5K6C

Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 variant.

Summary for 5K6C

• Entry DOI: 10.2210/pdb5k6c/pdb
• Related: 5K6B 5K6F 5K6G 5K6H 5K6I
• Descriptor: Fusion glycoprotein F0,Fusion glycoprotein F0, SULFATE ION (2 entities in total)
• Functional Keywords: respiratory syncytial virus, prefusion, vaccine, stabilized, viral protein
• Biological source: Human respiratory syncytial virus A (strain A2); More
• Cellular location: Virion membrane; Single-pass type I membrane protein: P03420
• Total number of polymer chains: 1
• Total formula weight: 49341.19

Authors

Joyce, M.G.,Zhang, B.,Lai, Y.T.,Mascola, J.R.,Kwong, P.D. (deposition date: 2016-05-24, release date: 2016-10-12, Last modification date: 2016-10-19)

• Primary citation: Joyce, M.G.,Zhang, B.,Ou, L.,Chen, M.,Chuang, G.Y.,Druz, A.,Kong, W.P.,Lai, Y.T.,Rundlet, E.J.,Tsybovsky, Y.,Yang, Y.,Georgiev, I.S.,Guttman, M.,Lees, C.R.,Pancera, M.,Sastry, M.,Soto, C.,Stewart-Jones, G.B.,Thomas, P.V.,Van Galen, J.G.,Baxa, U.,Lee, K.K.,Mascola, J.R.,Graham, B.S.,Kwong, P.D.; Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.; Nat.Struct.Mol.Biol., 23:811-820, 2016; PubMed: 27478931; DOI: 10.1038/nsmb.3267

Experimental method

X-RAY DIFFRACTION (3.576 Å)