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PDB: 20 件
6PFO
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Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (16-32)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin, Maltodextrin-binding protein,Calcitonin receptor, ...
著者Lee, S, Pioszak, A.A.
登録日2019-06-21
公開日2020-02-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics.
J.Mol.Biol., 432, 2020
8F0K
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BU of 8f0k by Molmil
Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Sexton, P.M, Wootten, D.L.
登録日2022-11-03
公開日2023-08-02
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F2B
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BU of 8f2b by Molmil
Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
登録日2022-11-07
公開日2023-08-02
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F0J
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BU of 8f0j by Molmil
Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
登録日2022-11-03
公開日2023-08-02
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
5II0
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BU of 5ii0 by Molmil
Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue
分子名称: Calcitonin, Calcitonin receptor, SODIUM ION, ...
著者Johansson, E, Reedtz-Runge, S.
登録日2016-03-01
公開日2016-05-11
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.097 Å)
主引用文献Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography.
J.Biol.Chem., 291, 2016
8F2A
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BU of 8f2a by Molmil
Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5 conformation)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cao, J, Sexton, P.M, Wootten, D.L, Radostin, D.
登録日2022-11-07
公開日2023-08-02
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
7TYF
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BU of 7tyf by Molmil
Human Amylin1 Receptor in complex with Gs and rat amylin peptide
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-13
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TZF
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BU of 7tzf by Molmil
Human Amylin3 Receptor in complex with Gs and rat amylin peptide
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-15
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
9AUC
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BU of 9auc by Molmil
Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin gene-related peptide 1, ...
著者Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M.
登録日2024-02-28
公開日2024-04-24
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.
Biochemistry, 63, 2024
7TYX
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BU of 7tyx by Molmil
Human Amylin2 Receptor in complex with Gs and rat amylin peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-14
公開日2022-03-30
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (2.55 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TYN
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BU of 7tyn by Molmil
Calcitonin Receptor in complex with Gs and salmon calcitonin peptide
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-13
公開日2022-03-30
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TYO
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BU of 7tyo by Molmil
Calcitonin receptor in complex with Gs and human calcitonin peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-14
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
6PGQ
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BU of 6pgq by Molmil
Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (22-32)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Calcitonin, ...
著者Lee, S, Pioszak, A.A.
登録日2019-06-24
公開日2020-02-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics.
J.Mol.Biol., 432, 2020
7TYY
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BU of 7tyy by Molmil
Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-14
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TYW
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BU of 7tyw by Molmil
Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-14
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TYL
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BU of 7tyl by Molmil
Calcitonin Receptor in complex with Gs and rat amylin peptide, bypass motif
分子名称: Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-13
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TYH
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BU of 7tyh by Molmil
Human Amylin2 Receptor in complex with Gs and human calcitonin peptide
分子名称: Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-13
公開日2022-03-23
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TYI
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BU of 7tyi by Molmil
Calcitonin Receptor in complex with Gs and rat amylin peptide, CT-like state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
登録日2022-02-13
公開日2022-03-30
最終更新日2022-04-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献A structural basis for amylin receptor phenotype.
Science, 375, 2022
6NIY
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BU of 6niy by Molmil
A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex
分子名称: Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者dal Maso, E, Glukhova, A, Zhu, Y, Garcia-Nafria, J, Tate, C.G, Atanasio, S, Reynolds, C.A, Ramirez-Aportela, E, Carazo, J.-M, Hick, C.A, Furness, S.G.B, Hay, D.L, Liang, Y.-L, Miller, L.J, Christopoulos, A, Wang, M.-W, Wootten, D, Sexton, P.M.
登録日2019-01-02
公開日2019-01-23
最終更新日2020-04-08
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献The Molecular Control of Calcitonin Receptor Signaling.
Acs Pharmacol Transl Sci, 2, 2019
5UZ7
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BU of 5uz7 by Molmil
Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex
分子名称: Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Liang, Y.L, Khoshouei, M, Radjainia, M, Zhang, Y, Glukhova, A, Tarrasch, J, Thal, D.M, Furness, S.G.B, Christopoulos, G, Coudrat, T, Danev, R, Baumeister, W, Miller, L.J, Christopoulos, A, Kobilka, B.K, Wootten, D, Skiniotis, G, Sexton, P.M.
登録日2017-02-24
公開日2017-05-03
最終更新日2018-07-18
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.
Nature, 546, 2017

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