6Y69

Cryo-EM structure of an Escherichia coli 70S ribosome in complex with antibiotic TetracenomycinX

This is a large structure.

Summary for 6Y69

EMDB information10705
Descriptor16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ... (56 entities in total)
Functional Keywordstetracenomycin, ribosome
Biological sourceEscherichia coli (strain K12)
Total number of polymer chains54
Total molecular weight2141149.23
Authors
Wieland, M.,Wilson, D.N. (deposition date: 2020-02-26, release date: 2020-07-01, Last modification date: 2020-07-08)
Primary citation
Osterman, I.A.,Wieland, M.,Maviza, T.P.,Lashkevich, K.A.,Lukianov, D.A.,Komarova, E.S.,Zakalyukina, Y.V.,Buschauer, R.,Shiriaev, D.I.,Leyn, S.A.,Zlamal, J.E.,Biryukov, M.V.,Skvortsov, D.A.,Tashlitsky, V.N.,Polshakov, V.I.,Cheng, J.,Polikanov, Y.S.,Bogdanov, A.A.,Osterman, A.L.,Dmitriev, S.E.,Beckmann, R.,Dontsova, O.A.,Wilson, D.N.,Sergiev, P.V.
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.
Nat.Chem.Biol., 2020
PubMed: 32601485 (PDB entries with the same primary citation)
DOI: 10.1038/s41589-020-0578-x
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone5 0.5% 1.9% 0.56MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload