4P38
Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with AZD8329
Summary for 4P38
Entry DOI | 10.2210/pdb4p38/pdb |
Related | 4HFR |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid, ... (5 entities in total) |
Functional Keywords | alpha beta, rossmann fold, nadp, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845 |
Total number of polymer chains | 2 |
Total formula weight | 60838.64 |
Authors | Ogg, D.,Hargreaves, D.,Gerhardt, S. (deposition date: 2014-03-06, release date: 2014-04-30, Last modification date: 2024-02-28) |
Primary citation | Scott, J.S.,deSchoolmeester, J.,Kilgour, E.,Mayers, R.M.,Packer, M.J.,Hargreaves, D.,Gerhardt, S.,Ogg, D.J.,Rees, A.,Selmi, N.,Stocker, A.,Swales, J.G.,Whittamore, P.R. Novel acidic 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J.Med.Chem., 55:10136-10147, 2012 Cited by PubMed: 23088558DOI: 10.1021/jm301252n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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