8SYL
 
 | | Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs | | 分子名称: | (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | 著者 | Seely, S.M, Gagnon, M.G. | | 登録日 | 2023-05-25 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome.
Nat Commun, 14, 2023
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7P3K
 | | Cryo-EM structure of 70S ribosome stalled with TnaC peptide (control) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Buschauer, R, Komar, T, Becker, T, Berninghausen, O, Cheng, J, Beckmann, R. | | 登録日 | 2021-07-08 | | 公開日 | 2021-10-27 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide.
Nucleic Acids Res., 49, 2021
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7ST2
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7OT5
 | | CspA-70 cotranslational folding intermediate 1 | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Agirrezabala, X, Samatova, E, Macher, M, Liutkute, M, Gil-Carton, D, Novacek, J, Valle, M, Rodnina, M.V. | | 登録日 | 2021-06-09 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | A switch from alpha-helical to beta-strand conformation during co-translational protein folding.
Embo J., 41, 2022
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5AFI
 | | 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Fischer, N, Neumann, P, Konevega, A.L, Bock, L.V, Ficner, R, Rodnina, M.V, Stark, H. | | 登録日 | 2015-01-22 | | 公開日 | 2015-03-11 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure of the E. coli ribosome-EF-Tu complex at <3 angstrom resolution by Cs-corrected cryo-EM.
Nature, 520, 2015
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7B5K
 | | E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain. | | 分子名称: | 16S rRNA, 2-[[[(3~{R},5~{R})-3-azanyl-6-(3-azanylpropylamino)-5-oxidanyl-hexanoyl]amino]-methyl-amino]ethanoic acid, 23S rRNA, ... | | 著者 | Albers, S, Beckert, B, Matthies, M, Schuster, R, Riedner, M, Seuring, C, Sanyal, S, Torda, A, Wilson, N.D, Ignatova, Z. | | 登録日 | 2020-12-03 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Harnessing evolutionarily flexibility in tRNAs to maximize nonsense suppression activities
Nat Commun, 2021
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6I7V
 | | Ribosomal protein paralogs bL31 and bL36 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | | 著者 | Pulk, A, Cate, J.H.D, Remme, J, Lilleorg, S, Reier, K, Peil, L, Liiv, A, Tammsalu, T. | | 登録日 | 2018-11-19 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Bacterial ribosome heterogeneity: Changes in ribosomal protein composition during transition into stationary growth phase.
Biochimie, 156, 2018
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7OIZ
 | | Cryo-EM structure of 70S ribosome stalled with TnaC peptide | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Su, T, Kudva, R, Becker, T, Berninghausen, O, Heijne, G, Cheng, J, Beckmann, R. | | 登録日 | 2021-05-13 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide.
Nucleic Acids Res., 49, 2021
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7TOS
 | | E. coli 70S ribosomes bound with the ALS/FTD-associated dipeptide repeat protein PR20 | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | 登録日 | 2022-01-24 | | 公開日 | 2022-05-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
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7NSO
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7O19
 | | Cryo-EM structure of an Escherichia coli TnaC-ribosome complex stalled in response to L-tryptophan | | 分子名称: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | 著者 | van der Stel, A.X, Gordon, E.R, Sengupta, A, Martinez, A.K, Klepacki, D, Perry, T.N, Herrero del Valle, A, Vazquez-Laslop, N, Sachs, M.S, Cruz-Vera, L.R, Innis, C.A. | | 登録日 | 2021-03-29 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling.
Nat Commun, 12, 2021
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8G7P
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4U20
 | | Crystal structure of the E. coli ribosome bound to flopristin. | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Noeske, J, Huang, J, Olivier, N.B, Giacobbe, R.A, Zambrowski, M, Cate, J.H.D. | | 登録日 | 2014-07-16 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Synergy of streptogramin antibiotics occurs independently of their effects on translation.
Antimicrob.Agents Chemother., 58, 2014
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4U24
 | | Crystal structure of the E. coli ribosome bound to dalfopristin. | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Noeske, J, Huang, J, Olivier, N.B, Giacobbe, R.A, Zambrowski, M, Cate, J.H.D. | | 登録日 | 2014-07-16 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Synergy of streptogramin antibiotics occurs independently of their effects on translation.
Antimicrob.Agents Chemother., 58, 2014
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4U25
 | | Crystal structure of the E. coli ribosome bound to virginiamycin M1. | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Noeske, J, Huang, J, Olivier, N.B, Giacobbe, R.A, Zambrowski, M, Cate, J.H.D. | | 登録日 | 2014-07-16 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Synergy of streptogramin antibiotics occurs independently of their effects on translation.
Antimicrob.Agents Chemother., 58, 2014
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5NWY
 | | 2.9 A cryo-EM structure of VemP-stalled ribosome-nascent chain complex | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Su, T, Cheng, J, Sohmen, D, Hedman, R, Berninghausen, O, von Heijne, G, Wilson, D.N, Beckmann, R. | | 登録日 | 2017-05-08 | | 公開日 | 2017-07-19 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.
Elife, 6, 2017
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4U1U
 | | Crystal structure of the E. coli ribosome bound to quinupristin. | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Noeske, J, Huang, J, Olivier, N.B, Giacobbe, R.A, Zambrowski, M, Cate, J.H.D. | | 登録日 | 2014-07-16 | | 公開日 | 2014-07-30 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Synergy of streptogramin antibiotics occurs independently of their effects on translation.
Antimicrob.Agents Chemother., 58, 2014
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5J91
 | | Structure of the Wild-type 70S E coli ribosome bound to Tigecycline | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | | 著者 | Cocozaki, A, Ferguson, A. | | 登録日 | 2016-04-08 | | 公開日 | 2016-07-06 | | 最終更新日 | 2016-08-03 | | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | | 主引用文献 | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.
Proc.Natl.Acad.Sci.USA, 113, 2016
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6HRM
 | | E. coli 70S d2d8 stapled ribosome | | 分子名称: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | 著者 | Schmied, W.H, Tnimov, Z, Uttamapinant, C, Rae, C.D, Fried, S.D, Chin, J.W. | | 登録日 | 2018-09-27 | | 公開日 | 2018-12-19 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Controlling orthogonal ribosome subunit interactions enables evolution of new function.
Nature, 564, 2018
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5MDV
 | | Structure of ArfA and RF2 bound to the 70S ribosome (accommodated state) | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | James, N.R, Brown, A, Gordiyenko, Y, Ramakrishnan, V. | | 登録日 | 2016-11-13 | | 公開日 | 2016-12-14 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Translational termination without a stop codon.
Science, 354, 2016
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5WFS
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4V9D
 | | Structures of the bacterial ribosome in classical and hybrid states of tRNA binding | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Dunkle, J.A, Wang, L, Feldman, M.B, Pulk, A, Chen, V.B, Kapral, G.J, Noeske, J, Richardson, J.S, Blanchard, S.C, Cate, J.H.D. | | 登録日 | 2012-07-31 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.
Science, 332, 2011
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5IQR
 | | Structure of RelA bound to the 70S ribosome | | 分子名称: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | 著者 | Brown, A, Fernandez, I.S, Gordiyenko, Y, Ramakrishnan, V. | | 登録日 | 2016-03-11 | | 公開日 | 2016-05-04 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Ribosome-dependent activation of stringent control.
Nature, 534, 2016
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7Q4K
 | | Erythromycin-stalled Escherichia coli 70S ribosome with streptococcal MsrDL nascent chain | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Fostier, C.R, Ousalem, F, Soufari, H, Leroy, E.C, Ngo, S, Innis, A, Hashem, Y, Boel, G. | | 登録日 | 2021-10-31 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Regulation of the macrolide resistance ABC-F translation factor MsrD.
Nat Commun, 14, 2023
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8AP4
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