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PDB: 84 件
4MMR
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BU of 4mmr by Molmil
Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 9.5
分子名称: Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2
著者Stewart-Jones, G.B.E, McLellan, J.S, Joyce, M.G, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D.
登録日2013-09-09
公開日2013-11-20
最終更新日2021-06-02
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
5TPN
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BU of 5tpn by Molmil
Crystal structure of RSV F in complex with human antibody hRSV90
分子名称: Fusion glycoprotein F0,Fibritin, hRSV0 light chain, hRSV90 heavy chain
著者Mousa, J.J, Crowe, J.E.
登録日2016-10-20
公開日2017-02-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.141 Å)
主引用文献Crystal structure of RSV F in complex with human antibody hRSV90
To Be Published
8KG5
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BU of 8kg5 by Molmil
Prefusion RSV F Bound to Lonafarnib and D25 Fab
分子名称: 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, D25 heavy chain, D25 light chain, ...
著者Yang, Q, Xue, B, Liu, F, Peng, W, Chen, X.
登録日2023-08-17
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein.
Signal Transduct Target Ther, 9, 2024
5C0R
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BU of 5c0r by Molmil
Crystal Structure of a Generation 3 Influenza Hemagglutinin Stabilized Stem Complexed with the Broadly Neutralizing Antibody C179
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C179 Fab heavy chain, ...
著者Boyington, J.C, kwong, P.D, Nabel, G.J, Mascola, J.R.
登録日2015-06-12
公開日2015-09-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.188 Å)
主引用文献Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection.
Nat. Med., 21, 2015
3RKI
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BU of 3rki by Molmil
Structural basis for immunization with post-fusion RSV F to elicit high neutralizing antibody titers
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0
著者Swanson, K.A, Settembre, E.C, Shaw, C.A, Dey, A.K, Rappuoli, R, Mandl, C.W, Dormitzer, P.D, Carfi, A.
登録日2011-04-18
公開日2011-05-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers.
Proc.Natl.Acad.Sci.USA, 108, 2011
6CRV
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BU of 6crv by Molmil
SARS Spike Glycoprotein, Stabilized variant, C3 symmetry
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ...
著者Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日2018-03-19
公開日2018-04-11
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
3RRT
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BU of 3rrt by Molmil
Structure of the RSV F protein in the post-fusion conformation
分子名称: Fusion glycoprotein F0
著者McLellan, J.S, Yongping, Y, Graham, B.S, Kwong, P.D.
登録日2011-04-30
公開日2011-06-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes.
J.Virol., 85, 2011
4MMQ
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BU of 4mmq by Molmil
Crystal Structure of Prefusion-stabilized RSV F Variant DS
分子名称: Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, SULFATE ION
著者Mclellan, J.S, Joyce, M.G, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D.
登録日2013-09-09
公開日2013-11-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.253 Å)
主引用文献Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
6OE4
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BU of 6oe4 by Molmil
Prefusion RSV F monomer bound by neutralizing antibody CR9501
分子名称: 1,2-ETHANEDIOL, CR9501 Fab Heavy Chain, CR9501 Fab Light Chain, ...
著者McLellan, J.S, Gilman, M.S.A.
登録日2019-03-27
公開日2019-04-17
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Transient opening of trimeric prefusion RSV F proteins.
Nat Commun, 10, 2019
5TOJ
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BU of 5toj by Molmil
Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Fibritin chimera, ...
著者Gilman, M.S.A, Kabeche, S.C, McLellan, J.S.
登録日2016-10-17
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nat Commun, 8, 2017
6CRZ
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BU of 6crz by Molmil
SARS Spike Glycoprotein, Trypsin-cleaved, Stabilized variant, C3 symmetry
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ...
著者Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日2018-03-19
公開日2018-04-11
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
6EAG
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BU of 6eag by Molmil
CRYSTAL STRUCTURE OF FUSION INHIBITOR JNJ-2408068 IN COMPLEX WITH HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN ESCAPE VARIANT G143S STABILIZED IN THE PREFUSION STATE
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[2-[[1-(2-azanylethyl)piperidin-4-yl]amino]-4-methyl-benzimidazol-1-yl]methyl]-6-methyl-pyridin-3-ol, D(-)-TARTARIC ACID, ...
著者Battles, M.B, McLellan, J.S.
登録日2018-08-03
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.302 Å)
主引用文献Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published
7MPG
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BU of 7mpg by Molmil
Cryo-EM structure of Prefusion-stabilized RSV F (DS-Cav1) in complex with Fab AM14
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab Heavy Chain, AM14 Fab Light Chain, ...
著者Abeyrathne, P.D, Malito, E, Harshbarger, W.D.
登録日2021-05-04
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.
Mabs, 13
6OUS
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BU of 6ous by Molmil
Structure of fusion glycoprotein from human respiratory syncytial virus
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, ...
著者Su, H.P.
登録日2019-05-05
公開日2019-10-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein.
Nat Commun, 10, 2019
5W23
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BU of 5w23 by Molmil
Crystal Structure of RSV F in complex with 5C4 Fab
分子名称: 5C4 Fab heavy chain, 5C4 Fab light chain, Fusion glycoprotein F0, ...
著者Battles, M.B, McLellan, J.S.
登録日2017-06-05
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.
Nat Commun, 8, 2017
5UDC
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BU of 5udc by Molmil
Crystal Structure of RSV F A2 Bound to MEDI8897
分子名称: CHLORIDE ION, Fusion glycoprotein F0, MEDI8897 Fab Heavy Chain, ...
著者McLellan, J.S.
登録日2016-12-26
公開日2017-05-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.
Sci Transl Med, 9, 2017
6DC5
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BU of 6dc5 by Molmil
RSV prefusion F in complex with AM22 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Jones, H.G, McLellan, J.S.
登録日2018-05-04
公開日2019-07-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Alternative conformations of a major antigenic site on RSV F.
Plos Pathog., 15, 2019
6DC3
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BU of 6dc3 by Molmil
RSV prefusion F bound to RSD5 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab RSD5-Germline Heavy Chain, Fab RSD5-Germline Light Chain, ...
著者Battles, M.B, McLellan, J.S, Jones, H.J.
登録日2018-05-04
公開日2019-07-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.501 Å)
主引用文献Alternative conformations of a major antigenic site on RSV F.
Plos Pathog., 15, 2019
7MMN
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BU of 7mmn by Molmil
Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab Heavy Chain, AM14 Fab Light Chain, ...
著者Harshbarger, W, Malito, E.
登録日2021-04-29
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.57 Å)
主引用文献Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.
Mabs, 13, 2021
5K6C
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BU of 5k6c by Molmil
Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 variant.
分子名称: Fusion glycoprotein F0,Fusion glycoprotein F0, SULFATE ION
著者Joyce, M.G, Zhang, B, Lai, Y.T, Mascola, J.R, Kwong, P.D.
登録日2016-05-24
公開日2016-10-12
最終更新日2016-10-19
実験手法X-RAY DIFFRACTION (3.576 Å)
主引用文献Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
Nat.Struct.Mol.Biol., 23, 2016
4JHW
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BU of 4jhw by Molmil
Crystal Structure of Respiratory Syncytial Virus Fusion Glycoprotein Stabilized in the Prefusion Conformation by Human Antibody D25
分子名称: D25 antigen-binding fragment heavy chain, D25 light chain, Fusion glycoprotein F0
著者Mclellan, J.S, Chen, M, Leung, S, Graepel, K.W, Du, X, Yang, Y, Zhou, T, Baxa, U, Yasuda, E, Beaumont, T, Kumar, A, Modjarrad, K, Zheng, Z, Zhao, M, Xia, N, Kwong, P.D, Graham, B.S.
登録日2013-03-05
公開日2013-05-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Science, 340, 2013
6W52
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BU of 6w52 by Molmil
Prefusion RSV F bound by neutralizing antibody RSB1
分子名称: Fusion glycoprotein F0, Fusion glycoprotein F1 fused with Fibritin trimerization domain, RSB1 Fab Heavy Chain, ...
著者Harshbarger, W, Chandramouli, S, Malito, M.
登録日2020-03-12
公開日2020-11-11
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.74 Å)
主引用文献Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F.
Plos Pathog., 16, 2020
5TOK
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BU of 5tok by Molmil
Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Fibritin chimera, ...
著者Gilman, M.S.A, Kabeche, S.C, McLellan, J.S.
登録日2016-10-17
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nat Commun, 8, 2017
6CS0
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BU of 6cs0 by Molmil
SARS Spike Glycoprotein, Trypsin-cleaved, Stabilized variant, one S1 CTD in an upwards conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ...
著者Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日2018-03-19
公開日2018-04-11
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
6CRX
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SARS Spike Glycoprotein, Stabilized variant, two S1 CTDs in the upwards conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ...
著者Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日2018-03-19
公開日2018-04-11
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018

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