Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 63 件
5IL2
DownloadVisualize
BU of 5il2 by Molmil
Crystal structure of SAH-bound METTL3-METTL14 complex
分子名称: 1,2-ETHANEDIOL, METTL14, METTL3, ...
著者Wang, X, Guan, Z, Zou, T, Yin, P.
登録日2016-03-04
公開日2016-05-25
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (1.606 Å)
主引用文献Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
7RX7
DownloadVisualize
BU of 7rx7 by Molmil
Structure of METTL3-METTL14(R298P) mutant methyltransferase complex
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase non-catalytic subunit
著者Wang, P, Nam, Y.
登録日2021-08-21
公開日2022-11-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.645 Å)
主引用文献Structure of METTL3-METTL14(R298P) mutant methyltransferase complex
To Be Published
5K7W
DownloadVisualize
BU of 5k7w by Molmil
Crystal structure of the catalytic domain of Mettl3/Mettl14 complex with SAH
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYL-L-HOMOCYSTEINE
著者Wang, P, Doxtader, K.A, Nam, Y.
登録日2016-05-26
公開日2016-07-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5K7M
DownloadVisualize
BU of 5k7m by Molmil
Crystal structure of the catalytic domains of Mettl3/Mettl14 complex
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14
著者Wang, P, Doxtader, K.A, Nam, Y.
登録日2016-05-26
公開日2016-07-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5K7U
DownloadVisualize
BU of 5k7u by Molmil
Crystal structure of the catalytic domains of Mettl3/Mettl14 complex with SAM
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYLMETHIONINE
著者Wang, P, Doxtader, K.A, Nam, Y.
登録日2016-05-26
公開日2016-07-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5IL1
DownloadVisualize
BU of 5il1 by Molmil
Crystal structure of SAM-bound METTL3-METTL14 complex
分子名称: 1,2-ETHANEDIOL, METTL14, METTL3, ...
著者Wang, X, Guan, Z, Zou, T, Yin, P.
登録日2016-03-04
公開日2016-05-25
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
7RX6
DownloadVisualize
BU of 7rx6 by Molmil
Structure of METTL3-METTL14(R298C) mutant methyltransferase complex
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase non-catalytic subunit
著者Wang, P, Nam, Y.
登録日2021-08-21
公開日2022-11-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of METTL3-METTL14(R298C) mutant methyltransferase complex
To Be Published
7O09
DownloadVisualize
BU of 7o09 by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 7 (ADO_AC_074)
分子名称: 6-[4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]-N-(phenylmethyl)pyrimidin-4-amine, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Dolbois, A, Caflisch, A.
登録日2021-03-25
公開日2021-09-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.
J.Med.Chem., 64, 2021
5TEY
DownloadVisualize
BU of 5tey by Molmil
Human METTL3-METTL14 complex
分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ...
著者DONG, A, ZENG, H, LI, Y, TEMPEL, W, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
登録日2016-09-23
公開日2016-11-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Human METTL3-METTL14 complex
to be published
7RX8
DownloadVisualize
BU of 7rx8 by Molmil
Structure of METTL3-METTL14(R298H) mutant methyltransferase complex
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase non-catalytic subunit
著者Wang, P, Nam, Y.
登録日2021-08-21
公開日2022-11-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of METTL3-METTL14(R298H) mutant methyltransferase complex
To Be Published
7NHI
DownloadVisualize
BU of 7nhi by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ004
分子名称: (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl)piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-02-10
公開日2021-09-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
5L6D
DownloadVisualize
BU of 5l6d by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to SAH
分子名称: ACETATE ION, MAGNESIUM ION, N6-adenosine-methyltransferase 70 kDa subunit, ...
著者Sledz, P, Jinek, M.
登録日2016-05-29
公開日2016-10-12
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Structural insights into the molecular mechanism of the m(6)A writer complex.
Elife, 5, 2016
7OEL
DownloadVisualize
BU of 7oel by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ097
分子名称: ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-05-03
公開日2021-10-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
5IL0
DownloadVisualize
BU of 5il0 by Molmil
Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation
分子名称: 1,2-ETHANEDIOL, BROMIDE ION, METTL14, ...
著者Wang, X, Guan, Z, Zou, T, Yin, P.
登録日2016-03-04
公開日2016-05-25
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (1.882 Å)
主引用文献Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
6Y4G
DownloadVisualize
BU of 6y4g by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Sinefungin
分子名称: ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ...
著者Bedi, R.K, Omori, E, Caflisch, A.
登録日2020-02-20
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
7O0L
DownloadVisualize
BU of 7o0l by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ADO_AC_093)
分子名称: 4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Dolbois, A, Caflisch, A.
登録日2021-03-26
公開日2021-09-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.
J.Med.Chem., 64, 2021
7OEK
DownloadVisualize
BU of 7oek by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ091
分子名称: 4-[[(3S)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-2-oxidanyl-N-[[(3R)-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-05-03
公開日2021-10-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
5L6E
DownloadVisualize
BU of 5l6e by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to SAM
分子名称: ACETATE ION, MAGNESIUM ION, N6-adenosine-methyltransferase 70 kDa subunit, ...
著者Sledz, P, Jinek, M.
登録日2016-05-29
公開日2016-10-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Structural insights into the molecular mechanism of the m(6)A writer complex.
Elife, 5, 2016
7NHV
DownloadVisualize
BU of 7nhv by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ016
分子名称: (R)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-((4,4-dimethylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-02-11
公開日2021-10-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
6TTX
DownloadVisualize
BU of 6ttx by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ASI_M3M_051)
分子名称: (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-(piperidin-4-ylmethyl)oxolane-2-carboxamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Sledz, P, Caflisch, A.
登録日2019-12-30
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
6TTP
DownloadVisualize
BU of 6ttp by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 1/Adenosine (DHU_M3M_023)
分子名称: ACETATE ION, ADENOSINE, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Sledz, P, Caflisch, A.
登録日2019-12-30
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
7OQP
DownloadVisualize
BU of 7oqp by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ113
分子名称: ACETATE ION, N-[[(3R)-1-[6-(1-benzothiophen-4-ylmethylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-06-03
公開日2021-10-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
7O08
DownloadVisualize
BU of 7o08 by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ADO_AB_075)
分子名称: 4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-4-ol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Dolbois, A, Caflisch, A.
登録日2021-03-25
公開日2021-09-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.
J.Med.Chem., 64, 2021
7OED
DownloadVisualize
BU of 7oed by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ019a
分子名称: 4-[(4,4-dimethylpiperidin-1-yl)methyl]-~{N}-[[(3~{R})-1-[6-(methylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-05-03
公開日2021-10-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
7OEH
DownloadVisualize
BU of 7oeh by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ059b
分子名称: 4-[[(3S)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-N-[[(3S)-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-05-03
公開日2021-10-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023

 

123>

222415

件を2024-07-10に公開中

PDB statisticsPDBj update infoContact PDBjnumon