4NP4

Clostridium difficile toxin B CROP domain in complex with FAB domains of neutralizing antibody bezlotoxumab

Summary for 4NP4

Entry DOI	10.2210/pdb4np4/pdb
Descriptor	Toxin B, bezlotoxumab heavy chain, bezlotoxumab light chain, ... (4 entities in total)
Functional Keywords	bezlotoxumab, human antibody, fab, crop domain, cytotoxin, short repeat, long repeat, tcdb, receptor binding, immune system
Biological source	Clostridium difficile More
Total number of polymer chains	5
Total formula weight	126218.78
Authors	Orth, P.,Xiao, L.,Hernandez, L.D.,Reichert, P.,Sheth, P.,Beaumont, M.,Murgolo, N.,Ermakov, G.,DiNunzio, E.,Racine, F.,Karczewski, J.,Secore, S.,Ingram, R.N.,Mayhood, T.,Strickland, C.,Therien, A.G. (deposition date: 2013-11-20, release date: 2014-05-21, Last modification date: 2023-09-20)
Primary citation	Orth, P.,Xiao, L.,Hernandez, L.D.,Reichert, P.,Sheth, P.R.,Beaumont, M.,Yang, X.,Murgolo, N.,Ermakov, G.,DiNunzio, E.,Racine, F.,Karczewski, J.,Secore, S.,Ingram, R.N.,Mayhood, T.,Strickland, C.,Therien, A.G. Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography. J.Biol.Chem., 289:18008-18021, 2014 Cited by PubMed: 24821719 DOI: 10.1074/jbc.M114.560748 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.89 Å)

Structure validation