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PDB: 226 件
6BB4
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BU of 6bb4 by Molmil
Fab/epitope complex of mouse monoclonal antibody C5.2 targeting a phospho-tau epitope.
分子名称: Microtubule-associated protein tau, Mouse monoclonal antibody C5.2 Fab heavy chain, Mouse monoclonal antibody C5.2 Fab light chain, ...
著者Chukwu, J.E, Kong, X.-P.
登録日2017-10-16
公開日2018-05-02
最終更新日2019-12-18
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein.
Sci Rep, 8, 2018
8OTG
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BU of 8otg by Molmil
CTE typeI tau filament from Kii ALS/PDC
分子名称: Microtubule-associated protein tau
著者Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
登録日2023-04-20
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
8Q8R
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BU of 8q8r by Molmil
Tau - AD-PHF
分子名称: Isoform Tau-D of Microtubule-associated protein tau
著者Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M.
登録日2023-08-18
公開日2023-09-20
最終更新日2024-01-17
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献Disease-specific tau filaments assemble via polymorphic intermediates.
Nature, 625, 2024
8Q9H
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BU of 8q9h by Molmil
Tau - CTE-LIA4 (tau intermediate amyloid)
分子名称: Isoform Tau-D of Microtubule-associated protein tau
著者Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M.
登録日2023-08-20
公開日2023-09-20
最終更新日2024-01-17
実験手法ELECTRON MICROSCOPY (2.18 Å)
主引用文献Disease-specific tau filaments assemble via polymorphic intermediates.
Nature, 625, 2024
7P6B
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BU of 7p6b by Molmil
Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
8Q2L
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BU of 8q2l by Molmil
Tau - AD-MIA4
分子名称: Isoform Tau-D of Microtubule-associated protein tau
著者Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M.
登録日2023-08-02
公開日2023-09-20
最終更新日2024-01-24
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Disease-specific tau filaments assemble via polymorphic intermediates.
Nature, 625, 2024
8Q2J
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BU of 8q2j by Molmil
Tau - AD-MIA2
分子名称: Isoform Tau-D of Microtubule-associated protein tau
著者Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M.
登録日2023-08-02
公開日2023-08-30
最終更新日2024-01-24
実験手法ELECTRON MICROSCOPY (2.23 Å)
主引用文献Disease-specific tau filaments assemble via polymorphic intermediates.
Nature, 625, 2024
7QK6
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BU of 7qk6 by Molmil
In vitro assembled 258-391 tau filaments with heparan sulfate, 700 rpm (40a)
分子名称: Microtubule-associated protein tau
著者Lovestam, S, Scheres, S.H.W.
登録日2021-12-17
公開日2022-02-16
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (2.27 Å)
主引用文献Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy.
Elife, 11, 2022
8CAQ
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BU of 8caq by Molmil
Structure of Tau filaments Type I from Subacute Sclerosing Panencephalitis
分子名称: Microtubule-associated protein tau
著者Qi, C, Hasegawa, M, Takao, M, Sakai, M, Akagi, M, Iwasaki, Y, Yoshida, M, Scheres, S.H.W, Goedert, M.
登録日2023-01-24
公開日2023-11-08
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy.
Acta Neuropathol Commun, 11, 2023
9EOE
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BU of 9eoe by Molmil
PHF type tau filament from V337M mutant
分子名称: Isoform Tau-F of Microtubule-associated protein tau
著者Qi, C, Scheres, S.H.W, Michel, G.
登録日2024-03-14
公開日2024-07-10
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W.
Biorxiv, 2024
6NWP
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BU of 6nwp by Molmil
Chronic traumatic encephalopathy Type I Tau filament
分子名称: Microtubule-associated protein tau
著者Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W.
登録日2019-02-07
公開日2019-03-27
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Nature, 568, 2019
9ERM
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CTE type I tau filament from vacuolar tauopathy
分子名称: Microtubule-associated protein tau
著者Qi, C, Scheres, H.W.S, Goedert, M.
登録日2024-03-24
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G.
Acta Neuropathol, 147, 2024
8ORG
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BU of 8org by Molmil
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II)
分子名称: Microtubule-associated protein tau
著者Lovestam, S, Scheres, S.H.W, Goedert, M.
登録日2023-04-13
公開日2023-04-26
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.
Febs Open Bio, 13, 2023
5MP5
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BU of 5mp5 by Molmil
Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5
分子名称: Microtubule-associated protein tau, antibody Fab heavy chain, antibody Fab light chain
著者Skrabana, R, Novak, M.
登録日2016-12-15
公開日2018-05-02
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Crystal structure of DC8E8 Fab in the complex with a 14-mer tau peptide at pH 6.5
To be published
7QKW
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BU of 7qkw by Molmil
In vitro assembled 266-391 S356D tau filaments with KCl (44a)
分子名称: Microtubule-associated protein tau
著者Lovestam, S, Scheres, S.H.W.
登録日2021-12-19
公開日2022-02-16
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (2.32 Å)
主引用文献Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy.
Elife, 11, 2022
8PII
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BU of 8pii by Molmil
VHH Z70 mutant 3 in interaction with PHF6 Tau peptide
分子名称: Microtubule-associated protein tau, VHH Z70 Mutant 3
著者Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I.
登録日2023-06-21
公開日2023-07-05
最終更新日2024-04-24
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
8TTN
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BU of 8ttn by Molmil
PHF1-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S396E, S400E, T403E, S404E)
分子名称: Microtubule-associated protein tau
著者El Mammeri, N, Dregni, A.J, Duan, P, Hong, M.
登録日2023-08-14
公開日2024-06-26
実験手法ELECTRON MICROSCOPY (2.4 Å)
主引用文献Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation.
Proc.Natl.Acad.Sci.USA, 121, 2024
7QK3
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BU of 7qk3 by Molmil
In vitro assembled 258-391 tau filaments, 700 rpm (38a)
分子名称: Microtubule-associated protein tau
著者Lovestam, S, Scheres, S.H.W.
登録日2021-12-17
公開日2022-02-16
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (2.44 Å)
主引用文献Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy.
Elife, 11, 2022
7EYC
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BU of 7eyc by Molmil
Crystal structure of Tau and acetylated tau peptide antigen
分子名称: ACETYLATED TAU PEPTIDE, antibody, Heavy chain, ...
著者Hong, M, Park, J.
登録日2021-05-30
公開日2022-06-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models.
J.Clin.Invest., 133, 2023
9ERN
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BU of 9ern by Molmil
CTE type II tau filament from vacuolar tauopathy
分子名称: Microtubule-associated protein tau
著者Qi, C, Scheres, H.W.S, Goedert, M.
登録日2024-03-24
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G.
Acta Neuropathol, 147, 2024
5DMG
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BU of 5dmg by Molmil
X-RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416-430)
分子名称: Microtubule-associated protein, RB86 antibody Fab fragment heavy chain, RB86 antibody Fab fragment light chain
著者Benz, J, Lorenz, S, Georges, G, Jochner, A, Goepfert, U, Grueninger, F, Bujotzek, A.
登録日2015-09-08
公開日2015-12-16
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献VH-VL orientation prediction for antibody humanization candidate selection: A case study.
Mabs, 8, 2016
7P6C
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BU of 7p6c by Molmil
Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament
分子名称: Microtubule-associated protein tau
著者Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W.
登録日2021-07-15
公開日2021-09-15
最終更新日2021-10-27
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Structure-based classification of tauopathies.
Nature, 598, 2021
7YPG
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BU of 7ypg by Molmil
Cryo-EM structure of amyloid fibril formed by tau (297-391)
分子名称: Isoform Tau-E of Microtubule-associated protein tau
著者Zhang, S.Q, Li, X, Liu, C.
登録日2022-08-03
公開日2022-12-14
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure.
Iscience, 25, 2022
9BBL
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BU of 9bbl by Molmil
THF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition
分子名称: Isoform Tau-F of Microtubule-associated protein tau
著者Duan, P, El Mammeri, N.
登録日2024-04-06
公開日2024-05-08
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Milligram-scale assembly and NMR fingerprint of tau fibrils adopting the Alzheimer's disease fold.
J.Biol.Chem., 300, 2024
8ORF
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BU of 8orf by Molmil
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts
分子名称: Microtubule-associated protein tau
著者Lovestam, S, Scheres, S.H.W, Goedert, M.
登録日2023-04-13
公開日2023-04-26
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.
Febs Open Bio, 13, 2023

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