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PDB: 53 件
2ESK
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BU of 2esk by Molmil
Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b, wild-type
分子名称: Ubiquitin-conjugating enzyme E2 D2
著者Ozkan, E, Yu, H, Deisenhofer, J.
登録日2005-10-26
公開日2005-12-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases
Proc.Natl.Acad.Sci.Usa, 102, 2005
6SQO
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BU of 6sqo by Molmil
Crystal structure of human MDM2 RING domain homodimer bound to UbcH5B-Ub
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, NITRATE ION, ...
著者Magnussen, H.M, Ahmed, S.F, Huang, D.T.
登録日2019-09-04
公開日2020-05-06
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020
2ESQ
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BU of 2esq by Molmil
Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ser94Gly
分子名称: Ubiquitin-conjugating enzyme E2 D2
著者Ozkan, E, Yu, H, Deisenhofer, J.
登録日2005-10-26
公開日2005-12-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases
Proc.Natl.Acad.Sci.Usa, 102, 2005
2ESO
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BU of 2eso by Molmil
Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ile37Ala
分子名称: Ubiquitin-conjugating enzyme E2 D2
著者Ozkan, E, Yu, H, Deisenhofer, J.
登録日2005-10-26
公開日2005-12-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases
Proc.Natl.Acad.Sci.Usa, 102, 2005
2ESP
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BU of 2esp by Molmil
Human ubiquitin-conjugating enzyme (E2) UbcH5b mutant Ile88Ala
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Ubiquitin-conjugating enzyme E2 D2
著者Ozkan, E, Yu, H, Deisenhofer, J.
登録日2005-10-26
公開日2005-12-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases
Proc.Natl.Acad.Sci.Usa, 102, 2005
4V3L
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BU of 4v3l by Molmil
RNF38-UB-UbcH5B-Ub complex
分子名称: 1,2-ETHANEDIOL, E3 UBIQUITIN-PROTEIN LIGASE RNF38, POLYUBIQUITIN-C, ...
著者Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T.
登録日2014-10-20
公開日2015-04-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
7AI0
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BU of 7ai0 by Molmil
Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
著者Magnussen, H.M, Huang, D.T.
登録日2020-09-25
公開日2021-01-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.559 Å)
主引用文献Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
5D1M
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BU of 5d1m by Molmil
Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (P199A)
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ...
著者Liang, Y.-H, Li, S, Weissman, A.M, Ji, X.
登録日2015-08-04
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.581 Å)
主引用文献Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
3L1Y
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BU of 3l1y by Molmil
Crystal structure of human UBC4 E2 conjugating enzyme
分子名称: Ubiquitin-conjugating enzyme E2 D2
著者Benirschke, R, Thompson, J.R, Mer, G.
登録日2009-12-14
公開日2010-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
5D1L
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BU of 5d1l by Molmil
Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (Y165A)
分子名称: DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, OXALATE ION, ...
著者Liang, Y.-H, Li, S, Weissman, A.M, Ji, X.
登録日2015-08-04
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.618 Å)
主引用文献Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
6HPR
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BU of 6hpr by Molmil
Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub
分子名称: Baculoviral IAP repeat-containing protein 2, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ...
著者Patel, A, Huang, D.T.
登録日2018-09-21
公開日2018-12-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex.
J. Biol. Chem., 294, 2019
8GBQ
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BU of 8gbq by Molmil
Structure of RNF125 in complex with UbcH5b
分子名称: E3 ubiquitin-protein ligase RNF125, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ...
著者Middleton, A.J, Day, C.L, Fokkens, T.J.
登録日2023-02-27
公開日2023-07-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation.
Structure, 31, 2023
5D1K
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BU of 5d1k by Molmil
Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ...
著者Liang, Y.-H, Li, S, Weissman, A.M, Ji, X.
登録日2015-08-04
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
7BOL
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BU of 7bol by Molmil
ubiquitin-conjugating enzyme, Ube2D2
分子名称: Ubiquitin-conjugating enzyme E2 D2
著者Lee, S.O, Ryu, K.S, Chi, S.-W.
登録日2020-03-19
公開日2021-03-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.797 Å)
主引用文献MUL1-RING recruits the substrate, p53-TAD as a complex with UBE2D2-UB conjugate.
Febs J., 2022
6W7Z
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BU of 6w7z by Molmil
RNF12 RING domain in complex with Ube2d2
分子名称: E3 ubiquitin-protein ligase RLIM, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ...
著者Middleton, A.J, Day, C.L.
登録日2020-03-19
公開日2020-05-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains.
J.Mol.Biol., 432, 2020
5ULF
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BU of 5ulf by Molmil
Crystal Structure of a UbcH5b~Ub conjugate
分子名称: GLYCEROL, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2
著者Middleton, A.J, Day, C.L, Wright, J.D.
登録日2017-01-24
公開日2017-06-07
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of new non-covalent ubiquitin binding sites on UbcH5
To be published
3TGD
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BU of 3tgd by Molmil
Crystal structure of the human ubiquitin-conjugating enzyme (E2) UbcH5b
分子名称: Ubiquitin-conjugating enzyme E2 D2
著者Page, R.C, Amick, J, Misra, S.
登録日2011-08-17
公開日2011-08-31
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the human ubiquitin-conjugating enzyme (E2) UbcH5b
To be Published
6SQS
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BU of 6sqs by Molmil
Crystal structure of cat phospho-Ser429 MDM2 RING domain bound to UbcH5B-Ub
分子名称: E3 ubiquitin-protein ligase Mdm2, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 D2, ...
著者Magnussen, H.M, Ahmed, S.F, Huang, D.T.
登録日2019-09-04
公開日2020-05-06
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020
4LDT
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BU of 4ldt by Molmil
The structure of h/ceOTUB1-ubiquitin aldehyde-UBCH5B~Ub
分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Ubiquitin, ...
著者Wiener, R, DiBello, A.T, Lombardi, P.M, Guzzo, C.M, Zhang, X, Matunis, M.J, Wolberger, C.
登録日2013-06-25
公開日2013-08-14
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Nat.Struct.Mol.Biol., 20, 2013
5D0M
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BU of 5d0m by Molmil
Structure of UbE2D2:RNF165:Ub complex
分子名称: PHOSPHATE ION, Polyubiquitin-B, RING finger protein 165, ...
著者Wright, J.D, Day, C.L, Mace, P.D.
登録日2015-08-03
公開日2015-12-09
最終更新日2016-01-20
実験手法X-RAY DIFFRACTION (1.913 Å)
主引用文献Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.
Nat.Struct.Mol.Biol., 23, 2016
2CLW
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BU of 2clw by Molmil
Crystal structure of human ubiquitin-conjugating enzyme UbcH5B
分子名称: GLYCEROL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E2 D2
著者Dodd, R.B, Read, R.J.
登録日2006-05-02
公開日2007-06-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.945 Å)
主引用文献Structures of Two Human Ubiquitin-Conjugating Enzymes from Twinned Crystals
To be Published
5ULH
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BU of 5ulh by Molmil
Structure of RNF165 in complex with a UbcH5b~Ub conjugate
分子名称: E3 ubiquitin-protein ligase RNF165, GLYCEROL, THIOCYANATE ION, ...
著者Middleton, A.J, Day, C.L, Wright, J.D.
登録日2017-01-24
公開日2017-06-07
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Discovery of new non-covalent ubiquitin binding sites on UbcH5
To be published
4V3K
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BU of 4v3k by Molmil
RNF38-UbcH5B-UB complex
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
著者Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T.
登録日2014-10-20
公開日2015-04-08
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
7AI1
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BU of 7ai1 by Molmil
Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
著者Magnussen, H.M, Huang, D.T.
登録日2020-09-25
公開日2021-01-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
5MNJ
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BU of 5mnj by Molmil
Structure of MDM2-MDMX-UbcH5B-ubiquitin complex
分子名称: E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, Protein Mdm4, ...
著者Klejnot, M, Huang, D.T.
登録日2016-12-13
公開日2017-05-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Nat. Struct. Mol. Biol., 24, 2017

 

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