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PDB: 277 件

4KBO
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Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form
分子名称: SODIUM ION, Stress-70 protein, mitochondrial
著者Amick, J, Page, R.C, Nix, J.C, Misra, S.
登録日2013-04-23
公開日2014-04-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.
Protein Sci., 23, 2014
4B9Q
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BU of 4b9q by Molmil
Open conformation of ATP-bound Hsp70 homolog DnaK
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION
著者Kopp, J, Mayer, M.P, Sinning, I.
登録日2012-09-06
公開日2012-11-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones
Mol.Cell, 48, 2012
6ZHI
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BU of 6zhi by Molmil
Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide
分子名称: ASN-ARG-LEU-LEU-LEU-THR-GLY, Heat shock protein 70
著者Schmidt, J, Vakonakis, I.
登録日2020-06-23
公開日2020-09-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure of the PfHsp70-x SBD
Acta Crystallographica Section F
6NHK
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Mortalin nucleotide binding domain in the ADP-bound state
分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
著者Page, R.C, Moseng, M.A, Nix, J.C.
登録日2018-12-23
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.777 Å)
主引用文献Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.
J.Phys.Chem.B, 123, 2019
2KHO
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BU of 2kho by Molmil
NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate
分子名称: Heat shock protein 70
著者Zuiderweg, E.R.P, Bertelsen, E.B.
登録日2009-04-10
公開日2009-05-12
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate.
Proc.Natl.Acad.Sci.USA, 106, 2009
5TKY
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BU of 5tky by Molmil
Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein
著者Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I.
登録日2016-10-10
公開日2016-11-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.
Nat Commun, 7, 2016
6P2U
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Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate
分子名称: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ...
著者Moseng, M.A, Page, R.C.
登録日2019-05-22
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin.
Febs Lett., 593, 2019
1U00
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HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC
分子名称: Chaperone protein hscA, IscU recognition peptide
著者Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E.
登録日2004-07-12
公開日2004-10-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC.
J.Mol.Biol., 342, 2004
5XI9
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Solution structure for human HSP70 substrate binding domain
分子名称: Heat shock 70 kDa protein 1A
著者Hoshikawa, M, Tochio, N, Tate, S.
登録日2017-04-26
公開日2018-05-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication.
Molecules, 23, 2018
6PMT
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Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate
分子名称: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ...
著者Moseng, M.A, Nix, J.C, Page, R.C.
登録日2019-07-02
公開日2020-07-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate
to be published
5XIR
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Solution structure for human HSP70 substrate binding domain L542Y mutant
分子名称: Heat shock 70 kDa protein 1A
著者Hoshikawa, M, Tochio, N, Tate, S.
登録日2017-04-27
公開日2018-05-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication.
Molecules, 23, 2018
1S3X
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The crystal structure of the human Hsp70 ATPase domain
分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70 kDa protein 1, ...
著者Sriram, M, Osipiuk, J, Freeman, B, Morimoto, R.I, Joachimiak, A.
登録日2004-01-14
公開日2004-01-20
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
Structure, 5, 1997
2V7Z
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Crystal structure of the 70-kDa heat shock cognate protein from Rattus norvegicus in post-ATP hydrolysis state
分子名称: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK COGNATE 71 KDA PROTEIN, PHOSPHATE ION
著者Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D.
登録日2007-08-02
公開日2008-04-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation.
J.Biol.Chem., 283, 2008
2V7Y
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Crystal structure of the molecular chaperone DnaK from Geobacillus kaustophilus HTA426 in post-ATP hydrolysis state
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION, ...
著者Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D.
登録日2007-08-02
公開日2008-04-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation.
J.Biol.Chem., 283, 2008
5UMB
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BU of 5umb by Molmil
Crystal structure of ATPase domain of Malaria GRP78 with ADP bound
分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ...
著者Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H.
登録日2017-01-26
公開日2022-07-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Repurposing drugs to target the malaria parasite unfolding protein response.
Sci Rep, 8, 2018
1HPM
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HOW POTASSIUM AFFECTS THE ACTIVITY OF THE MOLECULAR CHAPERONE HSC70. II. POTASSIUM BINDS SPECIFICALLY IN THE ATPASE ACTIVE SITE
分子名称: 44K ATPASE FRAGMENT (N-TERMINAL) OF 7O kD HEAT-SHOCK COGNATE PROTEIN, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
著者Wilbanks, S.M, Mckay, D.B.
登録日1995-03-24
公開日1995-07-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献How potassium affects the activity of the molecular chaperone Hsc70. II. Potassium binds specifically in the ATPase active site.
J.Biol.Chem., 270, 1995
1HJO
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ATPase domain of human heat shock 70kDa protein 1
分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ...
著者Osipiuk, J, Walsh, M.A, Freeman, B.C, Morimoto, R.I, Joachimiak, A.
登録日1998-10-13
公開日1998-10-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of a new crystal form of human Hsp70 ATPase domain.
Acta Crystallogr.,Sect.D, 55, 1999
1YUW
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crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
分子名称: Heat shock cognate 71 kDa protein
著者Jiang, J, Lafer, E.M, Prasad, K, Sousa, R.
登録日2005-02-14
公開日2005-10-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of interdomain communication in the Hsc70 chaperone
Mol.Cell, 20, 2005
7Q4R
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BU of 7q4r by Molmil
Crystal structure of human HSP72-NBD in complex with fragment 1
分子名称: 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide, Heat shock 70 kDa protein 1A, MAGNESIUM ION, ...
著者Le Bihan, Y.V, Westwood, I.M, van Montfort, R.L.M.
登録日2021-11-02
公開日2022-02-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70.
Molecules, 27, 2022
7PLK
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Crystal structure bovine Hsc70(aa1-554)E213A/D214A in complex with nicotinic-acid-derivative
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-pyrrol-1-ylpyridine-3-carboxylic acid, GLYCEROL, ...
著者Zehe, M, Grimm, C, Sotriffer, C.
登録日2021-08-31
公開日2022-09-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.48781371 Å)
主引用文献Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
6DFO
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Crystal structure of human GRP78 in complex with 8-bromoadenosine
分子名称: 8-bromoadenosine, Endoplasmic reticulum chaperone BiP
著者Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
登録日2018-05-15
公開日2019-05-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Crystal structure of human GRP78 in complex with 8-bromoadenosine
To be Published
6DO2
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Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
分子名称: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Endoplasmic reticulum chaperone BiP
著者Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
登録日2018-06-08
公開日2019-06-12
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
To Be Published
6DFM
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Crystal structure of human GRP78 in complex with 8-aminoadenosine
分子名称: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Endoplasmic reticulum chaperone BiP
著者Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
登録日2018-05-15
公開日2019-05-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Crystal structure of human GRP78 in complex with 8-aminoadenosine
To be Published
6SR6
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Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ...
著者Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I.
登録日2019-09-05
公開日2020-03-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb.
Nat Commun, 11, 2020
7RAX
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ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ...
著者Wang, W, Hendrickson, W.A.
登録日2021-07-04
公開日2023-07-05
最終更新日2024-07-17
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Conformational equilibria in allosteric control of Hsp70 chaperones.
Mol.Cell, 81, 2021

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件を2024-08-14に公開中

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