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PDB: 65 件
8P1H
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BU of 8p1h by Molmil
Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor
分子名称: 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ...
著者Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N.
登録日2023-05-12
公開日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein.
Biochem.Biophys.Res.Commun., 682, 2023
6U2H
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BRAF dimer bound to 14-3-3
分子名称: 14-3-3 protein zeta/delta, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Serine/threonine-protein kinase B-raf
著者Liau, N.P.D, Hymowitz, S.G, Sudhamsu, J.
登録日2019-08-19
公開日2019-08-28
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.
Nat.Struct.Mol.Biol., 27, 2020
6RLZ
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Crystal Structure of 14-3-3zeta in complex with a macrocyclic 8-mer peptide derived from ExoS
分子名称: 14-3-3 protein zeta/delta, EtMe
著者Wallraven, K, Grossmann, T.N, Hennig, S.
登録日2019-05-03
公開日2020-03-18
最終更新日2020-03-25
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Adapting free energy perturbation simulations for large macrocyclic ligands: how to dissect contributions from direct binding and free ligand flexibility.
Chem Sci, 11, 2020
5XY9
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BU of 5xy9 by Molmil
Structure of the MST4 and 14-3-3 complex
分子名称: 14-3-3 protein zeta/delta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, GLYCEROL, ...
著者Shi, Z.B, Zhou, Z.C.
登録日2017-07-06
公開日2018-07-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.303 Å)
主引用文献Structure of the MST4 and 14-3-3 complex
To Be Published
4IHL
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Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
分子名称: (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ...
著者Molzan, M, Ottmann, C.
登録日2012-12-19
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.
Acs Chem.Biol., 8, 2013
3CU8
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BU of 3cu8 by Molmil
Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
分子名称: 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ...
著者Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C.
登録日2008-04-16
公開日2009-05-05
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Mol. Cell. Biol., 30, 2010
4WRQ
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Crystal Structure of 14-3-3 zeta with Chibby peptide
分子名称: 14-3-3 protein zeta/delta, Chibby
著者Killoran, R.C, Shilton, B.H, Choy, W.Y.
登録日2014-10-24
公開日2015-05-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.409 Å)
主引用文献Structural Analysis of the 14-3-3 zeta /Chibby Interaction Involved in Wnt/ beta-Catenin Signaling.
Plos One, 10, 2015
6Q0K
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Structure of a MAPK pathway complex
分子名称: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf
著者Park, E, Rawson, S, Jeon, H, Eck, M.J.
登録日2019-08-01
公開日2019-10-09
最終更新日2020-04-22
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
4BG6
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14-3-3 interaction with Rnd3 prenyl-phosphorylation motif
分子名称: 14-3-3 PROTEIN ZETA/DELTA, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FARNESYL, ...
著者Riou, P, Kjaer, S, Purkiss, A, O'Reilly, N, McDonald, N.Q.
登録日2013-03-23
公開日2013-05-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins.
Cell(Cambridge,Mass.), 153, 2013
1IB1
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CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX
分子名称: 14-3-3 ZETA ISOFORM, COA-S-ACETYL TRYPTAMINE, SEROTONIN N-ACETYLTRANSFERASE
著者Obsil, T, Ghirlando, R, Klein, D.C, Ganguly, S, Dyda, F.
登録日2001-03-26
公開日2001-05-02
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
Cell(Cambridge,Mass.), 105, 2001
8QDV
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BU of 8qdv by Molmil
Structure of 14-3-3 zeta delta C with the bivalent tau-pS214-pS324 peptide
分子名称: 14-3-3 protein zeta/delta, Microtubule-associated protein tau
著者van den Oetelaar, M.C.M, Brunsveld, L, Ottmann, C.
登録日2023-08-30
公開日2024-09-11
最終更新日2024-09-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献14-3-3zeta binding increases cytosolic phospho-Tau solubility by decreasing its condensation, aggregation, and microtubule association
To Be Published
5NAS
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Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide
分子名称: 14-3-3 protein zeta/delta, Phosphatidylinositol 4-kinase beta
著者Boura, E, Eisenreichova, A.
登録日2017-02-28
公開日2017-03-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide
To Be Published
5J31
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Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from ExoS
分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, Exoenzyme S
著者Wallraven, K, Cromm, P, Bier, D, Glas, A, Grossmann, T.
登録日2016-03-30
公開日2016-10-19
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis.
Chembiochem, 17, 2016
3RDH
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BU of 3rdh by Molmil
X-ray induced covalent inhibition of 14-3-3
分子名称: 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION
著者Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X.
登録日2011-04-01
公開日2011-09-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.
Proc.Natl.Acad.Sci.USA, 108, 2011
2O02
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BU of 2o02 by Molmil
Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to pathogenesis
分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, ExoS (416-430) peptide
著者Ottmann, C, Yasmin, L, Weyand, M, Hauser, A.R, Wittinghofer, A, Hallberg, B.
登録日2006-11-27
公開日2007-11-27
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis
Embo J., 26, 2007
3NKX
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BU of 3nkx by Molmil
Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
分子名称: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase
著者Schumacher, B, Weyand, M, Ottmann, C.
登録日2010-06-21
公開日2010-09-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling
Mol.Cell.Biol., 30, 2010
2WH0
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BU of 2wh0 by Molmil
Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon
分子名称: 14-3-3 PROTEIN ZETA/DELTA, CALCIUM ION, PROTEIN KINASE C EPSILON TYPE, ...
著者Kostelecky, B, Saurin, A.T, Purkiss, A, Parker, P.J, McDonald, N.Q.
登録日2009-04-28
公開日2009-08-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Recognition of an Intra-Chain Tandem 14-3-3 Binding Site within Pkc Epsilon.
Embo Rep., 10, 2009
6EF5
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BU of 6ef5 by Molmil
14-3-3 with peptide
分子名称: 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN
著者Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W.
登録日2018-08-16
公開日2019-10-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献14-3-3 with peptide
To Be Published
6EJL
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Structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif
分子名称: 14-3-3 protein zeta/delta, Mitogen-activated protein kinase kinase kinase 5
著者Petrvalska, O, Lentini Santo, D, Obsilova, V, Obsil, T.
登録日2017-09-21
公開日2017-11-08
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.382 Å)
主引用文献Crystal structure of 14-3-3 zeta in complex with ASK1 14-3-3 binding motif
To Be Published
1QJA
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
分子名称: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
著者Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B.
登録日1999-06-23
公開日1999-09-15
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
2C1J
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Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
分子名称: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
著者Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C.
登録日2005-09-15
公開日2005-11-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
5ULO
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Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
分子名称: 1,2-ETHANEDIOL, 14-3-3 protein zeta/delta, TBC1 domain family member 7 peptide, ...
著者DONG, A, HU, J, MADIGAN, J, WALKER, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC)
登録日2017-01-25
公開日2018-01-31
最終更新日2024-09-25
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
to be published
2C1N
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Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3
分子名称: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
著者Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C.
登録日2005-09-16
公開日2005-11-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
8WF6
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14-3-3 zeta complexed with S559 phosphorylated peptide derived from GPIb alpha cytoplasmic domain
分子名称: 14-3-3 protein zeta/delta, S559 phosphorylated peptide, SUCCINIC ACID
著者Shu, Z.M, Zhou, A.W.
登録日2023-09-19
公開日2024-09-25
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Cryo-EM structure of GPIb-IX Complex
To Be Published
8WE2
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14-3-3 zeta complexed with S609 phosphorylated peptide derived from GPIb alpha cytoplasmic domain
分子名称: 14-3-3 protein zeta/delta, S609 phosphorylated peptide
著者Shu, Z.M, Zhou, A.W.
登録日2023-09-16
公開日2024-09-25
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structure of 14-3-3 zeta complexed with phosphorylated peptides derived from GPIb alpha cytoplasmic domain
To Be Published

 

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