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PDB: 188 件
4MM3
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BU of 4mm3 by Molmil
Crystal structure of SARS-CoV papain-like protease PLpro in complex with ubiquitin aldehyde
分子名称: Papain-like proteinase, Ubiquitin, ZINC ION
著者Mesecar, A.D, Ratia, K.
登録日2013-09-08
公開日2014-07-02
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.752 Å)
主引用文献Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.
Plos Pathog., 10, 2014
2BX4
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BU of 2bx4 by Molmil
Crystal Structure of SARS Coronavirus Main Proteinase (P21212)
分子名称: 3C-like proteinase nsp5
著者Verschueren, K.H.G, Mesters, J.R, Bigalke, J, Hilgenfeld, R.
登録日2005-07-22
公開日2005-09-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Ph-Dependent Conformational Flexibility of the Sars-Cov Main Proteinase (M(Pro)) Dimer: Molecular Dynamics Simulations and Multiple X-Ray Structure Analyses.
J.Mol.Biol., 354, 2005
2WCT
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BU of 2wct by Molmil
human SARS coronavirus unique domain (triclinic form)
分子名称: NON-STRUCTURAL PROTEIN 3
著者Tan, J, Vonrhein, C, Smart, O.S, Bricogne, G, Bollati, M, Hansen, G, Mesters, J.R, Hilgenfeld, R.
登録日2009-03-16
公開日2009-05-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献The Sars-Unique Domain (Sud) of Sars Coronavirus Contains Two Macrodomains that Bind G-Quadruplexes.
Plos Pathog., 5, 2009
2RHB
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BU of 2rhb by Molmil
Crystal structure of Nsp15-H234A mutant- Hexamer in asymmetric unit
分子名称: Uridylate-specific endoribonuclease
著者Palaninathan, S, Bhardwaj, K, Alcantara, J.M.O, Guarino, L, Yi, L.L, Kao, C.C, Sacchettini, J.
登録日2007-10-08
公開日2007-11-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15.
J.Biol.Chem., 283, 2008
6JYT
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BU of 6jyt by Molmil
Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis
分子名称: Helicase, ZINC ION
著者Yan, L, Jia, Z.
登録日2019-04-28
公開日2019-09-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis.
Nucleic Acids Res., 47, 2019
1UW7
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BU of 1uw7 by Molmil
Nsp9 protein from SARS-coronavirus.
分子名称: NSP9
著者Sutton, G, Fry, E, Carter, L, Sainsbury, S, Walter, T, Nettleship, J, Berrow, N, Owens, R, Gilbert, R, Davidson, A, Siddell, S, Poon, L.L.M, Diprose, J, Alderton, D, Walsh, M, Grimes, J.M, Stuart, D.I.
登録日2004-01-30
公開日2004-02-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The Nsp9 Replicase Protein of Sars-Coronavirus, Structure and Functional Insights
Structure, 12, 2004
1Z1J
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BU of 1z1j by Molmil
Crystal structure of SARS 3CLpro C145A mutant
分子名称: 3C-like proteinase
著者Hsu, M.F.
登録日2005-03-04
公開日2005-11-22
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Understanding the maturation process and inhibitor design of SARS-CoV 3CLpro from the crystal structure of C145A in a product-bound form
J.Biol.Chem., 280, 2005
1Z1I
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BU of 1z1i by Molmil
Crystal structure of native SARS CLpro
分子名称: 3C-like proteinase
著者Liang, P.H, Wang, A.H.
登録日2005-03-04
公開日2005-11-22
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Understanding the maturation process and inhibitor design of SARS-CoV 3CLpro from the crystal structure of C145A in a product-bound form
J.Biol.Chem., 280, 2005
5E6J
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BU of 5e6j by Molmil
Structure of SARS PLpro bound to a Lys48-linked di-ubiquitin activity based probe
分子名称: ACETATE ION, NICKEL (II) ION, Polyubiquitin-B, ...
著者Lima, C.D, Bekes, M.
登録日2015-10-09
公開日2016-05-18
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease.
Mol. Cell, 62, 2016
3M3T
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BU of 3m3t by Molmil
SARS-CoV main protease monomeric Arg298Ala mutant with N-terminal additional residues (Gly-Ser)
分子名称: 3C-like proteinase
著者Shi, J.H, Song, J.X.
登録日2010-03-10
公開日2011-03-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献SARS-CoV main protease with N-terminal extension regulated by mutation on C-terminal domain
To be Published
2OZK
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BU of 2ozk by Molmil
Structure of an N-Terminal Truncated Form of Nendou (NSP15) From SARS-CORONAVIRUS
分子名称: Uridylate-specific endoribonuclease
著者Saikatendu, K, Joseph, J, Subramanian, V, Neuman, B, Buchmeier, M, Stevens, R.C, Kuhn, P.
登録日2007-02-26
公開日2007-05-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch.
J.Virol., 81, 2007
3F9H
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BU of 3f9h by Molmil
Crystal Structure of the F140A mutant of SARS-Coronovirus 3C-like Protease at pH 7.6
分子名称: 3C-like proteinase
著者Hu, T, Li, L, Jiang, H, Shen, X.
登録日2008-11-13
公開日2009-09-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
3SNA
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BU of 3sna by Molmil
Crystal structure of SARS coronavirus main protease complexed with Ac-NSFSQ-H (soaking)
分子名称: 3C-like proteinase, Peptide aldehyde inhibitor Ac-NSFSQ-H
著者Zhu, L, Hilgenfeld, R.
登録日2011-06-29
公開日2011-09-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.
Antiviral Res., 92, 2011
6NUR
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BU of 6nur by Molmil
SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors
分子名称: NSP12, NSP7, NSP8, ...
著者Kirchdoerfer, R.N, Ward, A.B.
登録日2019-02-01
公開日2019-05-29
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors.
Nat Commun, 10, 2019
5C8T
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BU of 5c8t by Molmil
Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligand SAM
分子名称: Guanine-N7 methyltransferase, MAGNESIUM ION, Non-structural protein 10, ...
著者Ma, Y.Y, Wu, L.J, Zhang, R.G, Rao, Z.H.
登録日2015-06-26
公開日2015-07-15
最終更新日2015-08-12
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex
Proc.Natl.Acad.Sci.USA, 112, 2015
3IWM
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BU of 3iwm by Molmil
The octameric SARS-CoV main protease
分子名称: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
著者Zhong, N, Zhang, S, Xue, F, Lou, Z, Rao, Z, Xia, B.
登録日2009-09-02
公開日2010-07-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease
Protein Cell, 1, 2010
5C8S
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BU of 5c8s by Molmil
Crystal structure of the SARS coronavirus nsp14-nsp10 complex with functional ligands SAH and GpppA
分子名称: GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, Guanine-N7 methyltransferase, MAGNESIUM ION, ...
著者Ma, Y.Y, Wu, L.J, Zhang, R.G, Rao, Z.H.
登録日2015-06-26
公開日2015-07-15
最終更新日2015-08-12
実験手法X-RAY DIFFRACTION (3.326 Å)
主引用文献Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex
Proc.Natl.Acad.Sci.USA, 112, 2015
5NFY
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BU of 5nfy by Molmil
SARS-CoV nsp10/nsp14 dynamic complex
分子名称: DI(HYDROXYETHYL)ETHER, Polyprotein 1ab, ZINC ION
著者Ferron, F, Gluais, L, Vonrhein, C, Bricogne, G, Canard, B, Imbert, I.
登録日2017-03-16
公開日2018-01-10
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (3.382 Å)
主引用文献Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5C8U
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BU of 5c8u by Molmil
Crystal structure of the SARS coronavirus nsp14-nsp10 complex
分子名称: Guanine-N7 methyltransferase, MAGNESIUM ION, Non-structural protein 10, ...
著者Ma, Y.Y, Wu, L.J, Zhang, R.G, Rao, Z.H.
登録日2015-06-26
公開日2015-07-15
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.401 Å)
主引用文献Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex
Proc.Natl.Acad.Sci.USA, 112, 2015
6NUS
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BU of 6nus by Molmil
SARS-Coronavirus NSP12 bound to NSP8 co-factor
分子名称: NSP12, NSP8, ZINC ION
著者Kirchdoerfer, R.N, Ward, A.B.
登録日2019-02-01
公開日2019-05-29
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors.
Nat Commun, 10, 2019
6YXJ
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BU of 6yxj by Molmil
Crystal structure of SARS-CoV macrodomain II in complex with human Paip1
分子名称: Non-structural protein 3, Polyadenylate-binding protein-interacting protein 1
著者Lei, J, Hilgenfeld, R.
登録日2020-05-02
公開日2021-03-17
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.
Embo J., 40, 2021
7OPL
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BU of 7opl by Molmil
CryoEM structure of DNA Polymerase alpha - primase bound to SARS CoV nsp1
分子名称: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2021-06-01
公開日2021-11-10
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (4.12 Å)
主引用文献Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase.
Protein Sci., 31, 2022
2KYS
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NMR Structure of the SARS Coronavirus Nonstructural Protein Nsp7 in Solution at pH 6.5
分子名称: Non-structural protein 7
著者Johnson, M.A, Jaudzems, K, Wilson, I.A, Wuthrich, K, Joint Center for Structural Genomics (JCSG)
登録日2010-06-07
公開日2010-06-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR Structure of the SARS-CoV Nonstructural Protein 7 in Solution at pH 6.5.
J.Mol.Biol., 402, 2010
2K87
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NMR STRUCTURE OF A PUTATIVE RNA BINDING PROTEIN (SARS1) FROM SARS CORONAVIRUS
分子名称: Non-structural protein 3 of Replicase polyprotein 1a
著者Serrano, P, Wuthrich, K, Johnson, M.A, Chatterjee, A, Wilson, I, Pedrini, B.F, Joint Center for Structural Genomics (JCSG)
登録日2008-09-02
公開日2008-09-16
最終更新日2024-05-08
実験手法SOLUTION NMR
主引用文献Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3.
J.Virol., 83, 2009
2K7X
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solution structure of C-terminal domain of SARS-CoV main protease
分子名称: SARS-CoV main protease
著者Xia, B, Zhong, N.
登録日2008-08-28
公開日2009-05-12
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer.
Protein Sci., 18, 2009

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