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PDB: 26 件
7SO5
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Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B
分子名称: Fab B2 HC, Fab B2 LC, Toxin B
著者Liu, J.
登録日2021-10-29
公開日2022-05-11
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.797 Å)
主引用文献Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B.
Curr Res Struct Biol, 4, 2022
7LOU
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Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and isofagomine
分子名称: 1,2-ETHANEDIOL, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, Glucosyltransferase TcdB, ...
著者Harijan, R.K, Paparella, A.S, Aboulache, B.L, Bonanno, J.B, Almo, S.C, Schramm, V.L.
登録日2021-02-10
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.
Nat Commun, 12, 2021
5UQM
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Clostridium difficile Toxin B (TcdB) glucosyltransferase domain in complex with U2F
分子名称: MANGANESE (II) ION, SULFATE ION, Toxin B, ...
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
5UQN
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Clostridium difficile Toxin B (TcdB) glucosyltransferase domain in complex with U2F
分子名称: MANGANESE (II) ION, SULFATE ION, Toxin B, ...
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
6OQ8
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Structure of the GTD domain of Clostridium difficile toxin B in complex with VHH 7F
分子名称: 7F, Toxin B
著者Chen, P, Lam, K, Jin, R.
登録日2019-04-25
公開日2019-07-10
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
2BVL
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BU of 2bvl by Molmil
Crystal structure of the catalytic domain of toxin B from Clostridium difficile in complex with UDP, Glc and manganese ion
分子名称: HEXATANTALUM DODECABROMIDE, MANGANESE (II) ION, SULFATE ION, ...
著者Reinert, D.J, Jank, T, Aktories, K, Schulz, G.E.
登録日2005-06-30
公開日2005-08-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
7LOV
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BU of 7lov by Molmil
Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and noeuromycin
分子名称: (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, GLYCEROL, MANGANESE (II) ION, ...
著者Harijan, R.K, Paparella, A.S, Aboulache, B.L, Bonanno, J.B, Almo, S.C, Schramm, V.L.
登録日2021-02-10
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.
Nat Commun, 12, 2021
4NC2
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BU of 4nc2 by Molmil
Crystal structure of TcdB-B1 bound to B39 VHH
分子名称: B39 VHH, Toxin B
著者Murase, T, Eugenio, L, Schorr, M, Hussack, G, Tanha, J, Kitova, E.N, Klassen, J.S, Ng, K.K.S.
登録日2013-10-23
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Antibody Recognition in the Receptor-binding Domains of Toxins A and B from Clostridium difficile.
J.Biol.Chem., 289, 2014
6C0B
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Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-2, MALONATE ION, ...
著者Chen, P, Lam, K, Jin, R.
登録日2017-12-28
公開日2018-05-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B.
Science, 360, 2018
2BVM
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Crystal structure of the catalytic domain of toxin B from Clostridium difficile in complex with UDP, Glc and manganese ion
分子名称: MANGANESE (II) ION, SULFATE ION, TOXIN B, ...
著者Reinert, D.J, Jank, T, Aktories, K, Schulz, G.E.
登録日2005-06-30
公開日2005-08-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural Basis for the Function of Clostridium Difficile Toxin B.
J.Mol.Biol., 351, 2005
5UQT
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Clostridium difficile Toxin B (TcdB) glucosyltransferase domain co-crystallized with apigenin
分子名称: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, MANGANESE (II) ION, Toxin B
著者Alvin, J.W, Lacy, D.B.
登録日2017-02-08
公開日2017-05-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
J. Struct. Biol., 198, 2017
7S0Y
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Structures of TcdB in complex with Cdc42
分子名称: Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Zheng, L, Rongsheng, J, Peng, C.
登録日2021-08-31
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B.
Sci Adv, 7, 2021
4NP4
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Clostridium difficile toxin B CROP domain in complex with FAB domains of neutralizing antibody bezlotoxumab
分子名称: Toxin B, bezlotoxumab heavy chain, bezlotoxumab light chain
著者Orth, P, Xiao, L, Hernandez, L.D, Reichert, P, Sheth, P, Beaumont, M, Murgolo, N, Ermakov, G, DiNunzio, E, Racine, F, Karczewski, J, Secore, S, Ingram, R.N, Mayhood, T, Strickland, C, Therien, A.G.
登録日2013-11-20
公開日2014-05-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography.
J.Biol.Chem., 289, 2014
6OQ6
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BU of 6oq6 by Molmil
Structure of the pore forming fragment of Clostridium difficile toxin B in complex with VHH 5D
分子名称: 5D, Toxin B
著者Chen, P, Lam, K, Jin, R.
登録日2019-04-25
公開日2019-07-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
7ML7
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BU of 7ml7 by Molmil
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
分子名称: Chondroitin sulfate proteoglycan 4, Toxin B, ZINC ION
著者Chen, P, Jin, R.
登録日2021-04-27
公開日2021-06-09
最終更新日2021-06-30
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.
Nat Commun, 12, 2021
8QEO
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BU of 8qeo by Molmil
cryo-EM structure complex of Frizzled-7 and Clostridioides difficile toxin B
分子名称: Frizzled-7, Toxin B, ZINC ION
著者Kinsolving, J, Bous, J.
登録日2023-09-01
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD 7.
Cell Rep, 43, 2024
7N8X
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BU of 7n8x by Molmil
Partial C. difficile TcdB and CSPG4 fragment
分子名称: Chondroitin sulfate proteoglycan 4, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-16
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
8QEN
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BU of 8qen by Molmil
cryo-EM structure of apo Clostridioides difficile toxin B
分子名称: Toxin B, ZINC ION
著者Kinsolving, J, Bous, J, Structural Genomics Consortium (SGC)
登録日2023-09-01
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD 7.
Cell Rep, 43, 2024
7SO7
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BU of 7so7 by Molmil
Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B
分子名称: FAB B1 LC, Fab B1 HC, Toxin B
著者Liu, J.
登録日2021-10-29
公開日2022-05-11
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.59 Å)
主引用文献Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B.
Curr Res Struct Biol, 4, 2022
7N95
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state 1 of TcdB and FZD2 at pH5
分子名称: Frizzled-2, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-16
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9Q
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State 3 of TcdB and FZD2 at pH5
分子名称: Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9Y
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BU of 7n9y by Molmil
Full-length TcdB and CSPG4 (401-560) complex
分子名称: Chondroitin sulfate proteoglycan 4, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N97
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State 2 of TcdB and FZD2 at pH5
分子名称: Frizzled-2, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-17
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Structural Basis for Receptor Recognition of the Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9S
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TcdB and frizzled-2 CRD complex
分子名称: Frizzled-2, Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published
7N9R
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state 4 of TcdB and FZD2 at pH5
分子名称: Toxin B
著者Jiang, M, Zhang, J.
登録日2021-06-18
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification
To Be Published

 

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