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PDB: 1846 件
7BNM
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Closed conformation of D614G SARS-CoV-2 spike protein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Benton, D.J, Wrobel, A.G, Rosenthal, P.B, Gamblin, S.J.
登録日2021-01-22
公開日2021-02-03
最終更新日2021-03-10
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 118, 2021
7Z9Q
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CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-A10 nanobody complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody H11-A10, ...
著者Weckener, M, Naismith, J.H.
登録日2022-03-21
公開日2022-07-13
最終更新日2022-10-05
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Proc.Natl.Acad.Sci.USA, 119, 2022
7W98
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SARS-CoV-2 Delta S-ACE2-C1
分子名称: Angiotensin-converting enzyme 2, Spike glycoprotein
著者Cong, Y, Liu, C.X.
登録日2021-12-09
公開日2022-01-12
最終更新日2022-03-02
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies.
Nat Commun, 13, 2022
7W9F
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BU of 7w9f by Molmil
SARS-CoV-2 Delta S-RBD-8D3
分子名称: Spike protein S1, The heavy chain of 8D3, The light chain of 8D3
著者Cong, Y, Liu, C.X.
登録日2021-12-09
公開日2022-01-12
最終更新日2022-03-02
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies.
Nat Commun, 13, 2022
7R13
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Alpha Variant SARS-CoV-2 Spike in Closed conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Benton, D.J, Wrobel, A.G, Gamblin, S.J.
登録日2022-02-02
公開日2022-03-09
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Evolution of the SARS-CoV-2 spike protein in the human host.
Nat Commun, 13, 2022
7CWM
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Complex of SARS-CoV-2 spike protein and Fab P17 with one RBD in open state and two RBD in closed state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P17 heavy chain, ...
著者Wang, N, Wang, X.
登録日2020-08-29
公開日2020-12-16
最終更新日2021-01-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection.
Cell Res., 31, 2021
7VHK
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S1-S2 deletion S-2P trimer(3 down)
分子名称: Spike glycoprotein
著者Wang, X, Cui, Z.
登録日2021-09-22
公開日2022-10-19
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Furin Site deletion S-2P trimer
To Be Published
7KJ2
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SARS-CoV-2 Spike Glycoprotein with one ACE2 Bound
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者Zhang, J, Xiao, T.S, Cai, Y.F, Chen, B.
登録日2020-10-25
公開日2020-11-11
最終更新日2021-02-24
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent.
Nat.Struct.Mol.Biol., 28, 2021
7KJ5
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SARS-CoV-2 Spike Glycoprotein, prefusion with one RBD up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhang, J, Xiao, T.S, Cai, Y.F, Chen, B.
登録日2020-10-25
公開日2020-11-11
最終更新日2021-02-24
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent.
Nat.Struct.Mol.Biol., 28, 2021
7VND
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BU of 7vnd by Molmil
Structure of the SARS-CoV-2 spike glycoprotein in complex with a human single domain antibody n3113 (UUD-state, state 2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Yang, Z, Wang, Y, Kong, Y, Jin, Y, Wu, Y, Ying, T.
登録日2021-10-10
公開日2021-11-24
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants.
Signal Transduct Target Ther, 6, 2021
7VXF
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SARS-CoV-2 spike protein in complex with ACE2, Beta variant, C2B state
分子名称: Angiotensin-converting enzyme 2, Spike glycoprotein
著者Xu, C, Cong, Y.
登録日2021-11-12
公開日2021-12-01
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM.
Nat Commun, 12, 2021
7N4L
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BU of 7n4l by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2125.
分子名称: Spike protein S1, WRAIR-2125 antibody Fab heavy chain, WRAIR-2125 antibody Fab light chain
著者Sankhala, R.S, Joyce, M.G.
登録日2021-06-04
公開日2021-11-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.601 Å)
主引用文献Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations.
Nat.Immunol., 22, 2021
7WK8
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BU of 7wk8 by Molmil
SARS-CoV-2 Omicron spike protein SD1 in complex with S3H3 Fab
分子名称: Heavy chain of S3H3 Fab, Light chain of S3H3 Fab, Spike glycoprotein
著者Hong, Q, Cong, Y.
登録日2022-01-08
公開日2022-01-26
最終更新日2022-05-04
実験手法ELECTRON MICROSCOPY (3.61 Å)
主引用文献Molecular basis of receptor binding and antibody neutralization of Omicron.
Nature, 604, 2022
8T25
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Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at downRBD conformation.
分子名称: Angiotensin-converting enzyme, Spike glycoprotein
著者Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B.
登録日2023-06-05
公開日2023-10-25
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2.
J Med Virol, 95, 2023
8HHX
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BU of 8hhx by Molmil
SARS-CoV-2 Delta Spike in complex with FP-12A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FP-12A Fab heavy chain, ...
著者Chen, X, Wu, Y.-M.
登録日2022-11-17
公開日2023-02-01
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2.
Nat Commun, 14, 2023
7TF2
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Cryo-EM structure of SARS-CoV-2 Kappa (B.1.617.1) Q484I spike protein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhu, X, Saville, J.W, Mannar, D, Srivastava, S.S, Berezuk, A.M, Demers, J.P, Zhou, S, Tuttle, K.S, Subramaniam, S.
登録日2022-01-06
公開日2022-03-30
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants.
Nat Commun, 13, 2022
7TOX
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BU of 7tox by Molmil
Delta (B.1.617.2) SARS-CoV-2 variant spike protein (S-GSAS-Delta) in the 3-RBD-down conformation; Subclassification D5 state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2022-01-24
公開日2022-02-09
最終更新日2023-04-12
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Structural diversity of the SARS-CoV-2 Omicron spike.
Mol.Cell, 82, 2022
7YR1
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SARS-CoV-2 BA.2.75 S Trimer in complex with XG2v024
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Wang, L.
登録日2022-08-08
公開日2022-10-19
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75.
Cell Host Microbe, 30, 2022
7XIW
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SARS-CoV-2 Omicron BA.2 variant spike (state 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Wang, X, Wang, L.
登録日2022-04-14
公開日2022-07-13
最終更新日2022-08-31
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection.
Nature, 608, 2022
7XMX
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Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three F61 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, F61 heavy chain, F61 light chain, ...
著者Wang, X, Li, X.
登録日2022-04-27
公開日2022-11-23
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages.
Cell Discov, 8, 2022
7KMZ
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Cryo-EM structure of double ACE2-bound SARS-CoV-2 trimer Spike at pH 7.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者Gorman, J, Kwong, P.D, Shapiro, L.
登録日2020-11-03
公開日2020-12-09
最終更新日2021-12-15
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
7EJZ
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Complex Structure of antibody BD-503 and RBD-S477N of COVID-19
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of BD-503, Light Chain of BD-503, ...
著者Xu, H, Wang, B, Zhao, T.N, Su, X.D.
登録日2021-04-03
公開日2022-04-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.63 Å)
主引用文献Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants.
Cell Res., 31, 2021
8BG8
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SARS-CoV-2 S protein in complex with pT1696 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1696 Fab heavy chain, ...
著者Hansen, G, Benecke, T, Vollmer, B, Gruenewald, K, Krey, T.
登録日2022-10-27
公開日2023-11-08
実験手法ELECTRON MICROSCOPY (3.64 Å)
主引用文献Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses?
To be published
7WKA
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SARS-CoV-2 Omicron closed state spike protein in complex with S3H3 Fab
分子名称: Heavy chain of S3H3 Fab, Light chain of S3H3 Fab, Spike glycoprotein
著者Hong, Q, Cong, Y.
登録日2022-01-08
公開日2022-01-26
最終更新日2022-05-04
実験手法ELECTRON MICROSCOPY (3.64 Å)
主引用文献Molecular basis of receptor binding and antibody neutralization of Omicron.
Nature, 604, 2022
8YRP
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SARS-CoV-2 Delta Spike in complex with JM-1A
分子名称: JM-1A Heavy Chain, JM-1A Light Chain, Spike glycoprotein
著者Nguyen, V.H.T, Chen, X.
登録日2024-03-21
公開日2024-06-05
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.64 Å)
主引用文献The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine.
Plos Pathog., 20, 2024

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件を2024-07-10に公開中

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