4NP4
Clostridium difficile toxin B CROP domain in complex with FAB domains of neutralizing antibody bezlotoxumab
Summary for 4NP4
Entry DOI | 10.2210/pdb4np4/pdb |
Descriptor | Toxin B, bezlotoxumab heavy chain, bezlotoxumab light chain, ... (4 entities in total) |
Functional Keywords | bezlotoxumab, human antibody, fab, crop domain, cytotoxin, short repeat, long repeat, tcdb, receptor binding, immune system |
Biological source | Clostridium difficile More |
Total number of polymer chains | 5 |
Total formula weight | 126218.78 |
Authors | Orth, P.,Xiao, L.,Hernandez, L.D.,Reichert, P.,Sheth, P.,Beaumont, M.,Murgolo, N.,Ermakov, G.,DiNunzio, E.,Racine, F.,Karczewski, J.,Secore, S.,Ingram, R.N.,Mayhood, T.,Strickland, C.,Therien, A.G. (deposition date: 2013-11-20, release date: 2014-05-21, Last modification date: 2023-09-20) |
Primary citation | Orth, P.,Xiao, L.,Hernandez, L.D.,Reichert, P.,Sheth, P.R.,Beaumont, M.,Yang, X.,Murgolo, N.,Ermakov, G.,DiNunzio, E.,Racine, F.,Karczewski, J.,Secore, S.,Ingram, R.N.,Mayhood, T.,Strickland, C.,Therien, A.G. Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography. J.Biol.Chem., 289:18008-18021, 2014 Cited by PubMed: 24821719DOI: 10.1074/jbc.M114.560748 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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