7ZH4
 
 | | USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement) | | 分子名称: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ... | | 著者 | Rennie, M.L, Walden, H. | | 登録日 | 2022-04-05 | | 公開日 | 2022-10-12 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
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6DO5
 | | KLHDC2 ubiquitin ligase in complex with USP1 C-end degron | | 分子名称: | Kelch domain-containing protein 2, USP1 C-END DEGRON | | 著者 | Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N. | | 登録日 | 2018-06-08 | | 公開日 | 2018-12-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase.
Mol. Cell, 72, 2018
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7ZH3
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8A9J
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8A9K
 | | Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction) | | 分子名称: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, DNA (61-MER), Fanconi anemia group D2 protein, ... | | 著者 | Rennie, M.L, Walden, H. | | 登録日 | 2022-06-28 | | 公開日 | 2022-10-12 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
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7AY2
 | | Crystal structure of truncated USP1-UAF1 reacted with ubiquitin-prg | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ... | | 著者 | Arkinson, C, Rennie, M.L, Walden, H. | | 登録日 | 2020-11-10 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
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7AY0
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7AY1
 | | Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI | | 分子名称: | DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ... | | 著者 | Rennie, M.L, Arkinson, C, Walden, H. | | 登録日 | 2020-11-10 | | 公開日 | 2021-03-24 | | 最終更新日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
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