4P38
Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with AZD8329
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | polymer | 265 | 29216.9 | 2 | UniProt (P28845) Pfam (PF00106) | Homo sapiens (Human) | 11-beta-hydroxysteroid dehydrogenase 1,11-beta-HSD1 |
| 2 | C, F (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, G (A, B) | 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid | non-polymer | 421.5 | 2 | Chemie (21T) | |||
| 4 | E, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 29 | Chemie (HOH) |
Sequence modifications
A, B: 26 - 290 (UniProt: P28845)
| PDB | External Database | Details |
|---|---|---|
| Leu 179 | Met 179 | conflict |
| Arg 262 | Leu 262 | conflict |
| Ser 272 | Cys 272 | conflict |
| Glu 278 | Phe 278 | conflict |
| Trp 286 | Met 286 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58433.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2404.8 | |
| All* | Total formula weight | 60838.6 |
