
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Structure of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis with an partially acetylated cysteine in complex with acetyl-CoA and CoA
分子名称: 1,4-DIETHYLENE DIOXIDE, ACETYL COENZYME *A, Acetyl-CoA acetyltransferase FadA5, ...
著者Schaefer, C.M, Kisker, C.
登録日2014-08-13
公開日2014-12-17
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis.
Structure, 23, 2015
7YVY
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BU of 7yvy by Molmil
Crystal structure of thiolase PFC_04095 from Pyrococcus furiosus
分子名称: Acetyl-CoA acetyltransferase
著者Singh, R, Das, A.K.
登録日2022-08-20
公開日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of thiolase PFC_04095 from Pyrococcus furiosus
To Be Published
5ONC
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BU of 5onc by Molmil
Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch
分子名称: CHLORIDE ION, Steroid 3-ketoacyl-CoA thiolase
著者Schaefer, C, Kuper, J, Sampson, N.S, Kisker, C.
登録日2017-08-03
公開日2017-08-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.
ACS Infect Dis, 3, 2017
1AFW
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BU of 1afw by Molmil
THE 1.8 ANGSTROM CRYSTAL STRUCTURE OF THE DIMERIC PEROXISOMAL THIOLASE OF SACCHAROMYCES CEREVISIAE
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 3-KETOACETYL-COA THIOLASE
著者Mathieu, M, Wierenga, R.K.
登録日1997-03-15
公開日1997-06-16
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism.
J.Mol.Biol., 273, 1997
4W61
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Crystal structure of beta-ketoacyl thiolase B (BktB) from Ralstonia eutropha
分子名称: Beta-ketothiolase BktB
著者Fage, C.D, Keatinge-Clay, A.T.
登録日2014-08-19
公開日2015-09-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous beta-ketoacyl thiolase fromRalstonia eutropha.
J. Mol. Catal., B Enzym., 121, 2015
7FEA
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BU of 7fea by Molmil
PY14 in complex with Col-D
分子名称: (6~{R},7~{R},9~{E})-6,7-bis(oxidanyl)hexadeca-9,15-dien-11,13-diynoic acid, Acetyl-CoA C-acyltransferase
著者Lin, C.C, Ko, T.P, Huang, K.F, Yang, Y.L.
登録日2021-07-19
公開日2022-07-27
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Commun Biol, 5, 2022
4O99
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Crystal structure of Beta-ketothiolase (PhaA) from Ralstonia eutropha H16
分子名称: Acetyl-CoA acetyltransferase, GLYCEROL
著者Kim, E.J, Kim, J, Kim, S, Kim, K.J.
登録日2014-01-02
公開日2014-12-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Crystal structure and biochemical characterization of PhaA from Ralstonia eutropha, a polyhydroxyalkanoate-producing bacterium.
Biochem.Biophys.Res.Commun., 452, 2014
3GOA
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BU of 3goa by Molmil
Crystal structure of the Salmonella typhimurium FadA 3-ketoacyl-CoA thiolase
分子名称: 3-ketoacyl-CoA thiolase, CALCIUM ION, CHLORIDE ION, ...
著者Anderson, S.M, Skarina, T, Onopriyenko, O, Wawrzak, Z, Papazisi, L, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2009-03-18
公開日2009-03-31
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献

4WYS
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Crystal structure of thiolase from Escherichia coli
分子名称: Acetyl-CoA acetyltransferase
著者Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J.
登録日2014-11-18
公開日2015-10-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Nat Commun, 6, 2015
5ZQZ
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Structure of human mitochondrial trifunctional protein, tetramer
分子名称: Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta
著者Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J.
登録日2018-04-20
公開日2018-06-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4WYR
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Crystal structure of thiolase mutation (V77Q,N153Y,A286K) from Clostridium acetobutylicum
分子名称: Acetyl-CoA acetyltransferase, DI(HYDROXYETHYL)ETHER, GLYCEROL
著者Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J.
登録日2014-11-18
公開日2015-10-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Nat Commun, 6, 2015
6L2G
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Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase
分子名称: Acetyl-CoA-acetyltransferase, putative
著者Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W.
登録日2019-10-03
公開日2020-02-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
Appl.Environ.Microbiol., 86, 2020
5F0V
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BU of 5f0v by Molmil
X-ray crystal structure of a thiolase from Escherichia coli at 1.8 A resolution
分子名称: 1,2-ETHANEDIOL, Acetyl-CoA acetyltransferase
著者Ithayaraja, M, Neelanjana, J, Wierenga, R, Savithri, H.S, Murthy, M.R.N.
登録日2015-11-28
公開日2016-07-13
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a thiolase from Escherichia coli at 1.8 angstrom resolution.
Acta Crystallogr.,Sect.F, 72, 2016
6L2C
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Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase in complex with CoA
分子名称: Acetyl-CoA-acetyltransferase, putative, COENZYME A
著者Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W.
登録日2019-10-03
公開日2020-02-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
Appl.Environ.Microbiol., 86, 2020
7CW4
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BU of 7cw4 by Molmil
Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579
分子名称: Acetyl-CoA acetyltransferase, GLYCEROL
著者Hong, J, Kim, K.J.
登録日2020-08-27
公開日2020-10-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579.
Biochem.Biophys.Res.Commun., 533, 2020
5ZRV
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BU of 5zrv by Molmil
Structure of human mitochondrial trifunctional protein, octamer
分子名称: Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta
著者Liang, K, Li, N, Dai, J, Wang, X, Liu, P, Chen, X, Wang, C, Gao, N, Xiao, J.
登録日2018-04-25
公開日2018-06-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (7.7 Å)
主引用文献Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5F38
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BU of 5f38 by Molmil
X-ray crystal structure of a thiolase from Escherichia coli at 1.8 A resolution
分子名称: 1,2-ETHANEDIOL, Acetyl-CoA acetyltransferase, COENZYME A, ...
著者Ithayaraja, M, Neelanjana, J, Wierenga, R, Savithri, H.S, Murthy, M.R.N.
登録日2015-12-02
公開日2016-07-13
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a thiolase from Escherichia coli at 1.8 angstrom resolution.
Acta Crystallogr.,Sect.F, 72, 2016
3SS6
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BU of 3ss6 by Molmil
Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
分子名称: Acetyl-CoA acetyltransferase, POTASSIUM ION, SULFATE ION
著者Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2011-07-07
公開日2011-07-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
TO BE PUBLISHED
7CW5
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BU of 7cw5 by Molmil
Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579
分子名称: Acetyl-CoA acetyltransferase, COENZYME A
著者Hong, J, Kim, K.J.
登録日2020-08-27
公開日2020-10-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579.
Biochem.Biophys.Res.Commun., 533, 2020
5XZ5
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BU of 5xz5 by Molmil
Purification,crystallization and structural analysis of cytoplastic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae
分子名称: Acetyl-CoA acetyltransferase
著者Zhou, P.F, Zhu, Z.L.
登録日2017-07-11
公開日2018-07-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Purification,crystallization and structural analysis of cytoplastic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae
To Be Published
3SVK
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BU of 3svk by Molmil
Crystal structure of Acetyl-CoA acetyltransferase from Mycobacterium avium
分子名称: Acetyl-CoA acetyltransferase, CHLORIDE ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-07-12
公開日2011-08-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
5XYJ
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BU of 5xyj by Molmil
Purification,crystallization and structural analysis of cytoplastic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae
分子名称: Acetyl-CoA acetyltransferase, GLYCEROL
著者Zhou, P.F.
登録日2017-07-08
公開日2018-07-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Purification,crystallization and structural analysis of cytoplastic acetoacetyl-CoA thiolase from Saccharomyces cerevisiae
To Be Published
4UBT
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Structure of the C93S variant of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis in complex with a steroid and CoA.
分子名称: (2S)-2-[(8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoic acid (non-preferred name), Acetyl-CoA acetyltransferase FadA5, CHLORIDE ION, ...
著者Schaefer, C.M, Kisker, C.
登録日2014-08-13
公開日2014-12-17
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis.
Structure, 23, 2015
4B3H
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Crystal structure of Mycobacterium tuberculosis fatty acid beta- oxidation complex
分子名称: FATTY ACID BETA-OXIDATION COMPLEX ALPHA-CHAIN FADB, FATTY ACID BETA-OXIDATION COMPLEX BETA-CHAIN FADA, GLYCEROL, ...
著者Venkatesan, R, Wierenga, R.
登録日2012-07-24
公開日2013-03-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of Mycobacterial Beta-Oxidation Trifunctional Enzyme Reveals its Altered Assembly and Putative Substrate Channeling Pathway.
Acs Chem.Biol., 8, 2013
4UBU
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Structure of a modified C93S variant of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis in complex with CoA
分子名称: Acetyl-CoA acetyltransferase FadA5, COENZYME A, GLYCEROL
著者Schaefer, C.M, Kisker, C.
登録日2014-08-13
公開日2014-12-17
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis.
Structure, 23, 2015

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件を2024-10-16に公開中

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