8B0X
| Translating 70S ribosome in the unrotated state (P and E, tRNAs) | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Fromm, S.A, O'Connor, K.M, Purdy, M, Bhatt, P.R, Loughran, G, Atkins, J.F, Jomaa, A, Mattei, S. | 登録日 | 2022-09-08 | 公開日 | 2022-11-30 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (1.55 Å) | 主引用文献 | The translating bacterial ribosome at 1.55 angstrom resolution generated by cryo-EM imaging services. Nat Commun, 14, 2023
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8CGK
| Lincomycin and Avilamycin bound to the 50S subunit | 分子名称: | (2R,3S,4R,6S)-4-hydroxy-6-{[(2R,3aR,4R,4'R,5'S,6S,6'R,7aR)-4'-hydroxy-6-{[(2S,3R,4R,5S,6R)-3-hydroxy-2-{[(2R,3S,4S,5S,6S)-4-hydroxy-6-({(2R,3aS,3a'R,6S,6'R,7R,7'R,7aR,7a'R)-7'-hydroxy-7'-[(1S)-1-hydroxyethyl]-6'-methyl-7-[(2-methylpropanoyl)oxy]octahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl}oxy)-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl]oxy}-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl]oxy}-4,6',7a-trimethyloctahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-5'-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate (non-preferred name), 23S rRNA, 50S ribosomal protein L15, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | 登録日 | 2023-02-05 | 公開日 | 2023-07-19 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (1.64 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8CGV
| Tiamulin bound to the 50S subunit | 分子名称: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | 登録日 | 2023-02-06 | 公開日 | 2023-08-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (1.66 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8CEU
| Retapamulin and Capreomycin bound to the 50S subunit | 分子名称: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | 著者 | Paternoga, H, Beckert, B, Wilson, D.N. | 登録日 | 2023-02-02 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (1.83 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8FTO
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8CAM
| Evernimicin bound to the 50S subunit | 分子名称: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Novacek, J, Wilson, D.N. | 登録日 | 2023-01-24 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (1.86 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8AYE
| E. coli 70S ribosome bound to thermorubin and fMet-tRNA | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Sanyal, S, Parajuli, N.P, Emmerich, A.G. | 登録日 | 2022-09-02 | 公開日 | 2023-03-01 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (1.96 Å) | 主引用文献 | Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria. Nat Commun, 14, 2023
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8CGD
| Clindamycin bound to the 50S subunit | 分子名称: | 23S rRNA, 50S ribosomal protein L15, 50S ribosomal protein L25, ... | 著者 | Paternoga, H, Koller, T.O, Beckert, B, Wilson, D.N. | 登録日 | 2023-02-03 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (1.98 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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7K00
| Structure of the Bacterial Ribosome at 2 Angstrom Resolution | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Watson, Z.L, Ward, F.R, Meheust, R, Ad, O, Schepartz, A, Banfield, J.F, Cate, J.H.D. | 登録日 | 2020-09-02 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (1.98 Å) | 主引用文献 | Structure of the bacterial ribosome at 2 angstrom resolution. Elife, 9, 2020
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8QOA
| Structure of SecM-stalled Escherichia coli 70S ribosome | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S16, ... | 著者 | Gersteuer, F, Morici, M, Wilson, D.N. | 登録日 | 2023-09-28 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome. Nat Commun, 15, 2024
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8G6W
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8BIM
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8BIL
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8G6Y
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8EMM
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7QQ3
| Cryo-EM structure of the E.coli 50S ribosomal subunit in complex with the antibiotic Myxovalargin A. | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Koller, T.O, Beckert, B, Wilson, D.N. | 登録日 | 2022-01-06 | 公開日 | 2023-01-18 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition. J.Am.Chem.Soc., 145, 2023
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4YBB
| High-resolution structure of the Escherichia coli ribosome | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | 著者 | Noeske, J, Wasserman, M.R, Terry, D.S, Altman, R.B, Blanchard, S.C, Cate, J.H.D. | 登録日 | 2015-02-18 | 公開日 | 2015-03-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | High-resolution structure of the Escherichia coli ribosome. Nat.Struct.Mol.Biol., 22, 2015
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6XZ7
| E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet). | 分子名称: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | 著者 | Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L. | 登録日 | 2020-02-03 | 公開日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to theE. coli70S ribosome. Rna, 26, 2020
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8ANA
| Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the 50S ribosomal subunit | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Koller, T.O, Morici, M, Wilson, D.N. | 登録日 | 2022-08-05 | 公開日 | 2023-03-08 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | 主引用文献 | Structural basis for translation inhibition by the glycosylated drosocin peptide. Nat.Chem.Biol., 19, 2023
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8BGE
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8QBT
| E. coli ApdP-stalled ribosomal complex | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S11, ... | 著者 | Morici, M, Wilson, D.N. | 登録日 | 2023-08-25 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity. Nat Commun, 15, 2024
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8R6C
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6PJ6
| High resolution cryo-EM structure of E.coli 50S | 分子名称: | 23S rRNA, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | 著者 | Stojkovic, V, Myasnikov, A, Frost, A, Fujimori, D.G. | 登録日 | 2019-06-27 | 公開日 | 2020-01-22 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit. Nucleic Acids Res., 48, 2020
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7LVK
| Cfr-modified 50S subunit from Escherichia coli | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Stojkovic, V, Myasnikov, A.G, Frost, A, Fujimori, D.G. | 登録日 | 2021-02-25 | 公開日 | 2021-12-15 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Investigating antibiotic resistance of a ribosomal-RNA methylating enzyme through directed evolution To Be Published
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8BHL
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