2O02
 
 | | Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to pathogenesis | | 分子名称: | 14-3-3 protein zeta/delta, BENZOIC ACID, ExoS (416-430) peptide | | 著者 | Ottmann, C, Yasmin, L, Weyand, M, Hauser, A.R, Wittinghofer, A, Hallberg, B. | | 登録日 | 2006-11-27 | | 公開日 | 2007-11-27 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis
Embo J., 26, 2007
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6F09
 | | Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide | | 分子名称: | 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8 | | 著者 | Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S. | | 登録日 | 2017-11-17 | | 公開日 | 2018-03-07 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.594 Å) | | 主引用文献 | Biophysical and structural insight into the USP8/14-3-3 interaction.
FEBS Lett., 592, 2018
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7ZIT
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6ZFG
 | | 14-3-3 zeta chimera with 18E6 and fusicoccin | | 分子名称: | 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL | | 著者 | Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. | | 登録日 | 2020-06-17 | | 公開日 | 2021-02-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms.
Nat Commun, 12, 2021
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6ZFD
 | | 14-3-3 zeta bound to the phosphorylated 18E6 C-terminus | | 分子名称: | 14-3-3 protein zeta/delta,Protein E6, GLYCEROL | | 著者 | Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. | | 登録日 | 2020-06-17 | | 公開日 | 2021-02-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms.
Nat Commun, 12, 2021
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6F08
 | | 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1) | | 分子名称: | 14-3-3 protein zeta/delta, PENTAETHYLENE GLYCOL, Son of sevenless homolog 1 | | 著者 | Ballone, A, Centorrino, F, Ottmann, C, Guo, S, Leysen, S. | | 登録日 | 2017-11-17 | | 公開日 | 2018-02-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural characterization of 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1).
J. Struct. Biol., 202, 2018
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8P1H
 | | Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor | | 分子名称: | 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ... | | 著者 | Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N. | | 登録日 | 2023-05-12 | | 公開日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein.
Biochem.Biophys.Res.Commun., 682, 2023
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5EXA
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4FJ3
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8A9G
 | | Binary complex of 14-3-3 zeta Glucocorticoid Receptor (GR) pT524 peptide stabilised by (R)-para chloropyrrolidone1 | | 分子名称: | 14-3-3 protein zeta/delta, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-[(2~{R})-3-(4-chlorophenyl)carbonyl-2-(4-nitrophenyl)-4-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-1-yl]-2-oxidanyl-benzoic acid, ... | | 著者 | Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. | | 登録日 | 2022-06-28 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.961 Å) | | 主引用文献 | Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.
J.Med.Chem., 65, 2022
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1QJA
 | | 14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) | | 分子名称: | 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE | | 著者 | Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. | | 登録日 | 1999-06-23 | | 公開日 | 1999-09-15 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
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7D8P
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1QJB
 | | 14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) | | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE | | 著者 | Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B. | | 登録日 | 1999-06-23 | | 公開日 | 1999-09-15 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
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2C1N
 | | Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE | | 著者 | Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C. | | 登録日 | 2005-09-16 | | 公開日 | 2005-11-02 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
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6YMO
 | | Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide | | 分子名称: | 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... | | 著者 | Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. | | 登録日 | 2020-04-09 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
J.Biol.Chem., 296, 2021
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5NAS
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6YO8
 | | Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide | | 分子名称: | 14-3-3 protein zeta/delta, Glucocorticoid receptor | | 著者 | Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. | | 登録日 | 2020-04-14 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
J.Biol.Chem., 296, 2021
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5D2D
 | | Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 | | 分子名称: | 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ... | | 著者 | Stevers, L.M, Leysen, S.F.R, Ottmann, C. | | 登録日 | 2015-08-05 | | 公開日 | 2016-03-16 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
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8WE2
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6FNC
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6FNA
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5ULO
 | | Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide | | 分子名称: | 1,2-ETHANEDIOL, 14-3-3 protein zeta/delta, TBC1 domain family member 7 peptide, ... | | 著者 | DONG, A, HU, J, MADIGAN, J, WALKER, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC) | | 登録日 | 2017-01-25 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
to be published
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4N7Y
 | | Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS | | 分子名称: | 14-3-3 protein zeta/delta, Exoenzyme S | | 著者 | Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. | | 登録日 | 2013-10-16 | | 公開日 | 2014-02-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4HKC
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4IHL
 | | Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A | | 分子名称: | (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ... | | 著者 | Molzan, M, Ottmann, C. | | 登録日 | 2012-12-19 | | 公開日 | 2013-09-25 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
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