6TC3
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6TBV
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7N2C
| Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2) | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | 登録日 | 2021-05-28 | 公開日 | 2021-07-14 | 最終更新日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
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7ZQ6
| 70S E. coli ribosome with truncated uL23 and uL24 loops and a stalled filamin domain 5 nascent chain | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Mitropoulou, A, Wlodarski, T, Ahn, M, Becker, T.A, Beckmann, R, Cabrita, L.D, Christodoulou, J. | 登録日 | 2022-04-29 | 公開日 | 2022-08-10 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Modulating co-translational protein folding by rational design and ribosome engineering. Nat Commun, 13, 2022
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8QK7
| E167K RF2 on E. coli 70S release complex with UAA | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Pundir, S, Larsson, D.S.D, Selmer, M, Sanyal, S. | 登録日 | 2023-09-14 | 公開日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | The compensatory mechanism of a naturally evolved
E167K RF2 counteracting the loss of
RF1 in bacteria To Be Published
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8P18
| E167K RF2 on E. coli 70S release complex with UGG (Structure III) | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Pundir, S, Larsson, D.S.D, Selmer, M, Sanyal, S. | 登録日 | 2023-05-11 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | The compensatory mechanism of a naturally evolved
E167K RF2 counteracting the loss of
RF1 in bacteria To Be Published
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8P16
| E167K RF2 on E. coli 70S release complex with UGG (Structure I) | 分子名称: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | 著者 | Pundir, S, Larsson, D.S.D, Selmer, M, Sanyal, S. | 登録日 | 2023-05-11 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | The compensatory mechanism of a naturally evolved
E167K RF2 counteracting the loss of
RF1 in bacteria To Be Published
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8P17
| E167K RF2 on E. coli 70S release complex with UGG (Structure II) | 分子名称: | 1,4-DIAMINOBUTANE, 16S RNA, 23S rRNA, ... | 著者 | Pundir, S, Larsson, D.S.D, Selmer, M, Sanyal, S. | 登録日 | 2023-05-11 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | The compensatory mechanism of a naturally evolved
E167K RF2 counteracting the loss of
RF1 in bacteria To Be Published
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8AM9
| Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the elongating ribosome | 分子名称: | 16S ribosomal RNA, 2-acetamido-2-deoxy-alpha-D-galactopyranose, 23S ribosomal RNA, ... | 著者 | Koller, T.O, Morici, M, Wilson, D.N. | 登録日 | 2022-08-03 | 公開日 | 2023-03-08 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for translation inhibition by the glycosylated drosocin peptide. Nat.Chem.Biol., 19, 2023
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7M5D
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4U26
| Crystal structure of the E. coli ribosome bound to dalfopristin and quinupristin. | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Noeske, J, Huang, J, Olivier, N.B, Giacobbe, R.A, Zambrowski, M, Cate, J.H.D. | 登録日 | 2014-07-16 | 公開日 | 2014-07-30 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Synergy of streptogramin antibiotics occurs independently of their effects on translation. Antimicrob.Agents Chemother., 58, 2014
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5J5B
| Structure of the WT E coli ribosome bound to tetracycline | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | 著者 | Cocozaki, A, Ferguson, A. | 登録日 | 2016-04-01 | 公開日 | 2016-07-27 | 最終更新日 | 2018-08-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proc.Natl.Acad.Sci.USA, 113, 2016
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4U27
| Crystal structure of the E. coli ribosome bound to flopristin and linopristin. | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Noeske, J, Huang, J, Olivier, N.B, Giacobbe, R.A, Zambrowski, M, Cate, J.H.D. | 登録日 | 2014-07-16 | 公開日 | 2014-07-30 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Synergy of streptogramin antibiotics occurs independently of their effects on translation. Antimicrob.Agents Chemother., 58, 2014
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8BHJ
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6QDW
| Cryo-EM structure of the 50S ribosomal subunit at 2.83 Angstroms with modeled GBC SecM peptide | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Schulte, L, Reitz, J, Hodirnau, V.V, Kudlinzki, D, Mao, J, Glaubitz, C, Frangakis, A, Schwalbe, H. | 登録日 | 2019-01-03 | 公開日 | 2020-01-15 | 最終更新日 | 2020-12-02 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Nat Commun, 11, 2020
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8BHN
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6Y69
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6U48
| E. coli 50S with phazolicin (PHZ) bound in exit tunnel | 分子名称: | 23S rRNA, 50S ribosomal protein bL17, 50S ribosomal protein bL19, ... | 著者 | Watson, Z.L, Cate, J.H.D, Polikanov, Y.S, Severinov, K. | 登録日 | 2019-08-23 | 公開日 | 2019-09-18 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition. Nat Commun, 10, 2019
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8BGH
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4V9O
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7OIZ
| Cryo-EM structure of 70S ribosome stalled with TnaC peptide | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Su, T, Kudva, R, Becker, T, Berninghausen, O, Heijne, G, Cheng, J, Beckmann, R. | 登録日 | 2021-05-13 | 公開日 | 2021-09-15 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide. Nucleic Acids Res., 49, 2021
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7P3K
| Cryo-EM structure of 70S ribosome stalled with TnaC peptide (control) | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Buschauer, R, Komar, T, Becker, T, Berninghausen, O, Cheng, J, Beckmann, R. | 登録日 | 2021-07-08 | 公開日 | 2021-10-27 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide. Nucleic Acids Res., 49, 2021
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4V9P
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7B5K
| E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain. | 分子名称: | 16S rRNA, 2-[[[(3~{R},5~{R})-3-azanyl-6-(3-azanylpropylamino)-5-oxidanyl-hexanoyl]amino]-methyl-amino]ethanoic acid, 23S rRNA, ... | 著者 | Albers, S, Beckert, B, Matthies, M, Schuster, R, Riedner, M, Seuring, C, Sanyal, S, Torda, A, Wilson, N.D, Ignatova, Z. | 登録日 | 2020-12-03 | 公開日 | 2021-05-26 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Harnessing evolutionarily flexibility in tRNAs to maximize nonsense suppression activities Nat Commun, 2021
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8SYL
| Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs | 分子名称: | (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S ,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | 著者 | Seely, S.M, Gagnon, M.G. | 登録日 | 2023-05-25 | 公開日 | 2023-08-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular basis of the pleiotropic effects by the antibiotic amikacin on the ribosome. Nat Commun, 14, 2023
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