7ML7

Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

Summary for 7ML7

• Entry DOI: 10.2210/pdb7ml7/pdb
• EMDB information: 23909
• Descriptor: Toxin B, Chondroitin sulfate proteoglycan 4, ZINC ION (3 entities in total)
• Functional Keywords: cspg4, tcdb, clostridioides difficile infection, toxin
• Biological source: Clostridioides difficile (Peptoclostridium difficile); More
• Total number of polymer chains: 2
• Total formula weight: 311116.24

Authors

Chen, P.,Jin, R. (deposition date: 2021-04-27, release date: 2021-06-09, Last modification date: 2021-06-30)

• Primary citation: Chen, P.,Zeng, J.,Liu, Z.,Thaker, H.,Wang, S.,Tian, S.,Zhang, J.,Tao, L.,Gutierrez, C.B.,Xing, L.,Gerhard, R.,Huang, L.,Dong, M.,Jin, R.; Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.; Nat Commun, 12:3748-3748, 2021; PubMed: 34145250; DOI: 10.1038/s41467-021-23878-3

Experimental method

ELECTRON MICROSCOPY (3.17 Å)