4NP4

Clostridium difficile toxin B CROP domain in complex with FAB domains of neutralizing antibody bezlotoxumab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Toxin B	polymer	275	31657.4	1	UniProt (P18177) Pfam (PF01473) Pfam (PF19127)	Clostridium difficile
2	B, C (H, I)	bezlotoxumab heavy chain	polymer	222	23829.8	2		Homo sapiens (human)
3	D, E (L, M)	bezlotoxumab light chain	polymer	215	23450.9	2		Homo sapiens (human)
4	F, G, H, I (A, I, L, M)	water	water		18.0	13	Chemie (HOH)

Sequence modifications

A: 1834 - 2099 (UniProt: P18177)

PDB	External Database	Details
Met 1833	-	initiating methionine
Leu 2100	-	expression tag
Glu 2101	-	expression tag
His 2102	-	expression tag
His 2103	-	expression tag
His 2104	-	expression tag
His 2105	-	expression tag
His 2106	-	expression tag
His 2107	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	126218.8
All*	Total formula weight	126218.8

*Water molecules are not included.