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PDB: 22 件

7ZUS
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Crystal structure of ternary complex of Pol theta polymerase domain
分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), DNA (5'-D(P*TP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), ...
著者Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A.
登録日2022-05-13
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
J.Med.Chem., 65, 2022
8E24
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BU of 8e24 by Molmil
Human DNA polymerase theta in complex with allosteric inhibitor
分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[2,4-bis(trifluoromethyl)phenyl]-N-phenyl-N-[3-(pyridazin-3-yl)prop-2-yn-1-yl]acetamide, DNA, ...
著者Mader, P, Pau, V.P.T, Sicheri, F.
登録日2022-08-13
公開日2022-09-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
J.Med.Chem., 65, 2022
8E23
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BU of 8e23 by Molmil
Human DNA polymerase theta in complex with allosteric inhibitor
分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*C*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ...
著者Mader, P, Pau, V.P.T, Sicheri, F.
登録日2022-08-13
公開日2022-09-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
J.Med.Chem., 65, 2022
7ZX1
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Crystal structure of Pol theta polymerase domain in complex with compound 22
分子名称: (2~{S},3~{R})-1-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]-~{N}-methyl-~{N}-(3-methylphenyl)-3-oxidanyl-pyrrolidine-2-carboxamide, 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ...
著者Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A.
登録日2022-05-19
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.829 Å)
主引用文献Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
J.Med.Chem., 65, 2022
5AGA
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BU of 5aga by Molmil
Crystal structure of the Helicase domain of human DNA polymerase theta in complex with AMPPNP
分子名称: CITRATE ANION, DNA POLYMERASE THETA, MAGNESIUM ION, ...
著者Newman, J.A, Cooper, C.D.O, Aitkenhead, H, Pinkas, D.M, Kupinska, K, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
登録日2015-01-29
公開日2015-02-25
最終更新日2015-12-16
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
7ZX0
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Crystal structure of Pol theta polymerase domain in complex with compound 5
分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[5-bromanyl-3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]oxy-~{N}-ethyl-~{N}-(3-methylphenyl)ethanamide, DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*(DDG))-3'), ...
著者Krajewski, W.W, Turnbull, A.P, Willis, S, Charles, M, Stockley, M, Heald, R.A.
登録日2022-05-19
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
J.Med.Chem., 65, 2022
9C5Q
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BU of 9c5q by Molmil
Human DNA polymerase theta helicase domain in microhomology annealed state 2, dimer form
分子名称: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*CP*CP*CP*GP*GP*G)-3'), DNA polymerase theta
著者Ito, F, Li, Z, Chen, X.S.
登録日2024-06-06
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
8W0A
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BU of 8w0a by Molmil
Human DNA polymerase theta helicase domain in complex with ssDNA, dimer form
分子名称: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*T)-3'), DNA polymerase theta
著者Ito, F, Li, Z, Chen, X.S.
登録日2024-02-13
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
5A9F
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BU of 5a9f by Molmil
Crystal structure of the Helicase domain of human DNA polymerase theta in complex with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA POLYMERASE THETA, MAGNESIUM ION, ...
著者Newman, J.A, Cooper, C.D.O, Aitkenhead, H, Pinkas, D.M, Kupinska, K, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
登録日2015-07-21
公開日2015-12-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
8GD7
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BU of 8gd7 by Molmil
Loop Deleted DNA Polymerase Theta Polymerase Domain in Complex with Double Strand DNA Overhang and Inhibitor
分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-(3-methyl-2-oxoimidazolidin-1-yl)-4,6-bis(trifluoromethyl)phenyl (4-fluorophenyl)methylcarbamate, DNA Primer, ...
著者Fried, W.A, Chen, X.S, Li, S.X.
登録日2023-03-03
公開日2024-06-19
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Discovery of a small-molecule inhibitor that traps Pol theta on DNA and synergizes with PARP inhibitors.
Nat Commun, 15, 2024
6XBU
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BU of 6xbu by Molmil
polymerase domain of polymerase-theta
分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*TP*CP*AP*TP*TP*G)-3'), DNA polymerase theta, ...
著者Chen, X, Pomerantz, R, Zhao, J.
登録日2020-06-07
公開日2021-06-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献Pol theta reverse transcribes RNA and promotes RNA-templated DNA repair.
Sci Adv, 7, 2021
9BH6
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BU of 9bh6 by Molmil
Human DNA polymerase theta helicase domain tetramer in the apo form
分子名称: DNA polymerase theta
著者Zerio, C.J, Lander, G.C.
登録日2024-04-19
公開日2024-05-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Human polymerase theta helicase positions DNA microhomologies for double-strand break repair
To Be Published
9BH7
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BU of 9bh7 by Molmil
Human DNA polymerase theta helicase domain dimer in the apo form
分子名称: DNA polymerase theta
著者Zerio, C.J, Lander, G.C.
登録日2024-04-19
公開日2024-05-01
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Human polymerase theta helicase positions DNA microhomologies for double-strand break repair
To Be Published
9BHA
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BU of 9bha by Molmil
Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology annealed conformation
分子名称: DNA polymerase theta, Stem-loop DNA with microhomology in the 3' overhang
著者Zerio, C.J, Lander, G.C.
登録日2024-04-19
公開日2024-05-01
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Human polymerase theta helicase positions DNA microhomologies for double-strand break repair
To Be Published
9ASL
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BU of 9asl by Molmil
Human DNA polymerase theta helicase domain tetramer, apo-form
分子名称: DNA polymerase theta
著者Ito, F, Li, Z, Chen, X.S.
登録日2024-02-26
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
9ASJ
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BU of 9asj by Molmil
Human DNA polymerase theta helicase domain in complex with AMP-PNP, dimer form
分子名称: DNA polymerase theta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Ito, F, Li, Z, Chen, X.S.
登録日2024-02-26
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
9BH9
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BU of 9bh9 by Molmil
Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology aligning conformation
分子名称: DNA polymerase theta, Stem-loop DNA with microhomology in the 3' overhang
著者Zerio, C.J, Lander, G.C.
登録日2024-04-19
公開日2024-05-01
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Human polymerase theta helicase positions DNA microhomologies for double-strand break repair
To Be Published
5A9J
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BU of 5a9j by Molmil
Crystal structure of the Helicase domain of human DNA polymerase theta, apo-form
分子名称: DNA POLYMERASE THETA
著者Newman, J.A, Cooper, C.D.O, Aitkenhead, H, Pinkas, D.M, Kupinska, K, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
登録日2015-07-21
公開日2015-12-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
9BH8
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BU of 9bh8 by Molmil
Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology searching conformation
分子名称: DNA polymerase theta, Stem-loop DNA with microhomology in the 3' overhang
著者Zerio, C.J, Lander, G.C.
登録日2024-04-19
公開日2024-05-01
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Human polymerase theta helicase positions DNA microhomologies for double-strand break repair
To Be Published
9ASK
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BU of 9ask by Molmil
Human DNA polymerase theta helicase domain dimer, apo-form
分子名称: DNA polymerase theta
著者Ito, F, Li, Z, Chen, X.S.
登録日2024-02-26
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
4X0Q
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BU of 4x0q by Molmil
Ternary complex of human DNA polymerase theta C-terminal domain binding ddGTP opposite dCMP
分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ...
著者Zahn, K.E, Doublie, S.
登録日2014-11-22
公開日2015-03-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Human DNA polymerase theta grasps the primer terminus to mediate DNA repair.
Nat.Struct.Mol.Biol., 22, 2015
4X0P
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Ternary complex of human DNA polymerase theta C-terminal domain binding ddATP opposite a tetrahydrofuran AP site analog
分子名称: 2',3'-dideoxyadenosine triphosphate, CALCIUM ION, DNA (5'-D(*CP*GP*TP*TP*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), ...
著者Zahn, K.E, Doublie, S.
登録日2014-11-21
公開日2015-03-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.911 Å)
主引用文献Human DNA polymerase theta grasps the primer terminus to mediate DNA repair.
Nat.Struct.Mol.Biol., 22, 2015

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件を2024-06-26に公開中

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