6FMC
 
 | | Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure | | 分子名称: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1 | | 著者 | Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P. | | 登録日 | 2018-01-30 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | | 主引用文献 | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
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6TKK
 | | Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide | | 分子名称: | 1,2-ETHANEDIOL, ACE-ARG-PRO-GLN-PRO-ARG, Neuropilin-1 | | 著者 | Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S. | | 登録日 | 2019-11-28 | | 公開日 | 2020-12-16 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | | 主引用文献 | Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide
To Be Published
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8PFE
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5JGI
 | | X-ray structure of neuropilin-1 b1 domain complexed with M45 compound | | 分子名称: | N-ALPHA-L-ACETYL-ARGININE, Neuropilin-1 | | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | | 登録日 | 2016-04-20 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
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5C7G
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5IJR
 | | X-ray structure of neuropilin-1 b1 domain complexed with Arg-1 ligand. | | 分子名称: | DIMETHYL SULFOXIDE, L-HOMOARGININE, Neuropilin-1 | | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | | 登録日 | 2016-03-02 | | 公開日 | 2017-03-29 | | 最終更新日 | 2018-07-11 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
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9EOU
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7O1N
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7P5U
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5JGQ
 | | X-ray structure of neuropilin-1 b1 domain complexed with Arg-7 ligand. | | 分子名称: | DIMETHYL SULFOXIDE, Neuropilin-1, N~2~-(benzenecarbonyl)-L-arginine | | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | | 登録日 | 2016-04-20 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
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5IYY
 | | X-ray structure of neuropilin-1 b1 domain complexed with Arg-4 ligand. | | 分子名称: | Neuropilin-1, N~2~-[(benzyloxy)carbonyl]-L-arginine | | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | | 登録日 | 2016-03-24 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
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4RN5
 | | B1 domain of human Neuropilin-1 with acetate ion in a ligand-binding site | | 分子名称: | ACETATE ION, GLYCEROL, Neuropilin-1, ... | | 著者 | Allerston, C.K, Yelland, T.S, Jarvis, A, Jenkins, K, Winfield, N, Cheng, L, Jia, H, Zachary, I, Selwood, D.L, Djordjevic, S. | | 登録日 | 2014-10-23 | | 公開日 | 2015-10-28 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Conserved water molecules in a ligand-binding site of neuropilin-1
To be Published
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5JHK
 | | X-ray structure of neuropilin-1 b1 domain complexed with Arg-6 ligand. | | 分子名称: | N-(benzenecarbonyl)glycyl-L-arginine, Neuropilin-1 | | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | | 登録日 | 2016-04-21 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
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2QQI
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1KEX
 | | Crystal Structure of the b1 Domain of Human Neuropilin-1 | | 分子名称: | Neuropilin-1 | | 著者 | Lee, C.C, Kreusch, A, McMullan, D, Ng, K, Spraggon, G. | | 登録日 | 2001-11-18 | | 公開日 | 2003-01-28 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of the Human Neuropilin-1 b1 Domain
Structure, 11, 2003
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2QQM
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5J1X
 | | X-ray structure of neuropilin-1 b1 domain complexed with Arg-5 ligand. | | 分子名称: | DIMETHYL SULFOXIDE, Neuropilin-1, N~2~-(tert-butoxycarbonyl)-L-arginine | | 著者 | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | | 登録日 | 2016-03-29 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
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2QQN
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5L73
 | | MAM domain of human neuropilin-1 | | 分子名称: | BICINE, CALCIUM ION, Neuropilin-1, ... | | 著者 | Yelland, T, Djordjevic, S. | | 登録日 | 2016-06-01 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture.
Structure, 24, 2016
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7JJC
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4DEQ
 | | Structure of the Neuropilin-1/VEGF-A complex | | 分子名称: | Neuropilin-1, Vascular endothelial growth factor A, PHOSPHATE ION | | 著者 | Vander Kooi, C.W. | | 登録日 | 2012-01-21 | | 公開日 | 2012-02-08 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.649 Å) | | 主引用文献 | Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1.
J.Biol.Chem., 287, 2012
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8C5G
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6FMF
 | | Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure | | 分子名称: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1, trifluoroacetic acid | | 著者 | Yelland, T, Djordjevic, S, Selwood, D, Zachary, I, Frankel, P. | | 登録日 | 2018-01-31 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.811 Å) | | 主引用文献 | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
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3I97
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