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PDB: 367 件
2RHR
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P94L actinorhodin ketordeuctase mutant, with NADPH and Inhibitor Emodin
分子名称: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Korman, T.P, Tsai, S.-C.
登録日2007-10-09
公開日2008-08-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
Biochemistry, 47, 2008
4P38
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Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with AZD8329
分子名称: 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid, CHLORIDE ION, Corticosteroid 11-beta-dehydrogenase isozyme 1, ...
著者Ogg, D, Hargreaves, D, Gerhardt, S.
登録日2014-03-06
公開日2014-04-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Novel acidic 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).
J.Med.Chem., 55, 2012
6L1G
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BU of 6l1g by Molmil
Crystal structure of light-dependent protochlorophyllide oxidoreductase from Synechocystis sp. PCC 6803
分子名称: Light-dependent protochlorophyllide reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
著者Dong, C, Wang, X, Liu, L.
登録日2019-09-29
公開日2020-04-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of cyanobacterial light-dependent protochlorophyllide oxidoreductase.
Proc.Natl.Acad.Sci.USA, 117, 2020
1W4Z
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BU of 1w4z by Molmil
Structure of actinorhodin polyketide (actIII) Reductase
分子名称: FORMIC ACID, KETOACYL REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Hadfield, A.T, Limpkin, C, Teartasin, W, Simpson, T.J, Crosby, J, Crump, M.P.
登録日2004-08-03
公開日2004-12-10
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Crystal Structure of the Actiii Actinorhodin Polyketide Reductase; Proposed Mechanism for Acp and Polyketide Binding
Structure, 12, 2004
6USN
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BU of 6usn by Molmil
Co-crystal structure of SPR with compound 5
分子名称: (2-hydroxyphenyl)[3-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl]methanone, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Huang, X, Wang, K.
登録日2019-10-28
公開日2019-12-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.773 Å)
主引用文献Virtual screening to identify potent sepiapterin reductase inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
7N09
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BU of 7n09 by Molmil
Structural basis for branched substrate selectivity in a ketoreductase from Ascaris suum
分子名称: 3-hydroxyacyl-CoA dehydrogenase type-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Dong, H, Chang, M.C.Y.
登録日2021-05-25
公開日2021-08-11
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Branched Substrate Selectivity in a Ketoreductase from Ascaris suum
Acs Catalysis, 11, 2021
5WQN
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Crystal structure of a carbonyl reductase from Pseudomonas aeruginosa PAO1 (condition II)
分子名称: Probable dehydrogenase
著者Li, S, Wang, Y, Bartlam, M.
登録日2016-11-27
公開日2017-10-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1.
FEBS Lett., 591, 2017
4WEO
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Crystal Structure of a Putative acetoin(Diacetyl) Reductase Burkholderia cenocepacia
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2014-09-10
公開日2014-09-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal Structure of a Putative acetoin(Diacetyl) Reductase Burkholderia cenocepacia
to be published
2GDZ
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BU of 2gdz by Molmil
Crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with NAD+
分子名称: NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Pilka, E.S, Guo, K, Kavanagh, K, Von Delft, F, Arrowsmith, C, Weigelt, J, Edwards, A, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC)
登録日2006-03-17
公開日2006-04-04
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
Plos One, 5, 2010
7YPD
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BU of 7ypd by Molmil
Discovery and characterization of a new carbonyl reductase from Rhodotorula toluroides reducing fluoroketones, and X-ray analysis of the variant by rational engineering
分子名称: Carbonyl reductase, MAGNESIUM ION
著者Watanabe, Y, Asano, Y, Hibi, M.
登録日2022-08-03
公開日2024-02-07
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献Discovery and characterization of a new carbonyl reductase from Rhodotorula toluroides reducing fluoroketones, and X-ray analysis of the variant by rational engineering
To Be Published
7ULH
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BU of 7ulh by Molmil
Crystal Structure of a Short chain dehydrogenase from Mycobacterium avium 104
分子名称: Short chain dehydrogenase
著者Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2022-04-04
公開日2022-04-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Crystal Structure of a Short chain dehydrogenase from Mycobacterium avium 104
to be published
1E6W
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BU of 1e6w by Molmil
Rat brain 3-hydroxyacyl-CoA dehydrogenase binary complex with NADH and estradiol
分子名称: ESTRADIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE
著者Read, J.A, Powell, A.J, Brady, R.L.
登録日2000-08-23
公開日2001-05-25
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Recognition of Structurally Diverse Substrates by Type II 3-Hydroxyacyl-Coa Dehydrogenase (Hadh II) Amyloid-Beta Binding Alcohol Dehydrogenase (Abad)
J.Mol.Biol., 303, 2000
6R48
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Crystal structure of LPOR (Synechocystis) complexed with NADPH at 1.87A resolution.
分子名称: CHLORIDE ION, Light-dependent protochlorophyllide reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zhou, A, Feng, L.
登録日2019-03-22
公開日2019-10-30
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis.
Nature, 574, 2019
8I70
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Crystal structure of NADP-binding form of malonyl-CoA reductase C-domain from Chloroflexus aurantiacus
分子名称: GLYCEROL, L(+)-TARTARIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Kim, S, Kim, K.-J.
登録日2023-01-30
公開日2023-06-14
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity.
Int.J.Biol.Macromol., 242, 2023
8I6Z
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BU of 8i6z by Molmil
Crystal structure of apo-form of malonyl-CoA reductase C-domain from Chloroflexus aurantiacus
分子名称: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR
著者Kim, S, Kim, K.-J.
登録日2023-01-30
公開日2023-06-14
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity.
Int.J.Biol.Macromol., 242, 2023
6R46
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BU of 6r46 by Molmil
Crystal structure of LPOR (Thermosynechococcus elongatus) complexed with NADP+ at 2.5A resolution
分子名称: CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH-protochlorophyllide oxidoreductase, ...
著者Zhou, A, Feng, L.
登録日2019-03-22
公開日2019-10-30
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis.
Nature, 574, 2019
3LZ6
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BU of 3lz6 by Molmil
Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423
分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, N-adamantan-2-yl-1-ethyl-D-prolinamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Pauly, T.A.
登録日2010-03-01
公開日2011-05-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3M1A
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BU of 3m1a by Molmil
The Crystal Structure of a Short-chain Dehydrogenase from Streptomyces avermitilis to 2A
分子名称: ACETATE ION, Putative dehydrogenase, SODIUM ION
著者Stein, A.J, Evdokimova, E, Egorova, O, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
登録日2010-03-04
公開日2010-03-23
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Crystal Structure of a Short-chain Dehydrogenase from Streptomyces avermitilis to 2A
To be Published
1EQU
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BU of 1equ by Molmil
TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EQUILIN COMPLEXED WITH NADP+
分子名称: EQUILIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (ESTRADIOL 17 BETA-DEHYDROGENASE 1)
著者Sawicki, M.W, Erman, M, Puranen, T, Vihko, P, Ghosh, D.
登録日1998-12-02
公開日1999-12-02
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.
Proc.Natl.Acad.Sci.USA, 96, 1999
5ILO
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BU of 5ilo by Molmil
Crystal structure of photoreceptor dehydrogenase from Drosophila melanogaster
分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Photoreceptor dehydrogenase, isoform C
著者Hofmann, L, Tsybovsky, Y, Banerjee, S.
登録日2016-03-04
公開日2016-11-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.
Biochemistry, 55, 2016
5ILG
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Crystal structure of photoreceptor dehydrogenase from Drosophila melanogaster
分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Hofmann, L, Tsybovsky, Y, Banerjee, S.
登録日2016-03-04
公開日2016-11-16
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.
Biochemistry, 55, 2016
6ZZP
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BU of 6zzp by Molmil
Crystal structure of (R)-3-hydroxybutyrate dehydrogenase from Psychrobacter arcticus complexed with NAD+ and 3-oxovalerate
分子名称: 3-oxidanylidenepentanoic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative beta-hydroxybutyrate dehydrogenase
著者Machado, T.F.G, da Silva, R.G, Gloster, T.M, McMahon, S.A, Oehler, V.
登録日2020-08-04
公開日2020-10-07
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Dissecting the Mechanism of ( R )-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry.
Acs Catalysis, 10, 2020
4RZH
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BU of 4rzh by Molmil
Crystal structure of FabG from Synechocystis sp. PCC 6803
分子名称: 3-oxoacyl-[acyl-carrier protein] reductase
著者Liu, Y, Xue, S.
登録日2014-12-22
公開日2015-09-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure-directed construction of a high-performance version of the enzyme FabG from the photosynthetic microorganism Synechocystis sp. PCC 6803.
Febs Lett., 589, 2015
5FYD
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BU of 5fyd by Molmil
Structural and biochemical insights into 7beta-hydroxysteroid dehydrogenase stereoselectivity
分子名称: GLYCEROL, OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY PROTEIN
著者Savino, S, Ferrandi, E, Forneris, F, Rovida, S, Riva, S, Monti, D, Mattevi, A.
登録日2016-03-07
公開日2016-04-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and Biochemical Insights Into 7Beta-Hydroxysteroid Dehydrogenase Stereoselectivity.
Proteins, 84, 2016
5GT9
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The X-ray structure of 7beta-hydroxysteroid dehydrogenase
分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, short chain dehydrogenase/reductase family protein
著者Wang, F, Wang, R, Lv, Z, Chen, Q, Huo, X.
登録日2016-08-19
公開日2017-05-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of NADP(+)-bound 7 beta-hydroxysteroid dehydrogenase reveals two cofactor-binding modes
Acta Crystallogr F Struct Biol Commun, 73, 2017

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